• Stereoselective synthesis of Z-a,b-unsaturated esters
• Stereoselective synthesis of Z-a,b-unsaturated amides
• Stereoselective synthesis of Z-a,b-unsaturated macrolactones by intramolecular HWE reaction
• Development of solvent-free HWE reaction

Theoretical studies of organic reactions

• Studies on reaction mechanisms and stereoselectivity

Synthesis of biomolecule analogues and studies on their biological activity

• Synthesis of optically active cyclopentene derivatives by a novel domino reaction
• Synthesis of nucleosides phosphorylated at their carbonyl groups
• Chemical synthesis of archaeosine
• Development of α-selective ribofuranosylation reaction
• Stereoselective synthesis of 1,2-cis-glycosyl sulfones and their application
• Asymmetric synthesis of organophosphorus compounds having a stereogenic phosphorus atom