研究業績

兵藤文紀

Mori T, Kato H, Kawaguchi M, Hatano Y, Ishihara T, Noda Y, Hyodo F, Matsuo M, Furui T, Morishige KI.
Correction: A comparative analysis of MRI findings in endometrial cancer: differentiation between endometrioid adenocarcinoma, serous carcinoma, and clear cell carcinoma.
Eur Radiol. 2025;35(4):2358.
Maeda T, Kato H, Ando T, Kawaguchi M, Shibata H, Ogawa T, Noda Y, Hyodo F, Matsuo M.
MRI features of histological subtypes of thyroid cancer in comparison with CT findings:differentiation between anaplastic, poorly differentiated, and papillary thyroid carcinoma
Jpn J Radiol. 2025;43(2):210-218.
Badr Y, Elhelaly AE, Hyodo F, Ichihashi K, Tomita H, Noda Y, Kato H, Matsuo M.
In vivo redox imaging of plasma-induced skin-inflammation in mice
npj imaging. 2024;2:25.
Eto H. Murata M. Kawano T. Tachibana Y. Elhelaly AE. Noda Y. Kato H. Matsuo M. Hyodo F.
Evaluation of the redox alteration in Duchenne muscular dystrophy model mice using in vivo DNP-MRI
npj imaging. 2024;2:52.
Noda Y, Takai Y, Suto T, Yamada N, Mori T, Kawai N, Kaga T, Hyodo F, Kato H, Matsuo M.
Effect of X-ray tube on image quality and pancreatic ductal adenocarcinoma conspicuity in pancreatic protocol dual-energy CT
Clin Radiol. 2024;79(4):e554-e559.
Kawaguchi M, Kato H, Kobayashi K, Miyazaki T, Nagano A, Noda Y, Hyodo F, Matsuo M.
Radiologic-histopathologic correlation of fatty island sign with fat necrosis in atypical lipomatous tumor and lipoma
Clin Radiol. 2024;79(6):446-452.
Kawai N, Noda Y, Nakamura F, Kaga T, Suzuki R, Miyoshi T, Mori F, Hyodo F, Kato H, Matsuo M.
Low-tube-voltage whole-body CT angiography with extremely low iodine dose: a comparison between hybrid-iterative reconstruction and deep-learning image-reconstruction algorithms.
Clin Radiol. 2024;79(6):e791-e798.
Kawaguchi M, Kato H, Furui T, Isobe M, Noda Y, Hyodo F, Miyazaki T, Matsuo M.
Prediction of grading of ovarian endometrioid carcinoma using conventional MRI features
Jpn J Radiol. 2024 Dec 28.
Aisu Y, Oshima N, Hyodo F, Elhelaly AE, Masuo A, Okada T, Hisamori S, Tsunoda S, Hida K, Morimoto T, Miyoshi H, Taketo MM, Matsuo M, Neckers LM, Sakai Y, Obama K.
Dual inhibition of oxidative phosphorylation and glycolysis exerts a synergistic antitumor effect on colorectal and gastric cancer by creating energy depletion and preventing metabolic switch.
PLoS One. 2024;19(12):e0309700.
Kawaguchi M, Kato H, Kanayama T, Tomita H, Hara A, Shibata H, Ogawa T, Hatakeyama D, Yamada Y, Ando T, Noda Y, Hyodo F, Matsuo M.
Prognostic value of radiological T category using conventional MRI in patients with oral tongue cancer: comparison with pathological T category.
Neuroradiology. 2024;66(6):907-917.
Iritani Y, Kato H, Kaneko Y, Ishihara T, Ando T, Kawaguchi M, Shibata H, Ogawa T, Noda Y, Hyodo F, Matsuo M.
FDG uptake in the cervical muscles after neck dissection: imaging features and postoperative natural course on 18F‑FDG‑PET/CT.
Jpn J Radiol. 2024;42(8):892-898.
Kawaguchi M, Kato H, Furui T, Noda Y, Hyodo F, Miyazaki T, Matsuo M.
MRI findings of malignant transformation arising from mature cystic teratoma of the ovary: comparison with benign mature cystic teratoma.
Jpn J Radiol. 2024;42(5):500-507.
Noda Y, Koyasu H, Kambadakone A, Kawai N, Naruse T, Ito A, Kaga T, Hyodo F, Kato H, Matsuo M.
Optimized versus conventional trigger threshold for pancreatic phase image acquisition using dual-energy CT at 40-keV: a randomized controlled trial.
Abdom Radiol (NY). 2024 Oct 21.
Kondo Y, Saito Y, Seki T, Takakusagi Y, Koyasu N, Saito K, Morimoto J, Nonaka H, Miyanishi K, Mizukami W, Negoro M, Elhelaly AE, Hyodo F, Matsuo M, Raju N, Swenson RE, Krishna MC, Yamamoto K, Sando S.
Directly monitoring the dynamic in vivo metabolisms of hyperpolarized 13C-oligopeptides.
Sci Adv. 2024;10(42):eadp2533.
Takai Y, Kato H, Kawaguchi M, Kobayashi K, Kikuno K, Furui T, Isobe M, Noda Y, Hyodo F, Matsuo M.
MRI characteristics of ovarian metastasis: differentiation from stomach and colorectal cancer.
Jpn J Radiol. 2024 Nov 14.
Koyasu N, Hyodo F, Iwasaki R, Elhelaly AE, Mori T, Noda Y, Kato H, Krishna MC, Kishimoto S, Matsuo M.
Quantitative spatial visualization of X-ray irradiation via redox reaction by dynamic nuclear polarization magnetic resonance imaging.
Free Radic Biol Med. 2024:225:388-397.
Kawaguchi M, Kato H, Kanayama T, Tomita H, Hara A, Shibata H, Ogawa T, Hatakeyama D, Yamada Y, Ando T, Noda Y, Hyodo F, Matsuo M.
Prognostic value of radiological T category using conventional MRI in patients with oral tongue cancer: comparison with pathological T category.
Neuroradiology. 2024;66(6):907-917.
Iritani Y, Kato H, Kaneko Y, Ishihara T, Ando T, Kawaguchi M, Shibata H, Ogawa T, Noda Y, Hyodo F, Matsuo M.
FDG uptake in the cervical muscles after neck dissection: imaging features and postoperative natural course on 18F‑FDG‑PET/CT.
Jpn J Radiol. 2024;42(8):892-898.
Kawaguchi M, Kato H, Furui T, Noda Y, Hyodo F, Miyazaki T, Matsuo M.
MRI findings of malignant transformation arising from mature cystic teratoma of the ovary: comparison with benign mature cystic teratoma.
Jpn J Radiol. 2024;42(5):500-507.
Noda Y, Ando T, Kaga T, Yamda N, Seko T, Ishihara T, Kawai N, Miyoshi T, Ito A, Naruse T, Hyodo F, Kato H, Kambadakone AR, Matsuo M.
Pancreatic cancer detection with dual-energy CT: diagnostic performance of 40 keV and 70 keV virtual monoenergetic images.
Radiol Med. 2024;129(5):677-686.
Kawaguchi M, Kato H, Koie T, Noda Y, Hyodo F, Miyazaki T, Matsuo M.
CT and MRI findings of small cell neuroendocrine carcinoma of the urinary bladder: comparison with urothelial carcinoma.
Abdom Radiol (NY). 2024;49(8):2672-2682.
Noda Y, Asano M, Kawai N, Kaga T, Kajita K, Peeters JM, Ueda Y, Honda M, Takai Y, Ito A, Hyodo F, Kato H, Matsuo M.
Appropriate pancreatic phase image acquisition by free-breathing dynamic contrast-enhanced pancreatic MRI using stack-of-stars radial sampling and Compressed SENSE.
Eur J Radiol. 2024;175:111445.
Kawai N, Kaga T, Miyoshi T, Hyodo F, Kato H, Miyazaki T, Matsuhashi N, Yoshida K, Matsuo M.
Assessment of Arterial Involvement in Pancreatic Cancer: Utility of Reconstructed CT Images Perpendicular to Artery.
Cancers (Basel). 2024;16(12):2271.
Yamada N, Kato H, Kawaguchi M, Suzui N, Miyazaki T, Nagano A, Noda Y, Hyodo F, Matsuo M.
Magnetic Resonance Imaging Features for Differentiating Low-Grade and High-Grade Malignant Peripheral Nerve Sheath Tumors.
J Comput Assist Tomogr. 2024;48(3):436-442.
Kaga T, Noda Y, Asano M, Kawai N, Kajita K, Takai Y, Ejima F, Hyodo F, Kato H, Fukukura Y, Matsuo M.
Diffusion-weighted Echo Planar Imaging with Compressed SENSE (EPICS-DWI) for Pancreas Assessment: A Multicenter Study.
Magn Reson Med Sci. 2024 Aug 6.
Seko T, Kato H, Ando T, Kobayashi K, Shibata H, Ogawa T, Kawaguchi M, Noda Y, Hyodo F, Matsuo M.
Thyroid hemiatrophy associated with papillary thyroid carcinoma.
Neuroradiology. 2024;66(10):1795-1803.
Noda Y, Takai Y, Asano M, Yamada N, Seko T, Kawai N, Kaga T, Miyoshi T, Hyodo F, Kato H, Matsuo M.
Comparison of image quality and pancreatic ductal adenocarcinoma conspicuity between the low-kVp and dual-energy CT reconstructed with deep-learning image reconstruction algorithm.
Eur J Radiol. 2023;159:110685.
Takai Y, Noda Y, Asano M, Kawai N, Kaga T, Tsuchida Y, Miyoshi T, Hyodo F, Kato H, Matsuo M.
Deep-learning image reconstruction for 80-kVp pancreatic CT protocol: Comparison of image quality and pancreatic ductal adenocarcinoma visibility with hybrid-iterative reconstruction.
Eur J Radiol. 2023;165:110960.
Kaga T, Noda Y, Nagata S, Kawai N, Miyoshi T, Hyodo F, Kato H, Matsuo M.
Comparison of image quality, arterial depiction, and radiation dose between two rapid kVp-switching dual-energy CT scanners in CT angiography at 40-keV.
Jpn J Radiol. 2023;41(11):1298-1307.
Kaga T, Noda Y, Asano M, Kawai N, Kajita K, Hyodo F, Kato H, Matsuo M.
Diagnostic ability of diffusion-weighted imaging using echo planar imaging with compressed SENSE (EPICS) for differentiating hepatic hemangioma and liver metastasis.
Eur J Radiol. 2023;167:111059.
Yamaguchi T, Matsuo M, Mori T, Noda Y, Makita C, Hyodo F, Iinuma K, Nakano M, Koie T, Tanaka H.
Seed Density as a New Predictive Index of Seed Migration in Brachytherapy for Prostate Cancer Using Iodine-125 Loose Seed.
Curr Oncol. 2023;30(4):4060-4066.
Ando T, Kato H, Shibata H, Ogawa T, Noda Y, Hyodo F, Matsuo M.
Prognostic Factors of Pretreatment Magnetic Resonance Imaging for Predicting Clinical Outcome in Patients With Parotid Gland Cancer.
J Comput Assist Tomogr. 2023;47(3):507-513.
Hayashi Y, Hyodo F, Tana, Nakagawa K, Ishihara T, Matsuo M, Shimohata T, Nishihira J, Kobori M, Nakagawa T.
Continuous intake of quercetin-rich onion powder may improve emotion but not regional cerebral blood flow in subjects with cognitive impairment.
Heliyon. 2023;9(8):e18401.
Noda Y, Mizuno N, Kawai N, Ando T, Kawaguchi M, Nagata S, Fujimoto K, Nakamura F, Kaga T, Ishihara T, Hyodo F, Kato H, Kambadakone AR, Matsuo M.
Determination of arterial invasion in pancreatic ductal adenocarcinoma: what is the best diagnostic criterion on CT?
Eur Radiol. 2023;33(5):3617-3626.
Kaga T, Kato H, Imai T, Ando T, Noda Y, Miura T, Enomoto Y, Hyodo F, Iwama T, Matsuo M.
Non-invasive regional cerebral blood flow quantification in the 123I-IMP autoradiography using artificial neural network.
PLoS One. 2023;18(3):e0281958.
Kawaguchi M, Kato H, Kobayashi K, Miyazaki T, Nagano A, Noda Y, Hyodo F, Matsuo M.
Differences in MRI findings of superficial spindle cell lipoma and atypical lipomatous tumor/well-differentiated liposarcoma.
Br J Radiol. 2023;96(1143):20220743.
Mori T, Kato H, Kawaguchi M, Kanayama T, Furui T, Noda Y, Hyodo F, Matsuo M.
MRI characteristics for predicting histological subtypes in patients with uterine cervical adenocarcinoma.
Eur J Radiol. 2023;158:110612.
Tanahashi Y, Shoda S, Kawada H, Ando T, Nagata S, Takasu M, Hyodo F, Goshima S, Mori T, Matsuo M.
Intranodal dynamic contrast-enhanced CT lymphangiography and dynamic contrast-enhanced MR lymphangiography in microminipig.
Eur Radiol. 2023;33(5):3165-3171.
Suto T, Kato H, Kawaguchi M, Kobayashi K, Ando T, Shibata H, Ogawa T, Noda Y, Hyodo F, Matsuo M.
MRI findings of sporadic/simple lymphoepithelial cyst of the parotid gland.
Neuroradiol J. 2023;36(5):541-547.
子宮頚部腺癌患者における組織学的サブタイプ予測のためのMRIの特徴
森貴之, 加藤博基, 川口真矢, 金山知弘, 古井辰郎, 野田佳史, 兵藤文紀, 兵藤文紀, 松尾政之
日本医学放射線学会秋季臨床大会抄録集 158 110612-110612 2023
Asano H, Elhelaly AE, Hyodo F, Iwasaki R, Noda Y, Kato H, Ichihashi K, Tomita H, Murata M, Mori T, Matsuo M.
Deuterium Magnetic Resonance Imaging Using Deuterated Water-Induced 2H-Tissue Labeling Allows Monitoring Cancer Treatment at Clinical Field Strength.
Clin Cancer Res. 2023;29(24):5173-5182.
Kato H, Kawaguchi M, Ando T, Shibata H, Ogawa T, Noda Y, Hyodo F, Matsuo M.
Current status of diffusion-weighted imaging in differentiating parotid tumors.
Auris Nasus Larynx. 2023;50(2):187-195.
Noda Y, Tomita H, Ishihara T, Tsuboi Y, Kawai N, Kawaguchi M, Kaga T, Hyodo F, Hara A, Kambadakone AR, Matsuo M.
Prediction of overall survival in patients with pancreatic ductal adenocarcinoma: histogram analysis of ADC value and correlation with pathological intratumoral necrosis.
BMC Med Imaging. 2022;22(1):23.
Mori T, Kato H, Kawaguchi M, Hatano Y, Ishihara T, Noda Y, Hyodo F, Matsuo M, Furui T, Morishige KI.
A comparative analysis of MRI findings in endometrial cancer: differentiation between endometrioid adenocarcinoma, serous carcinoma, and clear cell carcinoma.
Eur Radiol. 2022;32(6):4128-4136.
Noda Y, Kawai N, Nagata S, Nakamura F, Mori T, Miyoshi T, Suzuki R, Kitahara F, Kato H, Hyodo F, Matsuo M.
Deep learning image reconstruction algorithm for pancreatic protocol dual-energy computed tomography: image quality and quantification of iodine concentration.
Eur Radiol. 2022;32(1):384-394.
Kawaguchi M, Kato H, Matsuyama K, Noda Y, Hyodo F, Matsuo M.
Prognostic value of 18F-FDG PET/CT and MRI features in patients with high-risk and very-high-risk cutaneous squamous cell carcinoma.
Br J Radiol. 2022;95(1132):20211003.
Noda Y, Kawai N, Kawamura T, Kobori A, Miyase R, Iwashima K, Kaga T, Miyoshi T, Hyodo F, Kato H, Matsuo M.
Radiation and iodine dose reduced thoraco-abdomino-pelvic dual-energy CT at 40 keV reconstructed with deep learning image reconstruction.
Br J Radiol. 2022;95(1134):20211163.
Koyasu N, Hyodo F, Iwasaki R, Eto H, Elhelaly AE, Tomita H, Shoda S, Takasu M, Mori T, Murata M, Hara A, Noda Y, Kato H, Matsuo M.
Spatiotemporal imaging of redox status using in vivo dynamic nuclear polarization magnetic resonance imaging system for early monitoring of response to radiation treatment of tumor.
Free Radic Biol Med. 2022;179:170-180.
Mizuta Y, Akahoshi T, Eto H, Hyodo F, Murata M, Tokuda K, Eto M, Yamaura K.
Noninvasive Diagnosis of the Mitochondrial Function of Doxorubicin-Induced Cardiomyopathy Using In Vivo Dynamic Nuclear Polarization-Magnetic Resonance Imaging.
Antioxidants (Basel). 2022;11(8):1454.
Kaga T, Noda Y, Mori T, Kawai N, Miyoshi T, Hyodo F, Kato H, Matsuo M.
Unenhanced abdominal low-dose CT reconstructed with deep learning-based image reconstruction: image quality and anatomical structure depiction.
Jpn J Radiol. 2022;40(7):703-711.
Noda Y, Kawai N, Kaga T, Ishihara T, Hyodo F, Kato H, Kambadakone AR, Matsuo M.
Vascular involvement and resectability of pancreatic ductal adenocarcinoma on contrast-enhanced MRI: comparison with pancreatic protocol CT.
Abdom Radiol (NY). 2022;47(8):2835-2844.
Kawaguchi M, Kato H, Noda Y, Furui T, Morishige KI, Hyodo F, Matsuo M.
Uterine extension determined by MRI: a useful parameter for differentiating subserosal leiomyomas from ovarian tumors.
Abdom Radiol (NY). 2022;47(3):1142-1149.
Kawada H, Shoda S, Miyoshi T, Takasu M, Tanahashi Y, Iwasaki R, Nagata S, Kawai N, Noda Y, Goshima S, Hyodo F, Mori T, Matsuo M.
Radiological Arterial Anatomy in Mature Microminipigs as a Pre-clinical Research Model in Interventional Radiology.
Cardiovasc Intervent Radiol. 2022;45(5):705-708.
Suto T, Kato H, Kawaguchi M, Kobayashi K, Miyazaki T, Ando T, Noda Y, Hyodo F, Matsuo M, Ishihara H, Ogawa T.
MRI findings of epithelial-myoepithelial carcinoma of the parotid gland with radiologic-pathologic correlation.
Jpn J Radiol. 2022;40(6):578-585.
Kawaguchi M, Kato H, Kobayashi K, Miyazaki T, Nagano A, Noda Y, Hyodo F, Matsuo M.
MRI findings to differentiate musculoskeletal dedifferentiated liposarcoma from atypical lipomatous tumor.
Radiol Med. 2022;127(12):1383-1389.
超偏極MRIによる疾患応用研究
兵藤文紀, 子安憲一, 江藤比奈子, Elhelaly Abdelazim Elsayed, 岩崎遼太, 森崇, 村田正治, 松尾政之
放射線生物研究 56(4) 347-362 2022
超偏極MRIによるレドックス代謝に基づく非アルコール性脂肪肝炎の非侵襲評価法の開発
兵藤文紀, 松尾政之
月刊Precision Medicine 5(1) 53-56 2022
Kawai T, Matsuo M, Takakusagi Y, Saito K, Hyodo F, Devasahayam N, Matsumoto S, Kishimoto S, Yasui H, Yamamoto K, Krishna MC.
Continuous monitoring of postirradiation reoxygenation and cycling hypoxia using electron paramagnetic resonance imaging.
NMR Biomed. 2022;35(10):e4783.
Hyodo F, Eto H, Naganuma T, Koyasu N, Elhelaly AE, Noda Y, Kato H, Murata M, Akahoshi T, Hashizume M, Utsumi H, Matsuo M.
In Vivo Dynamic Nuclear Polarization Magnetic Resonance Imaging for the Evaluation of Redox-Related Diseases and Theranostics.
Antioxid Redox Signal. 2022;36(1-3):172-184.
Kawaguchi M, Kato H, Noda Y, Kobayashi K, Miyazaki T, Hyodo F, Matsuo M.
Imaging findings of malignant skin tumors: radiological-pathological correlation.
Insights Imaging. 2022;13(1):52.
Taniguchi T, Hara T, Shimozato T, Hyodo F, Ono K, Nakaya S, Noda Y, Kato H, Tanaka O, Matsuo M.
Effect of computed tomography value error on dose calculation in adaptive radiotherapy with Elekta X-ray volume imaging cone beam computed tomography.
J Appl Clin Med Phys. 2021;22(9):271-279.
Noda Y, Kawai N, Ishihara T, Tsuboi Y, Kaga T, Miyoshi T, Hyodo F, Matsuo M.
Optimized scan delay for late hepatic arterial or pancreatic parenchymal phase in dynamic contrast-enhanced computed tomography with bolus-tracking method.
Br J Radiol. 2021;94(1122):20210315.
Kaga T, Noda Y, Mori T, Kawai N, Takano H, Kajita K, Yoneyama M, Akamine Y, Kato H, Hyodo F, Matsuo M.
Diffusion-weighted imaging of the abdomen using echo planar imaging with compressed SENSE: Feasibility, image quality, and ADC value evaluation.
Eur J Radiol. 2021;142:109889.
Noda Y, Nakamura F, Yasuda N, Miyoshi T, Kawai N, Kawada H, Hyodo F, Matsuo M.
Advantages and disadvantages of single-source dual-energy whole-body CT angiography with 50% reduced iodine dose at 40 keV reconstruction.
Br J Radiol. 2021;94(1121):20201276.
Fujimoto K, Noda Y, Kawai N, Kajita K, Akamine Y, Kawada H, Hyodo F, Matsuo M.
Comparison of mono-exponential, bi-exponential, and stretched exponential diffusion-weighted MR imaging models in differentiating hepatic hemangiomas from liver metastases
Eur J Radiol. 2021;141:109806.
Kondo Y, Saito Y, Elhelaly AE, Hyodo F, Nishihara T, Itoda M, Nonaka H, Matsuo M, Sando S.
Evaluation of enzymatic and magnetic properties of γ-glutamyl-[1-13C]glycine and its deuteration toward longer retention of the hyperpolarized state.
RSC Adv. 2021;11(59):37011-37018.
Ando T, Kato H, Kawaguchi M, Nagano A, Hyodo F, Matsuo M.
MR imaging findings for differentiating nonhemophilic hemosiderotic synovitis from diffuse-type tenosynovial giant cell tumor of the knee.
Jpn J Radiol. 2021;39(1):76-83.
Eto H, Naganuma T, Nakao M, Murata M, Elhelaly AE, Noda Y, Kato H, Matsuo M, Akahoshi T, Hashizume M, Hyodo F.
Development of 20 cm sample bore size dynamic nuclear polarization (DNP)-MRI at 16 mT and redox metabolic imaging of acute hepatitis rat model.
Free Radic Biol Med. 2021;169:149-157.
Noda Y, Nakamura F, Kawai N, Suzuki R, Miyoshi T, Ishihara T, Hyodo F, Kambadakone AR, Matsuo M.
Optimized Bolus Threshold for Dual-Energy CT Angiography with Monoenergetic Images: A Randomized Clinical Trial
Radiology. 2021;300(3):615-623.
Noda Y, Iritani Y, Kawai N, Miyoshi T, Ishihara T, Hyodo F, Matsuo M.
Deep learning image reconstruction for pancreatic low-dose computed tomography: comparison with hybrid iterative reconstruction.
Abdom Radiol (NY). 2021;46(9):4238-4244.
Noda Y, Kaga T, Kawai N, Miyoshi T, Kawada H, Hyodo F, Kambadakone A, Matsuo M.
Low-dose whole-body CT using deep learning image reconstruction: image quality and lesion detection.
Br J Radiol. 2021;94(1121):20201329.
Kinoshita T, Tomita H, Okada H, Niwa A, Hyodo F, Kanayama T, Matsuo M, Imaizumi Y, Kuroda T, Hatano Y, Miyai M, Egashira Y, Enomoto Y, Nakayama N, Sugie S, Matsumoto K, Yamaguchi Y, Matsuo M, Hara H, Iwama T, Hara A.
Endothelial cell-specific reduction of heparan sulfate suppresses glioma growth in mice.
Discov Oncol. 2021;12(1):50.
Utsumi H, Masumizu T, Kobayashi R, Tahira T, Hyodo F, Shimizu T, Naganuma T, Anzai K.
Development and Preclinical Study of Free Radical Imaging Using Field-Cycling Dynamic Nuclear Polarization MRI.
Anal Chem. 2021;93(42):14138-14145.
Hyodo F, Ito S, Eto H, Elhelaly AE, Murata M, Akahoshi T, Utsumi H, Matuso M.
Free radical imaging of endogenous redox molecules using dynamic nuclear polarization magnetic resonance imaging.
Free Radic Res. 2021;55(4):343-351.
Tanahashi Y, Iwasaki R, Shoda S, Kawada H, Ando T, Takasu M, Hyodo F, Goshima S, Mori T, Matsuo M.
Dynamic contrast-enhanced computed tomography lymphangiography with intranodal injection of water-soluble iodine contrast media in microminipig: imaging protocol and feasibility.
Eur Radiol. 2020;30(11):5913-5922.
Mu Y, Li J, Kang JH, Eto H, Zai K, Kishimura A, Hyodo F, Mori T, Katayama Y.
A Lipid-Based Nanocarrier Containing Active Vitamin D3 Ameliorates NASH in Mice via Direct and Intestine-Mediated Effects on Liver Inflammation.
Biol Pharm Bull. 2020;43(9):1413-1420.
Ide M, Sonoda N, Inoue T, Kimura S, Minami Y, Makimura H, Hayashida E, Hyodo F, Yamato M, Takayanagi R, Inoguchi T.
The dipeptidyl peptidase-4 inhibitor, linagliptin, improves cognitive impairment in streptozotocin-induced diabetic mice by inhibiting oxidative stress and microglial activation.
PLoS One. 2020;15(2):e0228750.
Ando T, Kato H, Kawaguchi M, Furui T, Morishige KI, Hyodo F, Matsuo M.
MR findings for differentiating decidualized endometriomas from seromucinous borderline tumors of the ovary.
Abdom Radiol (NY). 2020;45(6):1783-1789.
Miyai M, Kanayama T, Hyodo F, Kinoshita T, Ishihara T, Okada H, Suzuki H, Takashima S, Wu Z, Hatano Y, Egashira Y, Enomoto Y, Nakayama N, Soeda A, Yano H, Hirata A, Niwa M, Sugie S, Mori T, Maekawa Y, Iwama T, Matsuo M, Hara A, Tomita H.
Glucose transporter Glut1 controls diffuse invasion phenotype with perineuronal satellitosis in diffuse glioma microenvironment.
Neurooncol Adv. 2020;3(1):vdaa150.
Hosain MZ, Hyodo F, Mori T, Takahashi K, Nagao Y, Eto H, Murata M, Akahoshi T, Matsuo M, Katayama Y.
Development of a novel molecular probe for the detection of liver mitochondrial redox metabolism.
Sci Rep. 2020;10(1):16489.
Shoda S, Hyodo F, Tachibana Y, Kiniwa M, Naganuma T, Eto H, Koyasu N, Murata M, Matsuo M.
Imaging of Hydroxyl-Radical Generation Using Dynamic Nuclear Polarization-Magnetic Resonance Imaging and a Spin-Trapping Agent.
Anal Chem. 2020;92(21):14408-14414.
Kagiya G, Sato A, Ogawa R, Hatashita M, Kato M, Kubo M, Kojima F, Kawakami F, Nishimura Y, Abe N, Hyodo F.
Real-time visualization of intratumoral necrosis using split-luciferase reconstitution by protein trans-splicing.
Mol Ther Oncolytics. 2020;20:48-58.
Kato H, Kawaguchi M, Ando T, Kaneko Y, Hyodo F, Matsuo M.
Hypointense head and neck lesions on T2-weighted images: correlation with histopathologic findings.
Neuroradiology. 2020;62(10):1207-1217.
Iwashita T, Uemura S, Shimizu M, Hyodo F, Tomita H, Iwasaki R, Takasu M, Mori T, Tanaka H, Matsuo M.
Endoscopic Ultrasound-Guided Fine-Needle Injection of Hydrogen Peroxide into the Pancreas:Feasibility and Tolerability Study Using a Survival Porcine Model.
Ultrasound Med Biol. 2019;45(2):579-585.
Hyodo F, Naganuma T, Eto H, Murata M, Utsumi H, Matsuo M.
In vivo melanoma imaging based on dynamic nuclear polarization enhancement in melanin pigment of living mice using in vivo dynamic nuclear polarization magnetic resonance imaging.
Free Radic Biol Med. 2019;134:99-105.
Kodama Y, Hyodo F, Yamato M, Yasukawa K, Minami Y, Sonoda N, Ogawa Y, Ichikawa K, Inoguchi T.
Dynamic nuclear polarization magnetic resonance imaging and the oxygen-sensitive paramagnetic agent OX63 provide a noninvasive quantitative evaluation of kidney hypoxia in diabetic mice.
Kidney Int. 2019;96(3):787-792.
Tanaka H, Kawaguchi M, Shoda S, Miyoshi T, Iwasaki R, Hyodo F, Mori T, Hara A, Tomita H, Matsuo M.
Nuclear Accumulation of β-Catenin in Cancer Stem Cell Radioresistance and Stemness in Human Colon Cancer.
Anticancer Res. 2019;39(12):6575-6583.
Cui Y, Masaki K, Zhang X, Yamasaki R, Fujii T, Ogata H, Hayashida S, Yamaguchi H, Hyodo F, Eto H, Koyama S, Iinuma K, Yonekawa T, Matsushita T, Yoshida M, Yamada K, Kawano M, Malissen M, Malissen B, Kira J.
A novel model for treatment of hypertrophic pachymeningitis.
Ann Clin Transl Neurol. 2019;6(3):431-444.
Iwashita T, Uemura S, Shimizu M, Hyodo F, Tomita H, Iwasaki R, Takasu M, Mori T, Tanaka H, Matsuo M.
Endoscopic Ultrasound-Guided Fine-Needle Injection of Hydrogen Peroxide into the Pancreas: Feasibility and Tolerability Study Using a Survival Porcine Model.
Ultrasound Med Biol. 2019;45(2):579-585.
Matsumoto KI, Hyodo F, Mitchell JB, Krishna MC.
Effect of body temperature on the pharmacokinetics of a triarylmethyl-type paramagnetic contrast agent used in EPR oximetry.
Magn Reson Med. 2018;79(2):1212-1218.
Hyodo F, Sho T, Maity B, Fujita K, Tachibana Y, Akashi S, Mano M, Hishikawa Y, Matsuo M, Ueno T.
Photoinduced in Vivo Magnetic Resonance Imaging (MRI) with Rapid CO Release from an MnCO-Protein Needle Composite.
Chemistry. 2018;24(45):11578-11583.
Kawano T, Murata M, Kang JH, Piao JS, Narahara S, Hyodo F, Hamano N, Guo J, Oguri S, Ohuchida K, Hashizume M.
Ultrasensitive MRI detection of spontaneous pancreatic tumors with nanocage-based targeted contrast agent.
Biomaterials. 2018;152:37-46.
Irie M, Hayakawa E, Fujimura Y, Honda Y, Setoyama D, Wariishi H, Hyodo F, Miura D.
Analysis of spatiotemporal metabolomic dynamics for sensitively monitoring biological alterations in cisplatin-induced acute kidney injury.
Biochem Biophys Res Commun. 2018;496(1):140-146.
Nishihara T, Kameyama Y, Nonaka H, Takakusagi Y, Hyodo F, Ichikawa K, Sando S.
A Strategy to Design Hyperpolarized 13 C Magnetic Resonance Probes Using [1-13 C]α-Amino Acid as a Scaffold Structure.
Chem Asian J. 2017;12(9):949-953.
Meenakumari V, Utsumi H, Hyodo F, Jawahar A, Milton Franklin Benial A.
Dynamic nuclear polarization studies of nitroxyl spin probes in agarose gel using Overhauser-enhanced magnetic resonance imaging.
Magn Reson Chem. 2017;55(11):1022-1028.
Eto H, Tsuji G, Chiba T, Furue M, Hyodo F.
Non-invasive evaluation of atopic dermatitis based on redox status using in vivo dynamic nuclear polarization magnetic resonance imaging.
Free Radic Biol Med. 2017;103:209-215.
子宮頚部腺癌患者における組織学的サブタイプを予測するためのMRI特性【JST・京大機械翻訳】|||
森貴之, 加藤博基, 川口真矢, 金山知弘, 古井辰郎, 野田佳史, 兵藤文紀, 兵藤文紀, 松尾政之
日本医学放射線学会秋季臨床大会抄録集 59回 S378-S379 2022
Setoguchi K, Cui L, Hachisuka N, Obchoei S, Shinkai K, Hyodo F, Kato K, Wada F, Yamamoto T, Harada-Shiba M, Obika S, Nakano K.
Antisense Oligonucleotides Targeting Y-Box Binding Protein-1 Inhibit Tumor Angiogenesis by Downregulating Bcl-xL-VEGFR2/-Tie Axes.
Mol Ther Nucleic Acids. 2017;9:170-181.
Nakata R, Hyodo F, Murata M, Eto H, Nakaji T, Kawano T, Narahara S, Yasukawa K, Akahoshi T, Tomikawa M, Hashizume M.
In vivo redox metabolic imaging of mitochondria assesses disease progression in non-alcoholic steatohepatitis.
Sci Rep. 2017;7(1):17170.
Eto H, Hyodo F, Nakano K, Utsumi H.
Selective Imaging of Malignant Ascites in a Mouse Model of Peritoneal Metastasis Using in Vivo Dynamic Nuclear Polarization-Magnetic Resonance Imaging
Anal Chem. 2016;88(4):2021-7.
Takakusagi Y, Inoue K, Naganuma T, Hyodo F, Ichikawa K.
Effect of ionic interaction between a hyperpolarized magnetic resonance chemical probe and a gadolinium contrast agent for the hyperpolarized lifetime after dissolution
J Magn Reson. 2016;270:157-160.
Kawano T, Murata M, Hyodo F, Eto H, Kosem N, Nakata R, Hamano N, Piao JS, Narahara S, Akahoshi T, Hashizume M.
Noninvasive mapping of the redox status of dimethylnitrosamine-induced hepatic fibrosis using in vivo dynamic nuclear polarization-magnetic resonance imaging.
Sci Rep. 2016;6:32604.
Ito S, Hyodo F.
Dynamic nuclear polarization-magnetic resonance imaging at low ESR irradiation frequency for ascorbyl free radicals
Sci Rep. 2016;6:21407.
Nishihara T, Yoshihara HA, Nonaka H, Takakusagi Y, Hyodo F, Ichikawa K, Can E, Bastiaansen JA, Takado Y, Comment A, Sando S.
Direct Monitoring of γ-Glutamyl Transpeptidase Activity In Vivo Using a Hyperpolarized (13) C-Labeled Molecular Probe.
Angew Chem Int Ed Engl. 2016;55(36):10626-9.
Kagiya G, Ogawa R, Hyodo F, Yamashita K, Nakamura M, Ishii A, Sejimo Y, Tominaga S, Murata M, Tanaka Y, Hatashita M.
Development of a real-time imaging system for hypoxic cell apoptosis.
Mol Ther Methods Clin Dev. 2016;5:16009.
Sonoda N, Inoguchi T, Minami Y, Hyodo F, Ichikawa K, Yamato M, Utsumi H, Takayanagi R.
[Evaluation of Brain Redox Status and Its Association with Cognitive Dysfunction in Diabetic Animal Models by Redox Molecular Imaging (ReMI)]
Yakugaku Zasshi. 2016;136(8):1081-6.
Hyodo F, Ito S, Eto H, Nakaji T, Yasukawa K, Kobayashi R, Utsumi H.
[Development of Redox Metabolic Imaging Using Endogenous Molecules]
Yakugaku Zasshi. 2016;136(8):1107-14.
Eto H, Hyodo F, Kosem N, Kobayashi R, Yasukawa K, Nakao M, Kiniwa M, Utsumi H.
Redox imaging of skeletal muscle using in vivo DNP-MRI and its application to an animal model of local inflammation
Free Radic Biol Med. 2015;89:1097-104.
Anzai K, Hyodo F.
[Imaging in vivo redox metabolism. Foreword]
Yakugaku Zasshi. 2015;135(5):717-8.
Utsumi H, Hyodo F.
Free Radical Imaging Using In Vivo Dynamic Nuclear Polarization-MRI
Methods Enzymol. 2015;564:553-71.
Hyodo F, Ito S, Utsumi H.
[Redox Molecular Imaging Using ReMI]
Yakugaku Zasshi. 2015;135(5):725-31.
Kato TA, Hyodo F, Yamato M, Utsumi H, Kanba S.
[Redox and microglia in the pathophysiology of schizophrenia]
Yakugaku Zasshi. 2015;135(5):739-43.
Hyodo F, Ito S, Yasukawa K, Kobayashi R, Utsumi H.
Simultaneous and spectroscopic redox molecular imaging of multiple free radical intermediates using dynamic nuclear polarization-magnetic resonance imaging
Anal Chem. 2014;86(15):7234-8.
Hyodo F, Davis RM, Hyodo E, Matsumoto S, Krishna MC, Mitchell JB.
The relationship between tissue oxygenation and redox status using magnetic resonance imaging
Int J Oncol. 2012;41(6):2103-8.
Kosem N, Naganuma T, Ichikawa K, Phumala Morales N, Yasukawa K, Hyodo F, Yamada K, Utsumi H.
Whole-body kinetic image of a redox probe in mice using Overhauser-enhanced MRI
Free Radic Biol Med. 2012;53(2):328-36.
Matsumoto A, Matsumoto K, Matsumoto S, Hyodo F, Sowers AL, Koscielniak JW, Devasahayam N, Subramanian S, Mitchell JB, Krishna MC.
Intracellular hypoxia of tumor tissue estimated by noninvasive electron paramagnetic resonance oximetry technique using paramagnetic probes
Biol Pharm Bull. 2011;34(1):142-5.
Matsumoto K, Hyodo F, Anzai K, Utsumi H, Mitchell JB, Krishna MC.
Brain redox imaging
Methods Mol Biol. 2011;711:397-419.
Samuni Y, Ishii H, Hyodo F, Samuni U, Krishna MC, Goldstein S, Mitchell JB.
Reactive oxygen species mediate hepatotoxicity induced by the Hsp90 inhibitor geldanamycin and its analogs
Free Radic Biol Med. 2010;48(11):1559-63.
Miura D, Fujimura Y, Yamato M, Hyodo F, Utsumi H, Tachibana H, Wariishi H.
Ultrahighly sensitive in situ metabolomic imaging for visualizing spatiotemporal metabolic behaviors
Anal Chem. 2010;82(23):9789-96.
Citrin D, Cotrim AP, Hyodo F, Baum BJ, Krishna MC, Mitchell JB.
Radioprotectors and mitigators of radiation-induced normal tissue injury
Oncologist. 2010;15(4):360-71.
Hyodo F, Chandramouli GV, Matsumoto S, Matsumoto K, Mitchell JB, Krishna MC, Munasinghe JP.
Estimation of tumor microvessel density by MRI using a blood pool contrast agent
Int J Oncol. 2009;35(4):797-804.
Hyodo F, Matsumoto S, Devasahayam N, Dharmaraj C, Subramanian S, Mitchell JB, Krishna MC.
Pulsed EPR imaging of nitroxides in mice
J Magn Reson. 2009;197(2):181-5.
Hyodo F, Murugesan R, Matsumoto K, Hyodo E, Subramanian S, Mitchell JB, Krishna MC.
Monitoring redox-sensitive paramagnetic contrast agent by EPRI, OMRI and MRI
J Magn Reson. 2008;190(1):105-12.
Yasuda S, Ikuta K, Uwatoku T, Oi K, Abe K, Hyodo F, Yoshimitsu K, Sugimura K, Utsumi H, Katayama Y, Shimokawa H.
In vivo magnetic resonance imaging of atherosclerotic lesions with a newly developed Evans blue-DTPA-gadolinium contrast medium in apolipoprotein-E-deficient mice.
J Vasc Res. 2008;45(2):123-8.
Matsumoto S, Hyodo F, Subramanian S, Devasahayam N, Munasinghe J, Hyodo E, Gadisetti C, Cook JA, Mitchell JB, Krishna MC.
Low-field paramagnetic resonance imaging of tumor oxygenation and glycolytic activity in mice
J Clin Invest. 2008;118(5):1965-73.
Hyodo F, Chuang KH, Goloshevsky AG, Sulima A, Griffiths GL, Mitchell JB, Koretsky AP, Krishna MC
Brain redox imaging using blood-brain barrier-permeable nitroxide MRI contrast agent
J Cereb Blood Flow Metab. 2008;28(6):1165-74.
Isenberg JS, Hyodo F, Ridnour LA, Shannon CS, Wink DA, Krishna MC, Roberts DD.
Thrombospondin 1 and vasoactive agents indirectly alter tumor blood flow
Neoplasia. 2008;10(8):886-96.
Isenberg JS, Maxhimer JB, Hyodo F, Pendrak ML, Ridnour LA, DeGraff WG, Tsokos M, Wink DA, Roberts DD.
Thrombospondin-1 and CD47 limit cell and tissue survival of radiation injury
Am J Pathol. 2008;173(4):1100-12.
Hyodo F, Soule BP, Matsumoto K, Matusmoto S, Cook JA, Hyodo E, Sowers AL, Krishna MC, Mitchell JB.
Assessment of tissue redox status using metabolic responsive contrast agents and magnetic resonance imaging.
J Pharm Pharmacol. 2008;60(8):1049-60.
Hama Y, Matsumoto K, Murugesan R, Subramanian S, Devasahayam N, Koscielniak JW, Hyodo F, Cook JA, Mitchell JB, Krishna MC.
Continuous wave EPR oximetric imaging at 300 MHz using radiofrequency power saturation effects
Antioxid Redox Signal. 2007;9(10):1709-16.
Devasahayam N, Subramanian S, Murugesan R, Hyodo F, Matsumoto K, Mitchell JB, Krishna MC.
Strategies for improved temporal and spectral resolution in in vivo oximetric imaging using time-domain EPR
Magn Reson Med. 2007;57(4):776-83.
Cotrim AP, Hyodo F, Matsumoto K, Sowers AL, Cook JA, Baum BJ, Krishna MC, Mitchell JB.
Differential radiation protection of salivary glands versus tumor by Tempol with accompanying tissue assessment of Tempol by magnetic resonance imaging
Clin Cancer Res. 2007;13(16):4928-33.
Matsumoto S, Yamada K, Hirata H, Yasukawa K, Hyodo F, Ichikawa K, Utsumi H.
Advantageous application of a surface coil to EPR irradiation in overhauser-enhanced MRI
Magn Reson Med. 2007;57(4):806-11.
Yasuda S, Ikuta K, Uwatoku T, Oi K, Abe K, Hyodo F, Yoshimitsu K, Sugimura K, Utsumi H, Katayama Y, Shimokawa H.
In vivo magnetic resonance imaging of atherosclerotic lesions with a newly developed Evans blue-DTPA-gadolinium contrast medium in apolipoprotein-E-deficient mice
J Vasc Res. 2008;45(2):123-8.
Isenberg JS, Hyodo F, Matsumoto K, Romeo MJ, Abu-Asab M, Tsokos M, Kuppusamy P, Wink DA, Krishna MC, Roberts DD.
Thrombospondin-1 limits ischemic tissue survival by inhibiting nitric oxide-mediated vascular smooth muscle relaxation
Blood. 2007;109(5):1945-52.
Isenberg JS, Hyodo F, Pappan LK, Abu-Asab M, Tsokos M, Krishna MC, Frazier WA, Roberts DD.
Blocking thrombospondin-1/CD47 signaling alleviates deleterious effects of aging on tissue responses to ischemia
Arterioscler Thromb Vasc Biol. 2007;27(12):2582-8.
Soule BP, Hyodo F, Matsumoto K, Simone NL, Cook JA, Krishna MC, Mitchell JB.
The chemistry and biology of nitroxide compounds
Free Radic Biol Med. 2007;42(11):1632-50.
Soule BP, Hyodo F, Matsumoto K, Simone NL, Cook JA, Krishna MC, Mitchell JB.
Therapeutic and clinical applications of nitroxide compounds
Antioxid Redox Signal. 2007;9(10):1731-43.
Hyodo F, Matsumoto K, Matsumoto A, Mitchell JB, Krishna MC.
Probing the intracellular redox status of tumors with magnetic resonance imaging and redox-sensitive contrast agents
Cancer Res. 2006;66(20):9921-8.
Matsumoto K, Hyodo F, Matsumoto A, Koretsky AP, Sowers AL, Mitchell JB, Krishna MC.
High-resolution mapping of tumor redox status by magnetic resonance imaging using nitroxides as redox-sensitive contrast agents
Clin Cancer Res. 2006;12(8):2455-62.
Hyodo F, Yasukawa K, Yamada K, Utsumi H.
Spatially resolved time-course studies of free radical reactions with an EPRI/MRI fusion technique
Magn Reson Med. 2006;56(4):938-43.
Yasukawa K, Kasazaki K, Hyodo F, Utsumi H.
Non-invasive analysis of reactive oxygen species generated in rats with water immersion restraint-induced gastric lesions using in vivo electron spin resonance spectroscopy.
Free Radic Res. 2004;38(2):147-55.
Yamamoto T, Ikuta K, Oi K, Abe K, Uwatoku T, Hyodo F, Murata M, Shigetani N, Yoshimitsu K,Shimokawa H, Utsumi H, Katayama Y.
In vivo MR detection of vascular endothelial injury using a new class of MRI contrast agent.
Bioorg Med Chem Lett. 2004;14(11):2787-90.
Suto T, Kawaguchi M, Kato H, Shibata H, Ogawa T, Ando T, Noda Y, Hyodo F, Matsuo M.
Imaging Findings of Human Papillomavirus-Positive and Human Papillomavirus-Negative Oropharyngeal Squamous Cell Carcinoma Associated with Recurrence.
J Clin Med. 2025;14(3):1027.
Kato H, Ando T, Kito Y, Shibata H, Ogawa T, Seko T, Kawaguchi M, Noda Y, Hyodo F, Matsuo M.
MRI and 18F-FDG-PET/CT findings of cervical reactive lymphadenitis: a comparison with nodal lymphoma
Pol J Radiol. 2025;90:e9-e18.
Kaga T, Kato H, Kawaguchi M, Kanayama T, Nagano A, Omata S, Noda Y, Hyodo F, Matsuo M.
MRI Characteristics for Distinguishing Solitary Fibrous Tumor From Desmoid Tumor
Korean J Radiol. 2025;26(2):169-179.
Kaga T, Kato H, Kawaguchi M, Kanayama T, Nagano A, Omata S, Noda Y, Hyodo F, Matsuo M.
MRI Characteristics for Distinguishing Solitary Fibrous Tumor From Desmoid Tumor
Korean J Radiol. 2025;26(2):169-179.
Takai Y, Kato H, Kawaguchi M, Kobayashi K, Kikuno K, Furui T, Isobe M, Noda Y, Hyodo F, Matsuo M.
MRI characteristics of ovarian metastasis: differentiation from stomach and colorectal cancer
Jpn J Radiol. 2025;43(4):676-686.

西脇理英

Matsushima-Nishiwaki R, Honda Y, Tokuda H, Kozawa O.
Gallein, G protein βγ subunits inhibitor, suppresses the TGF-α-induced migration of hepatocellular carcinoma cells via inhibition of the c-Jun N-terminal kinase.
Biochem Cell Biol. 2025:103:1-9.
Tokuda H, Hori T, Onuma T, Enomoto Y, Doi T, Matsushima-Nishiwaki R, Yamaguchi S, Tanabe K, Omura T, Ogura S, Iwama T, Iida H, Kozawa O.
Serotonin reuptake inhibitor suppresses the activation of human platelets by a combination of thrombopoietin and collagen through inhibition of Rac and Rho/Rho-kinase.
Biomed Res. 2024;45(6):231-241.
Kuroyanagi G, Hioki T, Matsushima-Nishiwaki R, Omura T, Kozawa O, Tokuda H.
Gallein increases prostaglandin F2α‑induced osteoprotegerin and IL‑6 secretion in osteoblasts.
Biomed Rep. 2024;21(5):147.
Hioki T, Kuroyanagi G, Matsushima-Nishiwaki R, Omura T, Kozawa O, Tokuda H.
Gallein but not fluorescein enhances the PGD2-stimulated synthesis of osteoprotegerin and interleukin-6 in osteoblasts: Amplification of osteoprotegerin/interleukin-6 by gallein.
Prostaglandins Leukot Essent Fatty Acids. 2024;203:102639.
Kuroyanagi G, Hioki T, Matsushima-Nishiwaki R, Kozawa O, Tokuda H.
Gallein increases the fibroblast growth factor 2-elicited osteoprotegerin synthesis in osteoblasts.
Biochim Biophys Acta Gen Subj. 2024;1868(8):130635.
Hioki T, Tachi J, Matsushima-Nishiwaki R, Iida H, Kozawa O, Tokuda H.
Oncostatin M suppresses bone morphogenetic protein-4-induced osteoprotegerin synthesis in MC3T3-E1 osteoblast-like cells: p70 S6 kinase attenuation.
Cell Biochem Funct. 2024;42(4):e4068.
Tokuda H, Hori T, Mizutani D, Hioki T, Kojima K, Onuma T, Enomoto Y, Doi T, Matsushima-Nishiwaki R, Ogura S, Iida H, Iwama T, Sakurai T, Kozawa O.
Inverse relationship between platelet Akt activity and hippocampal atrophy: A pilot case-control study in patients with diabetes mellitus.
World J Clin Cases. 2024 16;12(2):302-313.
Hioki T, Tachi J, Ueda K, Matsushima-Nishiwaki R, Iida H, Kozawa O, Tokuda H.
Oncostatin M enhances osteoprotegerin synthesis but reduces macrophage colony stimulating factor synthesis in bFGF stimulated osteoblast like cells.
Exp Ther Med. 2023 24;27(1):34.
Kuroyanagi G, Hioki T, Matsushima-Nishiwaki R, Kozawa O, Tokuda H.
HSP70 inhibitor amplifies the bFGF-induced release of IL-6 in osteoblasts.
Mol Med Rep. 2023 28 (6):230.
Matsushima-Nishiwaki R, Kamoi S, Kozawa O.
Upregulation by duloxetine of the transforming growth factor-α-induced migration of hepatocellular carcinoma cells via enhancement of the c-Jun N-terminal kinase activity.
Cell Biochem Funct. 2023, 41(7):814-822.
Kuroyanagi G, Hioki T, Tachi J, Matsushima-Nishiwaki R, Iida H, Tokuda H, Kozawa O.
Resveratrol inhibits bFGF-induced M-CSF synthesis via the PI3-kinase/Akt pathway in osteoblasts.
Biosci Biotechnol Biochem. 2023, 87(12):1462-1469.
Enomoto Y, Onuma T, Hori T, Tanabe K, Ueda K, Mizutani D, Doi T, Matsushima-Nishiwaki R, Ogura S, Iida H, Iwama T, Kozawa O, Tokuda H.
Synergy by Ristocetin and CXCL12 in Human Platelet Activation: Divergent Regulation by Rho/Rho-Kinase and Rac.
Int J Mol Sci. 2023 3;24(11):9716.
Kuroyanagi G, Hioki T, Tachi J, Matsushima-Nishiwaki R, Iida H, Kozawa O, Tokuda H.
Oncostatin M stimulates prostaglandin D2-induced osteoprotegerin and interleukin-6 synthesis in osteoblasts.
Prostaglandins Leukot Essent Fatty Acids. 2023;192:102575.
Iida H, Onuma T, Nakashima D, Mizutani D, Hori T, Ueda K, Hioki T, Kim W, Enomoto Y, Doi T, Matsushima-Nishiwaki R, Yamaguchi S, Tachi J, Tanabe K, Ogura S, Iwama T, Kozawa O, Tokuda H.
Tramadol regulates the activation of human platelets via Rac but not Rho/Rho-kinase.
PLoS One. 2023;18(1):e0279011.
Hioki T, Kuroyanagi G, Matsushima-Nishiwaki R, Kozawa O, Tokuda H.
Oncostatin M attenuates tumor necrosis factor-α-induced synthesis of macrophage-colony stimulating factor via suppression of Akt in osteoblasts.
Connect Tissue Res. 2023,64(2):139-147.
Kuroyanagi G, Tachi J, Fujita K, Kawabata T, Sakai G, Nakashima D, Kim W, Tanabe K, Matsushima-Nishiwaki R, Otsuka T, Iida H, Kozawa O, Tokuda H.
HSP70 inhibitors upregulate prostaglandin E1-induced synthesis of interleukin-6 in osteoblasts.
PLoS One. 2022;17(12):e0279134.
Hioki T, Matsushima-Nishiwaki R, Tokuda H, Kozawa O.
Selective estrogen receptor modulators, acting as agonists of estrogen receptor α in osteoblasts, reduce the TGF-β-induced synthesis of macrophage colony-stimulating factor via inhibition of JNK signaling pathway.
Biomed Res. 2022;43(6):211-221.
Matsushima-Nishiwaki R, Toyoda H, Atsuyuki M, Kaneoka Y, Kumada T, Kozawa O.
Correlation between the complex of small heat shock proteins (HSPBs) and the progression in patients with hepatocellular carcinoma.
Arch Biochem Biophys. 2022,732:109461.
Kuroyanagi G, Kawabata T, Tokuda H, Fujita K, Matsushima-Nishiwaki R, Sakai G, Tachi J, Hioki T, Kim W, Iida H, Otsuka T, Kozawa O.
Attenuation by HSP90 inhibitors of EGF-elicited migration of osteoblasts: involvement of p44/p42 MAP kinase.
Connect Tissue Res. 2022;63(4):359-369.
Doi T, Hori T, Onuma T, Mizutani D, Ueda K, Enomoto Y, Matsushima-Nishiwaki R, Tanabe K, Hioki T, Tokuda H, Iwama T, Iida H, Kozawa O, Ogura S.
Thrombopoietin and collagen in low doses cooperatively induce human platelet activation.
Acute Med Surg. 2022;9(1):e769.
Kuroyanagi G, Tokuda H, Fujita K, Kawabata T, Sakai G, Kim W, Hioki T, Tachi J, Matsushima-Nishiwaki R, Otsuka T, Iida H, Kozawa O.
Upregulation of TGF-β-induced HSP27 by HSP90 inhibitors in osteoblasts.
BMC Musculoskelet Disord. 2022;23(1):495.
Doi T, Hioki T, Tachi J, Ueda K, Matsushima-Nishiwaki R, Iida H, Ogura S, Kozawa O, Tokuda H.
Oncostatin M reduces the synthesis of macrophage-colony stimulating factor stimulated by TGF-β via suppression of p44/p42 MAP kinase and JNK in osteoblasts.
Biomed Res. 2022;43(2):41-51.
Matsushima-Nishiwaki R, Yamada N, Hattori Y, Hosokawa Y, Tachi J, Hori T, Kozawa O.
SERMs (selective estrogen receptor modulator), acting as estrogen receptor β agonists in hepatocellular carcinoma cells, inhibit the transforming growth factor-α-induced migration via specific inhibition of AKT signaling pathway.
PLoS One. 2022;17(1):e0262485.
Hioki T, Kuroyanagi G, Fujita K, Sakai G, Kawabata T, Kim W, Tachi J, Matsushima-Nishiwaki R, Iida H, Kozawa O, Tokuda H.
Incretins Enhance PGF2α-Induced Synthesis of IL-6 and Osteoprotegerin in Osteoblasts.
Horm Metab Res. 2022;54(1):42-49.
Mizutani D, Tokuda H, Onuma T, Uematsu K, Nakashima D, Ueda K, Doi T, Enomoto Y, Matsushima-Nishiwaki R, Ogura S, Iida H, Kozawa O, Iwama T.
Amyloid β protein negatively regulates human platelet activation induced by thrombin receptor-activating protein.
Biosci Biotechnol Biochem. 2022,86(2):185-198.
Kuroyanagi G, Kawabata T, Tokuda H, Fujita K, Matsushima-Nishiwaki R, Sakai G, Tachi J, Hioki T, Kim W, Iida H, Otsuka T, Kozawa O.
Attenuation by HSP90 inhibitors of EGF-elicited migration of osteoblasts: involvement of p44/p42 MAP kinase.
Connect Tissue Res. 2022,63(4):359-369.
Tachi J, Onuma T, Yamaguchi S, Kim W, Hioki T, Matsushima-Nishiwaki R, Tanabe K, Tokuda H, Kozawa O, Iida H.
Duloxetine suppresses BMP-4-induced release of osteoprotegerin via inhibition of the SMAD signaling pathway in osteoblasts.
Biochem Cell Biol. 2021;99(5):578-586.
Hioki T, Tokuda H, Tanabe K, Kim W, Tachi J, Yamaguchi S, Matsushima-Nishiwaki R, Kozawa O, Iida H.
Amplification by tramadol of PGD2-induced osteoprotegerin synthesis in osteoblasts: Involvement of μ-opioid receptor and 5-HT transporter.
Prostaglandins Leukot Essent Fatty Acids. 2021;172:102323.
Hioki T, Tokuda H, Kuroyanagi G, Kim W, Tachi J, Matsushima-Nishiwaki R, Iida H, Kozawa O.
Olive polyphenols attenuate TNF-α-stimulated M-CSF and IL-6 synthesis in osteoblasts: Suppression of Akt and p44/p42 MAP kinase signaling pathways.
Biomed Pharmacother. 2021;141:111816.
Kim W, Tokuda H, Tanabe K, Yamaguchi S, Hioki T, Tachi J, Matsushima-Nishiwaki R, Kozawa O, Iida H.
Acetaminophen reduces osteoprotegerin synthesis stimulated by PGE2 and PGF2α in osteoblasts: attenuation of SAPK/JNK but not p38 MAPK or p44/p42 MAPK.
Biomed Res. 2021;42(2):77-84.
Yamada N, Matsushima-Nishiwaki R, Kobayashi K, Tachi J, Kozawa O.
GLP-1 reduces the migration of hepatocellular carcinoma cells via suppression of the stress-activated protein kinase/c-Jun N-terminal kinase pathway.
Arch Biochem Biophys. 2021;703:108851.
Tachi J, Onuma T, Yamaguchi S, Kim W, Hioki T, Matsushima-Nishiwaki R, Tanabe K, Tokuda H, Kozawa O, Iida H.
Duloxetine suppresses BMP-4-induced release of osteoprotegerin via inhibition of the SMAD signaling pathway in osteoblasts.
Biochem Cell Biol. 2021;99(5):578-586.
Kuroyanagi G, Sakai G, Otsuka T, Yamamoto N, Fujita K, Kawabata T, Matsushima-Nishiwaki R, Kozawa O, Tokuda H.
HSP22 (HSPB8) positively regulates PGF2α-induced synthesis of interleukin-6 and vascular endothelial growth factor in osteoblasts.
J Orthop Surg Res. 2021;16(1):72.
Hioki T, Tokuda H, Nakashima D, Fujita K, Kawabata T, Sakai G, Kim W, Tachi J, Tanabe K, Matsushima-Nishiwaki R, Otsuka T, Iida H, Kozawa O.
HSP90 inhibitors strengthen extracellular ATP-stimulated synthesis of interleukin-6 in osteoblasts: Amplification of p38 MAP kinase.
Cell Biochem Funct. 2021,39(1):88-97.
Nakashima D, Onuma T, Tanabe K, Kito Y, Uematsu K, Mizutani D, Enomoto Y, Tsujimoto M, Doi T, Matsushima-Nishiwaki R, Tokuda H, Ogura S, Iwama T, Kozawa O, Iida H.
Synergistic effect of collagen and CXCL12 in the low doses on human platelet activation.
PLoS One. 2020;15(10):e0241139.
Kobayashi K, Matsushima-Nishiwaki R, Yamada N, Migita S, Hioki T, Mizutani D, Kozawa O.
Heat shock protein 70 positively regulates transforming growth factor-α-induced hepatocellular carcinoma cell migration via the AKT signaling pathway.
Heliyon. 2020;6(9):e05002.
Tachi J, Tokuda H, Onuma T, Yamaguchi S, Kim W, Hioki T, Matsushima-Nishiwaki R, Tanabe K, Kozawa O, Iida H.
Duloxetine strengthens osteoblast activation by prostaglandin E1: Upregulation of p38 MAP kinase.
Prostaglandins Other Lipid Mediat. 2020;151:106481.
Hioki T, Kawabata T, Sakai G, Fujita K, Kuroyanagi G, Matsushima-Nishiwaki R, Kim W, Otsuka T, Iida H, Tokuda H, Kozawa O.
Resveratrol suppresses insulin-like growth factor I-induced osteoblast migration: attenuation of the p44/p42 MAP kinase pathway.
Biosci Biotechnol Biochem. 2020,84(12):2428-2439.
Kim W, Tanabe K, Kuroyanagi G, Matsushima-Nishiwaki R, Fujita K, Kawabata T, Sakai G, Tachi J, Hioki T, Nakashima D, Yamaguchi S, Otsuka T, Tokuda H, Kozawa O, Iida H.
Tramadol enhances PGF2α-stimulated osteoprotegerin synthesis in osteoblasts.
Heliyon. 2020;6(8):e04779.
Kawabata T, Tokuda H, Kuroyanagi G, Fujita K, Sakai G, Kim W, Matsushima-Nishiwaki R, Iida H, Yata KI, Wang S, Mizoguchi A, Otsuka T, Kozawa O.
Incretin accelerates platelet-derived growth factor-BB-induced osteoblast migration via protein kinase A: The upregulation of p38 MAP kinase.
Sci Rep. 2020;10(1):2341.
Yamada N, Matsushima-Nishiwaki R, Kozawa O.
Quercetin suppresses the migration of hepatocellular carcinoma cells stimulated by hepatocyte growth factor or transforming growth factor-α: Attenuation of AKT signaling pathway.
Arch Biochem Biophys. 2020;682:108296.
Mizutani D, Onuma T, Tanabe K, Kojima A, Uematsu K, Nakashima D, Doi T, Enomoto Y, Matsushima-Nishiwaki R, Tokuda H, Ogura S, Iida H, Kozawa O, Iwama T.
Olive polyphenol reduces the collagen-elicited release of phosphorylated HSP27 from human platelets.
Biosci Biotechnol Biochem. 2020;84(3):536-543.
Fujita K, Otsuka T, Kawabata T, Sakai G, Kim W, Matsushima-Nishiwaki R, Kozawa O, Tokuda H.
Wnt3a downregulates thyroid hormone-induced osteocalcin expression in osteoblasts.
Exp Ther Med. 2019;18(3):1921-1927.
Kawabata T, Tokuda H, Fujita K, Matsushima-Nishiwaki R, Sakai G, Tachi J, Hioki T, Kim W, Iida H, Otsuka T, Kozawa O.
HSP90 inhibitors diminish PDGF-BB-induced migration of osteoblasts via suppression of p44/p42 MAP kinase.
Biomed Res. 2019;40(4):169-178.
Yamada N, Matsushima-Nishiwaki R, Masue A, Taguchi K, Kozawa O.
Olive oil polyphenols suppress the TGF-α-induced migration of hepatocellular carcinoma cells.
Biomed Rep. 2019;1(1):1-5.
Kim W, Tokuda H, Kawabata T, Fujita K, Sakai G, Nakashima D, Tachi J, Kuroyanagi G, Matsushima-Nishiwaki R, Tanabe K, Otsuka T, Iida H, Kozawa O.
Enhancement by HSP90 inhibitor of PGD2-stimulated HSP27 induction in osteoblasts: Suppression of SAPK/JNK and p38 MAP kinase.
Prostaglandins Other Lipid Mediat. 2019;143:106327.
Matsushima-Nishiwaki R, Yamada N, Fukuchi K, Kozawa O.
Sphingosine 1-phosphate (S1P) reduces hepatocyte growth factor-induced migration of hepatocellular carcinoma cells via S1P receptor 2.
PLoS One. 2018;13(12):e0209050.
Kawabata T, Otsuka T, Fujita K, Sakai G, Kim W, Matsushima-Nishiwaki R, Kuroyanagi G, Kozawa O, Tokuda H.
HSP70 Inhibitors Reduce The Osteoblast Migration By Epidermal Growth Factor.
Curr Mol Med. 2018;18(7):486-495.
Kawabata T, Tokuda H, Sakai G, Fujita K, Matsushima-Nishiwaki R, Kuroyanagi G, Otsuka T, Kozawa O.
HSP70 Inhibitor Suppresses IGF-I-Stimulated Migration of Osteoblasts through p44/p42 MAP Kinase.
Biomedicines. 2018;6(4):109.
Kawabata T, Otsuka T, Fujita K, Sakai G, Matsushima-Nishiwaki R, Kozawa O, Tokuda H.
(-)-Epigallocatechin gallate but not chlorogenic acid suppresses EGF-stimulated migration of osteoblasts via attenuation of p38 MAPK activity.
Int J Mol Med. 2018;42(6):3149-3156.
Kawabata T, Tokuda H, Sakai G, Fujita K, Matsushima-Nishiwaki R, Otsuka T, Kozawa O.
Repression of IGF-I-induced osteoblast migration by (-)-epigallocatechin gallate through p44/p42 MAP kinase signaling.
Biomed Rep. 2018;9(4):318-326.
Uematsu K, Enomoto Y, Onuma T, Tsujimoto M, Doi T, Matsushima-Nishiwaki R, Tokuda H, Ogura S, Iida H, Kozawa O, Iwama T.
Rac Regulates the TRAP-Induced Release of Phosphorylated-HSP27 from Human Platelets via p38 MAP Kinase but Not JNK.
Cell Physiol Biochem. 2018;49(4):1523-1538.
Fujita K, Otsuka T, Kawabata T, Kainuma S, Sakai G, Matsushima-Nishiwaki R, Kozawa O, Tokuda H.
HSP90 limits thrombin stimulated IL 6 synthesis in osteoblast like MC3T3 E1 cells: Regulation of p38 MAPK.
Int J Mol Med. 2018;42(4):2185-2192.
Fujita K, Otsuka T, Kawabata T, Sakai G, Matsushima-Nishiwaki R, Kozawa O, Tokuda H.
Inhibitors of heat shock protein 90 augment endothelin 1 induced heat shock protein 27 through the SAPK/JNK signaling pathway in osteoblasts.
Mol Med Rep. 2018;17(6):8542-8547.
Sakai G, Tokuda H, Yamamoto N, Matsushima-Nishiwaki R, Fujita K, Kawabata T, Kozawa O, Otsuka T.
Association of HSP22 with mTOR in osteoblasts: regulation of TNF-α-stimulated IL-6 synthesis.
FEBS Lett. 2018;592(7):1202-1210.
Sakai G, Tokuda H, Fujita K, Kainuma S, Kawabata T, Matsushima-Nishiwaki R, Kozawa O, Otsuka T.
Heat Shock Protein 70 Negatively Regulates TGF-β-Stimulated VEGF Synthesis via p38 MAP Kinase in Osteoblasts.
Cell Physiol Biochem. 2017;44(3):1133-1145.
Kawabata T, Otsuka T, Fujita K, Kainuma S, Yamamoto N, Kuroyanagi G, Sakai G, Matsushima-Nishiwaki R, Kozawa O, Tokuda H.
Suppression by HSP90 inhibitors of BMP 4 stimulated osteoprotegerin synthesis in osteoblasts: Attenuation of p70 S6 kinase.
Mol Med Rep. 2017;16(6):8507-8512.
Kawabata T, Tokuda H, Fujita K, Kainuma S, Sakai G, Matsushima-Nishiwaki R, Kozawa O, Otsuka T.
Resveratrol Inhibits the Epidermal Growth Factor-Induced Migration of Osteoblasts: the Suppression of SAPK/JNK and Akt.
Cell Physiol Biochem. 2017;43(3):1025-1036.
Kainuma S, Tokuda H, Yamamoto N, Kuroyanagi G, Fujita K, Kawabata T, Sakai G, Matsushima-Nishiwaki R, Kozawa O, Otsuka T.
Heat shock protein 27 (HSPB1) suppresses the PDGF-BB-induced migration of osteoblasts.
Int J Mol Med. 2017;40(4):1057-1066.
Sakai G, Otsuka T, Fujita K, Kainuma S, Kuroyanagi G, Kawabata T, Matsushima-Nishiwaki R, Kozawa O, Tokuda H.
Amplification by (-)-epigallocatechin gallate of prostaglandin F2α stimulated synthesis of osteoprotegerin in osteoblasts.
Mol Med Rep. 2017;16(5):6376-6381.
Fujita K, Tokuda H, Kainuma S, Kuroyanagi G, Yamamoto N, Matsushima-Nishiwaki R, Harada A, Kozawa O, Otsuka T.
Resveratrol suppresses thyroid hormone induced osteocalcin synthesis in osteoblasts.
Mol Med Rep. 2017;16(3):2881-2886.
Fujita K, Otsuka T, Yamamoto N, Kainuma S, Ohguchi R, Kawabata T, Sakai G, Kuroyanagi G, Matsushima-Nishiwaki R, Kozawa O, Tokuda H.
(-)-Epigallocatechin gallate but not chlorogenic acid upregulates osteoprotegerin synthesis through regulation of bone morphogenetic protein-4 in osteoblasts.
Exp Ther Med. 2017;14(1):417-423.
Onuma T, Tanabe K, Kito Y, Tsujimoto M, Uematsu K, Enomoto Y, Matsushima-Nishiwaki R, Doi T, Nagase K, Akamatsu S, Tokuda H, Ogura S, Iwama T, Kozawa O, Iida H.
Sphingosine 1-phosphate (S1P) suppresses the collagen-induced activation of human platelets via S1P4 receptor.
Thromb Res. 2017;156:91-100.
Fujita K, Tokuda H, Kuroyanagi G, Yamamoto N, Kainuma S, Kawabata T, Sakai G, Matsushima-Nishiwaki R, Kozawa O, Otsuka T.
HSP90 inhibitors potentiate PGF2α-induced IL-6 synthesis via p38 MAP kinase in osteoblasts.
PLoS One 2017;12(5):e0177878.
Matsushima-Nishiwaki R, Toyoda H, Takamatsu R, Yasuda E, Okuda S, Maeda A, Kaneoka Y, Yoshimi N, Kumada T, Kozawa O.
Heat shock protein 22 (HSPB8) reduces the migration of hepatocellular carcinoma cells through the suppression of the phosphoinositide 3-kinase (PI3K)/AKT pathway.
Biochim Biophys Acta –Mol Basis dis. 2017;1863(6):1629-1639.
Kuroyanagi G, Tokuda H, Yamamoto N, Kainuma S, Fujita K, Ohguchi R, Matsushima-Nishiwaki R, Kozawa O, Otsuka T.
Attenuation of prostaglandin E1 induced osteoprotegerin synthesis in osteoblasts by normoxic HIF inducers.
Mol Med Rep. 2017;15(4):1847-1852.
Fujita K, Tokuda H, Yamamoto N, Kainuma S, Kawabata T, Sakai G, Kuroyanagi G, Matsushima-Nishiwaki R, Harada A, Kozawa O, Otsuka T.
Incretins amplify TNF-α-stimulated IL-6 synthesis in osteoblasts: Suppression of the IκB/NF-κB pathway.
Int J Mol Med. 2017;39(4):1053-1060.
Kuroyanagi G, Tokuda H, Yamamoto N, Kainuma S, Fujita K, Ohguchi R, Kawabata T, Sakai G, Matsushima-Nishiwaki R, Harada A, Kozawa O, Otsuka T.
(-)-Epigallocatechin gallate synergistically potentiates prostaglandin E2-stimulated osteoprotegerin synthesis in osteoblasts.
Prostaglandins Other Lipid Mediat. 2017;128-129:27-33.
Kainuma S, Tokuda H, Fujita K, Kawabata T, Sakai G, Matsushima-Nishiwaki R, Harada A, Kozawa O, Otsuka T.
Attenuation by incretins of thyroid hormone-stimulated osteocalcin synthesis in osteoblasts.
Biomed Rep. 2016;5(6):771-775.
Tsujimoto M, Tokuda H, Kuroyanagi G, Yamamoto N, Kainuma S, Matsushima-Nishiwaki R, Onuma T, Iida Y, Kojima A, Sawada S, Doi T, Enomoto Y, Tanabe K, Akamatsu S, Iida H, Ogura S, Otsuka T, Kozawa O, Iwama T.
AICAR reduces the collagen-stimulated secretion of PDGF-AB and release of soluble CD40 ligand from human platelets: Suppression of HSP27 phosphorylation via p44/p42 MAP kinase.
Exp Ther Med. 2016;12(2):1107-1112.
Yamamoto N, Tokuda H, Kuroyanagi G, Kainuma S, Matsushima-Nishiwaki R, Fujita K, Kozawa O, Otsuka T.
Heat shock protein 22 (HSPB8) limits TGF-β-stimulated migration of osteoblasts.
Mol Cell Endocrinol 2016;436:1-9.
Tokuda H, Kuroyanagi G, Tsujimoto M, Matsushima-Nishiwaki R, Akamatsu S, Enomoto Y, Iida H, Otsuka T, Ogura S, Iwama T, Kojima K, Kozawa O.
Thrombin Receptor-Activating Protein (TRAP)-Activated Akt Is Involved in the Release of Phosphorylated-HSP27 (HSPB1) from Platelets in DM Patients.
Int J Mol Sci. 2016;17(5):737.
Kainuma S, Otsuka T, Kuroyanagi G, Yamamoto N, Matsushima-Nishiwaki R, Kozawa O, Tokuda H.
Possible involvement of AMP-activated protein kinase in PGE1-induced synthesis of osteoprotegerin in osteoblasts.
Exp Ther Med. 2016;11(5):2042-2048.
Matsushima-Nishiwaki R, Toyoda H, Nagasawa T, Yasuda E, Chiba N, Okuda S, Maeda A, Kaneoka Y, Kumada T, Kozawa O.
Phosphorylated Heat Shock Protein 20 (HSPB6) Regulates Transforming Growth Factor-α-Induced Migration and Invasion of Hepatocellular Carcinoma Cells.
PLoS One 2016;11(4):e0151907.
Kainuma S, Otsuka T, Kuroyanagi G, Yamamoto N, Matsushima-Nishiwaki R, Kozawa O, Tokuda H.
Regulation by AMP-activated protein kinase of PGE2-induced osteoprotegerin synthesis in osteoblasts.
Mol Med Rep. 2016;13(4):3363-9.
Tsujimoto M, Kuroyanagi G, Matsushima-Nishiwaki R, Kito Y, Enomoto Y, Iida H, Ogura S, Otsuka T, Tokuda H, Kozawa O, Iwama T.
Factor Xa Inhibitor Suppresses the Release of Phosphorylated HSP27 from Collagen-Stimulated Human Platelets: Inhibition of HSP27 Phosphorylation via p44/p42 MAP Kinase.
PLoS One 2016;11(2):e0149077.
Kuroyanagi G, Otsuka T, Yamamoto N, Kainuma S, Ohguchi R, Fujita K, Matsushima-Nishiwaki R, Kozawa O, Tokuda H.
Mimosine suppresses the PGF2α-induced synthesis of osteoprotegerin but not interleukin-6 in osteoblasts.
Int J Mol Med. 2016;37(2):533-41.
Yamamoto N, Tokuda H, Kuroyanagi G, Kainuma S, Ohguchi R, Fujita K, Matsushima-Nishiwaki R, Kozawa O, Otsuka T.
Amplification by (-)-epigallocatechin gallate and chlorogenic acid of TNF-α-stimulated interleukin-6 synthesis in osteoblasts.
Int J Mol Med. 2015;36(6):1707-12.
Kainuma S, Tokuda H, Kuroyanagi G, Yamamoto N, Ohguchi R, Fujita K, Matsushima-Nishiwaki R, Kozawa O, Otsuka T.
PGD2 stimulates osteoprotegerin synthesis via AMP-activated protein kinase in:osteoblasts Regulation of ERK and SAPK/JNK.
Prostaglandins Leukot Essent Fatty Acids. 2015;101:23-9.
Kuroyanagi G, Tokuda H, Yamamoto N, Matsushima-Nishiwaki R, Kozawa O, Otsuka T.
Unphosphorylated HSP27 (HSPB1) regulates the translation initiation process via a direct association with eIF4E in osteoblasts.
Int J Mol Med. 2015;36(3):881-9.
Kuroyanagi G, Otsuka T, Yamamoto N, Matsushima-Nishiwaki R, Kozawa O, Tokuda H.
Resveratrol suppresses TGF-β-induced VEGF synthesis in osteoblasts: Inhibition of the p44/p42 MAPKs and SAPK/JNK pathways.
Exp Ther Med. 2015;9(6):2303-2310.
Tokuda H, Kuroyanagi G, Tsujimoto M, Enomoto Y, Matsushima-Nishiwaki R, Onuma T, Kojima A, Doi T, Tanabe K, Akamatsu S, Iida H, Ogura S, Otsuka T, Iwama T, Tanikawa T, Ishikawa K, Kojima K, Kozawa O.
Release of Phosphorylated HSP27 (HSPB1) from Platelets Is Accompanied with the Acceleration of Aggregation in Diabetic Patients.
PLoS One 2015;10(6):e0128977.
Kuroyanagi G, Tokuda H, Yamamoto N, Matsushima-Nishiwaki R, Mizutani J, Kozawa O, Otsuka T.
Resveratrol amplifies BMP-4-stimulated osteoprotegerin synthesis via p38 MAP kinase in osteoblasts.
Mol Med Rep. 2015;12(3):3849-3854.
Tsujimoto M, Doi T, Kuroyanagi G, Yamamoto N, Matsushima-Nishiwaki R, Iida Y, Enomoto Y, Iida H, Ogura S, Otsuka T, Tokuda H, Kozawa O, Iwama T.
αB-crystallin reduces ristocetin induced soluble CD40 ligand release in human platelets: Suppression of thromboxane A2 generation.
Mol Med Rep. 2015;12(1):357-62.
Suzuki M, Matsushima-Nishiwaki R, Kuroyanagi G, Suzuki N, Takamatsu R, Furui T, Yoshimi N, Kozawa O, Morishige K.
Regulation by heat shock protein 22 (HSPB8) of transforming growth factor-α-induced ovary cancer cell migration.
Arch Biochem Biophys. 2015:571:40-9.
Yamamoto N, Otsuka T, Kuroyanagi G, Kondo A, Kainuma S, Nakakami A, Matsushima-Nishiwaki R, Kozawa O, Tokuda H.
Resveratrol reduces prostaglandin E1-stimulated osteoprotegerin synthesis in osteoblasts: Suppression of stress-activated protein kinase/c-Jun N-terminal kinase.
Prostaglandins Other Lipid Mediat. 2015;116-117:57-63.
Yamamoto N, Otsuka T, Kondo A, Matsushima-Nishiwaki R, Kuroyanagi G, Kozawa O, Tokuda H.
Rac limits TGF-β-induced VEGF synthesis in osteoblasts.
Mol Cell Endocrinol. 2015;405:35-41.
Iida Y, Doi T, Tokuda H, Matsushima-Nishiwaki R, Tsujimoto M, Kuroyanagi G, Yamamoto N, Enomoto Y, Tanabe K, Otsuka T, Iwama T, Ogura S, Kozawa O, Iida H.
Rho-kinase regulates human platelet activation induced by thromboxane A2 independently of p38 MAP kinase.
Prostaglandins Leukot Essent Fatty Acids. 2015;94:73-81.
Nagasawa T, Matsushima-Nishiwaki R, Yasuda E, Matsuura J, Toyoda H, Kaneoka Y, Kumada T, Kozawa O.
Heat shock protein 20 (HSPB6) regulates TNF-α-induced intracellular signaling pathway in human hepatocellular carcinoma cells.
Arch Biochem Biophys. 2015;565:1-8.
Kuroyanagi G, Otsuka T, Yamamoto N, Matsushima-Nishiwaki R, Nakakami A, Mizutani J, Kozawa O, Tokuda H.
Down-regulation by resveratrol of basic fibroblast growth factor-stimulated osteoprotegerin synthesis through suppression of Akt in osteoblasts.
Int J Mol Sci. 2014;15(10):17886-900.
Yamamoto N, Tokuda H, Kuroyanagi G, Mizutani J, Matsushima-Nishiwaki R, Kondo A, Kozawa O, Otsuka T.
Regulation by resveratrol of prostaglandin E2-stimulated osteoprotegerin synthesis in osteoblasts.
Int J Mol Med. 2014;34(5):1439-45.
Tanabe K, Matsushima-Nishiwaki R, Kozawa O, Iida H.
Dexmedetomidine suppresses interleukin-1β-induced interleukin-6 synthesis in rat glial cells.
Int J Mol Med. 2014;34(4):1032-8.
Iida Y, Doi T, Matsushima-Nishiwaki R, Tokuda H, Ogura S, Kozawa O, Iida H.
(-)-Epigallocatechin gallate selectively inhibits adenosine diphosphate stimulated human platelet activation: suppression of heat shock protein 27 phosphorylation via p38 mitogen activated protein kinase.
Mol Med Rep. 2014;10(3):1383-8.
Nagasawa T, Matsushima-Nishiwaki R, Toyoda H, Matsuura J, Kumada T, Kozawa O.
Heat shock protein 20 (HSPB6) regulates apoptosis in human hepatocellular carcinoma cells: Direct association with Bax.
Oncol Rep. 2014;32(3):1291-5.
Kuroyanagi G, Mizutani J, Kondo A, Yamamoto N, Matsushima-Nishiwaki R, Otsuka T, Kozawa O, Tokuda H.
Suppression by resveratrol of prostaglandin D2-stimulated osteoprotegerin synthesis in osteoblasts.
Prostaglandins Leukot Essent Fatty Acids. 2014;91(3):73-80.
Kageyama Y, Doi T, Matsushima-Nishiwaki R, Iida Y, Akamatsu S, Kondo A, Kuroyanagi G, Yamamoto N, Mizutani J, Otsuka T, Tokuda H, Iida H, Kozawa O, Ogura S.
Involvement of Rac in thromboxane A2 induced human platelet activation: regulation of sCD40 ligand release and PDGF AB secretion.
Mol Med Rep. 2014;10(1):107-12.
Kondo A, Tokuda H, Matsushima-Nishiwaki R, Kuroyanagi G, Yamamoto N, Mizutani J, Kozawa O, Otsuka T.
Rho-kinase limits BMP-4-stimulated osteocalcin synthesis in osteoblasts: regulation of the p38 MAP kinase pathway.
Life Sci 2014;96(1-2):18-25.
Kondoh Y, Goda K, Matsushima-Nishiwaki R, Ogawa A, Horiuchi T, Tsuchiya T.
Time-Dissolution Profiling of the Ingredients in the Decoction of Kampo Medicines:A Case of Glycyrrhizic Acid and Phenolic Components from Kanzo-to
薬局薬学　Vol. 5 No. 1 2013, 22-29
Kondo A, Otsuka T, Kuroyanagi G, Yamamoto N, Matsushima-Nishiwaki R, Mizutani J, Kozawa O, Tokuda H.
Resveratrol inhibits BMP-4-stimulated VEGF synthesis in osteoblasts: Suppression of S6 kinase.
Int J Mol Med. 2014;33(4):1013-8.
Kuroyanagi G, Tokuda H, Matsushima-Nishiwaki R, Kondo A, Mizutani J, Kozawa O, Otsuka T.
Resveratrol suppresses prostaglandin F2α-induced osteoprotegerin synthesis in osteoblasts: Inhibition of the MAP kinase signaling.
Arch Biochem Biophys. 2014;542:39-45.
Matsushima-Nishiwaki R, Kumada T, Nagasawa T, Suzuki M, Yasuda E, Okuda S, Maeda A, Kaneoka Y, Toyoda H, Kozawa O.
Direct Association of Heat Shock Protein 20 (HSPB6) with Phosphoinositide 3-kinase (PI3K) in Human Hepatocellular Carcinoma: Regulation of the PI3K Activity.
PLoS One 2013;8(11):e78440.
Kuroyanagi G, Otsuka T, Kondo A, Matsushima-Nishiwaki R, Mizutani J, Kozawa O, Tokuda H.
(-)-Epigallocatechin gallate amplifies interleukin-1-stimulated interleukin-6 synthesis in osteoblast-like MC3T3-E1 cells.
Biochimie 2013;95(10):1933-8.
Kondo A, Tokuda H, Matsushima-Nishiwaki R, Kato K, Kuroyanagi G, Mizutani J, Fukuoka M, Wada I, Kozawa O, Otsuka T.
Unphosphorylated heat shock protein 27 suppresses fibroblast growth factor-2-stimulated vascular endothelial growth factor release in osteoblasts.
Mol Med Rep. 2013;8(2):691-5.
Kondo A, Otsuka T, Matsushima-Nishiwaki R, Kuroyanagi G, Mizutani J, Wada I, Kozawa O, Tokuda H.
Inhibition of SAPK/JNK leads to enhanced IL-1-induced IL-6 synthesis in osteoblasts.
Arch Biochem Biophys. 2013;535(2):227-33.
Kondo A, Otsuka T, Kato K, Matsushima-Nishiwaki R, Kuroyanagi G, Mizutani J, Tokuda H, Kozawa O.
AMP-activated protein kinase regulates thyroid hormone-stimulated osteocalcin synthesis in osteoblasts.
Int J Mol Med. 2013;31(6):1457-62.
Cuong NT, Doi T, Matsushima-Nishiwaki R, Akamatsu S, Kuroyanagi G, Kondo A, Mizutani J, Wada I, Otsuka T, Tokuda H, Kozawa O, Ogura S.
Thrombopoietin amplifies ADP-induced HSP27 phosphorylation in human platelets: importance of pre-treatment.
Int J Mol Med. 2013;31(6):1291-7.
Osawa Y, Suetsugu A, Matsushima-Nishiwaki R, Yasuda I, Saibara T, Moriwaki H, Seishima M, Kozawa O.
Liver acid sphingomyelinase inhibits growth of metastatic colon cancer.
J Clin Invest. 2013;123(2):834-43.
Iida M, Tanabe K, Matsushima-Nishiwaki R, Kozawa O, Iida H.
Adenosine monophosphate-activated protein kinase regulates platelet-derived growth factor-BB-induced vascular smooth muscle cell migration.
Arch Biochem Biophys. 2013;530(2):83-92.
Kondo A, Tokuda H, Kato K, Matsushima-Nishiwaki R, Kuroyanagi G, Mizutani J, Kozawa O, Otsuka T.
Rho-kinase negatively regulates thyroid hormone-stimulated osteocalcin synthesis in osteoblasts.
Biochimie 2013;95(4):719-24.
Kondo A, Otsuka T, Kato K, Natsume H, Kuroyanagi G, Mizutani J, Ito Y, Matsushima-Nishiwaki R, Kozawa O, Tokuda H.
AMP-activated protein kinase inhibitor decreases prostaglandin F2α-stimulated interleukin-6 synthesis through p38 MAP kinase in osteoblasts.
Int J Mol Med. 2012;30(6):1487-92.
Tokuda H, Kato K, Kasahara S, Matsushima-Nishiwaki R, Mizuno T, Sakakibara S, Kozawa O.
Significant correlation between the acceleration of platelet aggregation and phosphorylation of HSP27 at Ser-78 in diabetic patients.
Int J Mol Med. 2012;30(6):1387-95.
Doi T, Tokuda H, Matsushima-Nishiwaki R, Cuong NT, Kageyama Y, Iida Y, Kondo A, Akamatsu S, Otsuka T, Iida H, Kozawa O, Ogura S.
Effect of antithrombin III on glycoprotein Ib/IX/V activation in human platelets:suppression of thromboxane A2 generation.
Prostaglandins Leukot Essent Fatty Acids. 2012;87(2-3):57-62.
Tokuda H, Kato K, Natsume H, Kondo A, Kuroyanagi G, Matsushima-Nishiwaki R, Ito Y, Otsuka T, Kozawa O.
Involvement of AMP-activated protein kinase in thrombin-stimuated interleukin-6-synthesis in osteoblasts.
J Mol Endocrinol. 2012;49(1):47-55.
Kondo A, Tokuda H, Mizutani J, Matsushima-Nishiwaki R, Kozawa O, Otsuka T.
Wnt3a upregulates prostaglandin F2α-stimulated vascular endothelial growth factor synthesis in osteoblasts.
Mol Med Rep. 2012;6(2):421-5.
Tanabe K, Matsushima-Nishiwaki R, Iida M, Kozawa O, Iida H.
Involvement of phosphatidylinositol 3-kinase/Akt on basic fibroblast growth factor-induced glial cell line-derived neurotrophic factor release from rat glioma cells.
Brain Res. 2012;1463:21-9.
Kato K, Tokuda H, Matsushima-Nishiwaki R, Natsume H, Kondo A, Ito Y, Kozawa O, Otsuka T.
AMPK limits IL-1-stimulated IL-6 synthesis in osteoblasts: Involvement of IκB/NF-κB pathway.
Cell Signal. 2012;24(8):1706-12.
Mizutani J, Tokuda H, Matsushima-Nishiwaki R, Kato K, Kondo A, Natsume H, Kozawa O, Otsuka T.
Involvement of AMP-activated protein kinase in TGF-β-stimulated VEGF synthesis in osteoblasts.
Int J Mol Med. 2012;29(4):550-6.
Kato K, Otsuka T, Kondo A, Matsushima-Nishiwaki R, Natsume H, Kozawa O, Tokuda H.
AMP-activated protein kinase regulates PDGF-BB-stimulated interleukin-6 synthesis in osteoblasts: involvement of mitogen-activated protein kinases.
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近藤剛弘、西脇理英、堀内　正、曽田　翠、合田和史、寺町ひとみ、土屋照雄
漢方煎薬の煎じ条件に関する患者アンケート調査.
社会薬学(Jpn. Soc. Pharm.) Vol.30, No.1, 2011
Nakashima M, Adachi S, Yasuda I, Yamauchi T, Kawaguchi J, Itani M, Yoshioka T, Matsushima-Nishiwaki R, Hirose Y, Kozawa O, Moriwaki H.
Phosphorylation status of heat shock protein 27 plays a key role in gemcitabine-induced apoptosis of pancreatic cancer cells.
Cancer Lett 2011;313(2):218-25.
Kato K, Otsuka T, Matsushima-Nishiwaki R, Natsume H, Kozawa O, Tokuda H.
Role of HSP27 in tumor necrosis factor-α-stimulated interleukin-6 synthesis in osteoblasts.
Int J Mol Med. 2011;28(5):887-93.
Kato K, Otsuka T, Matsushima-Nishiwaki R, Natsume H, Kozawa O, Tokuda H.
Rho-kinase regulates thrombin-stimulated interleukin-6 synthesis via p38 mitogen-activated protein kinase in osteoblasts.
Int J Mol Med. 2011;28(4):653-8.
Kato K, Otsuka T, Matsushima-Nishiwaki R, Natsume H, Kozawa O, Tokuda H.
Rho-kinase regulates thrombin-stimulated interleukin-6 synthesis via p38 mitogen-activated protein kinase in osteoblasts.
Int J Mol Med. 2011;28(4):653-8.
Matsushima-Nishiwaki R, Adachi S, Yoshioka T, Yasuda E, Yamagishi Y, Matsuura J, Muko M, Iwamura R, Noda T, Toyoda H, Kaneoka Y, Okano Y, Kumada T, Kozawa O.
Suppression by Heat Shock Protein 20 of Hepatocellular Carcinoma Cell Proliferation via Inhibition of the Mitogen-Activated Protein Kinases and AKT Pathways.
J Cell Biochem. 2011;112(11):3430-9.
Natsume H, Tokuda H, Matsushima-Nishiwaki R, Kato K, Yamakawa K, Otsuka T, Kozawa O.
Wnt3a upregulates transforming growth factor-β-stimulated VEGF synthesis in osteoblasts.
Cell Biochem Funct. 2011;29(5):371-7.
Kato K, Otsuka T, Adachi S, Matsushima-Nishiwaki R, Natsume H, Kozawa O, Tokuda H.
(-)-Epigallocatechin gallate inhibits thyroid hormone‑stimulated osteocalcin synthesis in osteoblasts.
Mol Med Rep. 2011;4(2):297-300.
Kato K, Adachi S, Matsushima-Nishiwaki R, Minamitani C, Natsume H, Katagiri Y, Hirose Y, Mizutani J, Tokuda H, Kozawa O, Otsuka T.
Regulation by Heat Shock Protein 27 of Osteocalcin Synthesis in Osteoblasts.
Endocrinology 2011;152(5):1872-82.
Tokuda H, Adachi S, Matsushima-Nishiwaki R, Kato K, Natsume H, Otsuka T, Kozawa O.
Enhancement of basic fibroblast growth factor-stimulated VEGF synthesis by Wnt3a in osteoblasts.
Int J Mol Med. 2011;27(6):859-64.
Enomoto Y, Adachi S, Doi T, Natsume H, Kato K, Matsushima-Nishiwaki R, Akamatsu S, Tokuda H, Yoshimura S, Otsuka T, Ogura S, Kozawa O, Iwama T.
cAMP regulates ADP-induced HSP27 phosphorylation in human platelets.
Int J Mol Med. 2011;27(5):695-700.
Kato K, Tokuda H, Adachi S, Matsushima-Nishiwaki R, Yamauchi J, Natsume H, Minamitani C, Mizutani J, Otsuka T, Kozawa O.
cAMP regulates ADP-induced HSP27 phosphorylation in human platelets.
Int J Mol Med. 2011;27(5):695-700.
Kato K, Tokuda H, Adachi S, Matsushima-Nishiwaki R, Natsume H, Yamakawa K, Gu Y, Otsuka T, Kozawa O.
AMP-activated protein kinase positively regulates FGF-2-stimulated VEGF synthesis in osteoblasts.
Biochem Biophys Res Commun. 2010;400(1):123-7.
Natsume H, Tokuda H, Adachi S, Matsushima-Nishiwaki R, Kato K, Minamitani C, Otsuka T, Kozawa O.
Wnt3a regulates tumor necrosis factor-alpha-stimulated interleukin-6 release in osteoblasts.
Mol Cell Endocrinol. 2011;331(1):66-72.
Tanabe K, Matsushima-Nishiwaki R, Dohi S, Kozawa O.
Phosphorylation status of heat shock protein 27 regulates the interleukin-1beta-induced interleukin-6 synthesis in C6 glioma cells.
Neuroscience. 2010;170(4):1028-34.
Natsume H, Tokuda H, Mizutani J, Adachi S, Matsushima-Nishiwaki R, Minamitani C, Kato K, kozawa O, Otsuka T.
Synergistic effect of vasoactive intestinal peptides on TNF-alpha-induced IL-6 synthesis in osteoblasts: amplification of p44/p42 MAP kinase activation.
Int J Mol Med. 2010;25(5):813-7.
Tokuda H, Adachi S, Matsushima-Nishiwaki R, Hanai Y. Takai S, Harada A, Kozawa O.
Inhibition by minodronate of basic fibroblast growth factor-stimulated vascular endothelial growth factor synthesis in osteoblast-like cells.
Mol Med Rep. 2010;3(1):167-71.
Doi T, Adachi S, Matsushima-Nishiwaki R, Kato H, Enomoto Y, Natsume H, Kato H, Mizutani J, Otsuka T, Tokuda H, Akamatsu S, Iwama T, Kozawa O, Ogura S.
Antithrombin III reduces collagen-stimulated granule secretion of PDGF-AB and the release of soluble CD40 ligand from human platelets.
Int J Mol Med. 2010;26(3):387-92.
Kato K, Tokuda H, Natsume H, Adachi S, Matsushima-Nishiwaki R, Minamitani C, Mizutani J, Kozawa O, Otsuka T.
Rho-kinase regulates prostaglandin D2-stimulated heat shock protein 27 induction in osteoblasts.
Exp Ther Med. 2010;1(4):579–583.
Kato H, Adachi S, Doi T, Matsushima-Nishiwaki R, Minamitani C, Akamatsu S, Enomoto Y, Tokuda H, Otsuka T, Iwama T, Kozawa O, Ogura S.
Mechanism of collagen-induced release of 5-HT, PDGF-AB and CD40L form human platelets: role of HSP27 phosphorylation via p44/p42 MAPK.
Thromb Res. 2010;126(1):39-43.
Tanabe K, Matsushima-Nishiwaki R, Yamaguchi S, Iida H, Dohi S, Kozawa O.
Mechanisms of tumor necrosis factor-alpha-induced interleukin-6 synthesis in glioma cells.
J Neuroinflammation 2010;7:16.
Natsume H, Tokuda H, Adachi S, Takai S, Matsushima-Nishiwaki R, Kato K, Minamitani C, Niida S, Mizutani J, Kozawa O, Otsuka T.
Rho-kinase limits FGF-2 stimulated VEGF release in osteoblasts.
Bone 2010;46(4):1068-74.
Takai S, Tokuda H, Matsushima-Nishiwaki R, Saio M, Takami T, Kozawa O.
TGF-beta superfamily enhances the antigen-induced IFN-gamma production by effector/memory CD8+ T cells.
Int J Mol Med. 2010;25(1):105-11.
Enomoto Y, Adachi S, Matsushima-Nishiwaki R, Doi T, Niwa M, Akamatsu S, Tokuda H, Ogura S, Yoshimura S, Iwama T, Kozawa O.
Thromboxane A2 promotes soluble CD40 ligand release from human platelets.
Atherosclerosis. 2010;209(2):415-21.
Minamitani C , Tokuda H, Adachi S, Matsushima-Nishiwaki R, Yamauchi J, Kato K, Natsume H, Mizutani J, Kozawa O, Otsuka T.
p70 S6 kinase limits tumor necrosis factor-a-induced interleukin-6 synthesis in osteoblasts.
Mol Cell Endocrinol. 2010;315(1-2):195-200.
Hanai Y, Adachi S, Yasuda I, Takai S, Matsushima-Nishiwaki R, Kato H, Enomoto Y, Akamatsu S, Sakakibara S, Ogura S, Iwama T, Kozawa O, Tokuda H.
Collagen-induced p38 MAP kinase activation is a biomarker of platelet hyper-aggregation in patients with diabetes mellitus.
Life Sci. 2009;85(9-10):386-94.
Natsume H, Mizutani J, Adachi S, Matsushima-Nishiwaki R, Minamitani C, Tokuda H, Kozawa O, Otsuka T.
Involvement of Rho-kinase in TGF-beta-stimulated heat shock protein 27 induction in osteoblasts.
Mol Med Rep. 2009;2(5):687-91.
Doi T , Adachi S , Takai S , Matsushima-Nishiwaki R , Kato H , Enomoto Y , Minamitani C, Otsuka T , Tokuda H , Akamatsu S , Iwama T , Kozawa O , Ogura S.
Antithrombin III suppresses ADP-induced platelet granule secretion: inhibition of HSP27 phosphorylation.
Arch Biochem Biophys. 2009;489(1-2):62-7.
Adachi S, Tokuda H, Matsushima-Nishiwaki R, Kato K, Natsume H, Minamitani C, Mizutani J, Otsuka T, Kozawa O.
Involvement of Rho-kinase in prostaglandin E(1)-stimulated VEGF synthesis through stress-activated protein kinase/c-Jun N-terminal kinase in osteoblaset-like MC3T3-E1.
Prostaglandins Other Lipid Mediat. 2009;90(1-2):1-6.
Adachi S, Shimizu M, Shirakami Y, Yamauchi J, Natsume H, Matsushima-Nishiwaki R, To S, Weinstein IB, Moriwaki H, Kozawa O.
(-)-Epigallocatechin gallate downregulates EGF receptor via phosphorylation at Ser1046/1047 by p38 MAP kinase in colon cancer cells.
Carcinogenesis 2009;30(9):1544-52.
Natsume H, Adachi S, Takai S, Tokuda H, Matsushima-Nishiwaki R, Minamitani C, Yamauchi J, Kato K, Mizutani J, Kozawa O, Otsuka T.
(-)-Epigallocatechin gallate attenuates the induction of HSP27 stimulated by sphingosine 1-phosphate via suppression of phosphatidylinositol 3-kinase/Akt pathway in osteoblasts.
Int J Mol Med. 2009;24(2):197-203.
Enomoto Y, Adachi S, Matsushima-Nishiwaki R, Niwa M, Tokuda H, Akamatsu S, Doi T, Kato H, Yoshimura S, Ogura S, Iwama T, Kozawa O.
alphaB-crystallin extracellularly suppresses ADP-induced ganule secretion from human platelets.
FEBS Lett. 2009;583(15):2464-8.
Minamitani C, Otsuka T, Takai S, Matsushima-NIshiwaki R, Adachi S, Hanai Y, Mizutani J, Tokuda H, Kozawa O.
Involvement of Rho-kinase in sphingosine 1-phosphate-stimulated HSP27 induction in osteoblasts.
Int J Mol Med. 2009;24(1):77-82.
Yamaguchi S, Tanabe K, Takai S, Matsushima-Nishiwaki R, Adachi S, Iida H, Kozawa O, Dohi S.
Involvement of Rho-kinase in tumor necrosis factor-alpha-induced interleukin-6 release from C6 glioma cells.
Neurochem Int. 2009;55(6):438-45.
Tokuda H, Harada A, Adachi S, Matsushima-Nishiwaki R, Natsume H, Minamitani C, Mizutani J, Otsuka T, Kozawa O.
Raloxifene enhances spontaneous microaggregation of platelets throughupregulation of p44/p42 MAP kinase: a case report.
Osteoporosis Int. 2010;21(1):189-93.
Adachi S, Natsume H, Yamauchi J, Matsushima-Nishiwaki R, Joe AK, Moriwaki H, Kozawa O.
p38 MAP kinase controls EGF receptor downregulation via phosphorylation at Ser1046/1047.
Cancer Lett. 2009;277(1):108-13.
Takai S, Matsushima-Nishiwaki R, Adachi S, Natsume H, Minamitani C, Mizutani J, Otsuka T, Tokuda H, Kozawa O.
(-)-Epigallocatechin gallate reduces platelet-derived growth factor-BB-stimulated interleukin-6 synthesis in osteoblasts: suppression of SAPK/JNK.
Mediators Inflamm. 2008:2008:291808.
Yamauchi J, Takai S, Matsushima-Nishiwaki R, Adachi S, Minamitani C, Natsume H, Mizutani J, Otsuka T, Takeda J, Harada A, Kozawa O, Tokuda H.
Tacrolimus but not cyclosporine A enhances FGF-2-induced VEGF release in osteoblasts.
Int J Mol Med. 2009 Feb;23(2):267-72.
Kuno M, Takai S, Matsushima-Nishiwaki R, Harada A, Adachi S, Kozawa O, Tokuda H.
Rho-kinase inhibitors decrease TGF-β-stimulated VEGF synthesis through stress-activated protein kinase/c-Jun N-terminal kinase in osteoblasts.
Biochem Pharmacol. 2009;77(2):196-203.
Tokuda H, Takai S, Matsushima-Nishiwaki R, Hanai Y, Adachi S, Minamitani C, Mizutani J, Otsuka T, Kozawa O.
Function of Rho-kinase in prostaglandin D2-induced interleukin-6 synthesis in osteoblasts.
Prostaglandins Leukot Essent Fatty Acids. 2008;79(1-2):41-6.
Tokuda H, Takai S, Hanai Y, Matsushima-Nishiwaki R, Yamauchi J, Harada A, Hosoi T, Ohta T, Kozawa O.
(-)-Epigallocatechin gallate inhibits basic fibroblast growth factor-stimulated interleukin-6 synthesis in osteoblasts.
Horm Metab Res. 2008;40(10):674-8.
Tokuda H, Takai S, Hanai Y, Harada A, Matsushima-Nishiwaki R, Kato H, Ogura S, Kozawa O.
Potentiation by platelet-derived growth factor-BB of FGF-2-stimulated VEGF release in osteoblasts.
J Bone Miner Metab. 2008;26(4):335-41.
Minamitani C, Takai S, Matsushima-Nishiwaki R, Hanai Y, Otsuka T, Kozawa O, Tokuda H.
Raloxifene-induced acceleration of platelet aggregation.
Intern Med. 2008;47(17):1523-8.
Adachi S, Nagao T, To S, Joe AK, Shimizu S, Matsushima-Nishiwaki R, Kozawa O, Moriwaki H, Maxfield FR, Weinstein IB.
(-)Epigallocatechin gallate causes internalization of the epidermal growth factor receptor in human colon cancer cells.
Carcinogenesis. 2008;29(10):1986-93.
Minamitani C, Otsuka T, Takai S, Matsushima-Nishiwaki R, Adachi S, Hanai Y, Mizutani J, Tokuda H, Kozawa O.
Involvement of Rho-kinase in prostaglandin F2α-stimulated interleukin-6 synthesis via p38 mitogen-activated protein kinase in osteoblast.
Mol Cell Endocrinol. 2008;291(1-2):27-32.
Matsushima-Nishiwaki R, Takai S, Adachi S, Minamitani C, Yasuda E, Noda T, Kato K, Toyoda H, Kaneoka Y, Yamaguchi A, Kumada T, Kozawa O.
Phosphorylated heat shock protein 27 represses growth of hepatocellular carcinoma via inhibition of extracellular-signal-regulated kinase.
J Biol Chem. 2008;283(27):18852-60.
Kato H, Takai S, Matsushima-Nishiwaki R, Adachi S, Minamitani C, Otsuka T, Tokuda H, Akamatsu S, Doi T, Ogura S, Kozawa O.
HSP27 phosphorylation is correlated with ADP-induced platelet granule secretion.
Arch Biohem Biophys. 2008;475(1):80-6.
Hayashi K, Takai S, Matsushima-Nishiwaki R, Hanai Y, Kato K, Tokuda H, Kozawa O.
(-)-Epigallocatechin gallate reduces transforming growth factor beta-stimulated HSP27 induction through the suppression of stress-activated protein kinase/c-Jun N-terminal kinase in osteoblasts.
Life Sci. 2008;82(19-20):1012-7.
Tanabe K, Takai S, Matsushima-Nishiwaki R, Kato K, Dohi S, Kozawa O.
alpha(2) Adenoreceptor agonist regulates protein kinase C-induced heat shock protein 27 phosphorylation in C6 glioma cells.
J Neurochem. 2008;106(2):519-28.
Takai S, hanai Y, Matsushima-Nishiwaki R, Minamitani C, Otsuka T, Tokuda H, Kozawa O.
p70 S6 kinase negatively regulates fibroblast growth factor 2-stimulated interleukin-6 synthesis in osteoblasts: function at a point downstream from protein kinase C.
J Endocrnol. 2008;197(1):131-7.
Tokuda H, Takai S, Hanai Y, Harada A, Matsushima-Nishiwaki R, Akamatsu S, Ohta T, Kozawa O.
Platelet-derived growth factor-BB amplifies PGF2alpha-stimulated VEGF synthesis in osteoblasts: funtion of phosphatidylinositol 3-kinase.
Prostaglandins Leukot Essent Fatty Acids. 2007;77(3-4):187-93.
Kanemura N, Tsurumi H, Okuno M, Matsushima-Nishiwaki R, Shimizu M, Moriwaki H.
Retinoid X receptor alpha is highly phosphorylated in retinoic acid-resistant HL-60R cells and the combination of 9-cis retinoic acid plus MEK Inhibitor induces apoptosis in the cells.
Leukemia Res. 2008;32(6):884-92.
Yoshimura K, Muto Y, Shimizu M, Matsushima-Nishiwaki R, Okuno M, Takano Y, Tsurumi H, Kojima, S Okano Y, Moriwaki H.
Phosphorylated retinoid X receptor alpha loses its heterodimeric activity with retinoic acid receptor beta.
Cancer Sci. 2007;98(12):1868-74.
Yamazaki K, Shimizu M, Okuno M, Matsushima-Nishiwaki R, Kanemura N, Araki H, Tsurumi H, Kojima S, Weinstein IB, Moriwaki H.
Synergistic effects of RXR-alpha and PPAR-gamma ligands to inhibit growth in human colon cancer cells phosphorylated RXR-alpha is a critical target for colon cancer management.
Gut. 2007;56(11):1557-63.
Ando H, Shimizu M, Okuno M, Matsushima-Nishiwaki R, Tsurumi H, Tanaka T, Moriwaki H.
Expression of retinoid X receptor α is decreased in 2’-methyl-4-dimethylaminoazobenzene-induced hepatocellular carcinoma in rats.
Oncol Rep. 2007;18(4):879-84.
Tokuda H,, Hanai Y, Matsushima-Nishiwaki R, Yamauchi J, Doi T, Harada A, Takai S, Kozawa O.
Rho-kinase regulates endothelin-1-stimulated IL-6 synthesis via p38 MAP kinase in osteoblasts.
Biochem Biophys Res Commun. 2007;362(4):799-804.
Yamauchi J, Takai S, Matsushima-Nishiwaki R, Hanai Y, Doi T, Kato H, Ogura S, Kato K, Tokuda H, Kozawa O.
(-)-Epigallocatechin gallate inhibits prostaglandin D2-stimulated HSP27 induction via suppression of the p44/p42 MAP kinase pathway in pstepblasts.
Prostaglandins Leukot Essent Fatty Acids. 2007;77(3-4):173-9.
Takai S, Matsushima-Nishiwaki R, Tokuda H, Yasuda E, Toyoda H, Kaneoka Y, Yamaguchi A, Kumada T, Kozawa O.
Protein kinase C delta regulates the phosphorylation of heat shock protein 27 in human hepatocellular carcinoma.
Life Sci. 2007;81(7):585-91.
Ochiai S, Sekiguchi S, Hayashi A, Shimadzu M, Ishiko H, Matsushima-Nishiwaki R, Kozawa O, Yasuda M, Deguchi T.
Decreased affinity of mosaic-structure recombinant penicillin-binding protein 2 for oral cephalosporins in Neisseria genorrhoeae.
J Antimicrob Chemoth. 2007;60(1):54-60.
Noda T, Kumada T, Takai S, Matsushima-Nishiwaki R, Yoshimi N, Yasuda E, Kato K, Toyoda H, Kaneoka Y, Yamaguchi A, Kozawa O.
Expression levels of heat shock protein 20 decrease in parallel with tumor progression in patients with hepatocellular carcinoma.
Oncol Rep. 2007;17(6):1309-14.
Kanamori T, Shimizu M, Okuno M, Matsushima-Nishiwaki R, Tsurumi H, Kojima S, Moriwaki H.
Synergistic growth inhibition by acyclic retinoid and vitamin K(2) in human hepatocellular carcinoma cells.
Cancer Sci. 2007;98(3):431-7.
Tokuda H, Takai S, Matsushima-Nishiwaki R, Akamatsu S, Hanai Y, Hosoi T, Harada A, Ohta T, Kozawa O.
(-)-Epigallocatechin gallate suppresss endothelin-1-induced interleukin-6 synthesis in osteoblasts: inhibition of p44/p42 MAP kinase activation.
FEBS lett. 2007;581(7):1311-6.
Takai S, Tokuda H, Hanai Y, Harada A, Yasuda E, Matsushima-Nishiwaki R, Kato H, Ogura S, Kozawa O.
Negative regulation by p70 S6 kinase of FGF-2-stimulated VEGF release through stress-activated protein kinase/c-jun N-terminal kinase in osteoblasts.
J Bone Miner Res. 2007;22(3):337-46.
Tokuda H, Takai S, Matsushima-Nishiwaki R, Akamatsu S, Hanai Y, Hosoi T, Harada A, Ohta T, Kozawa O.
(-)-Epigallocatechin gallate enhances prostaglandin F2α-inguced VEGF sysnthasis via up-regulating SAPK/JNK activation in osteoblasts.
J Cell Biochem. 2007;100(5):1146-53.
Takai S, Tokuda H, Yoshida M, Yasuda E, Matsushima-Nishiwaki R, Harada A, Kato K, Kozawa O.
Prostaglandin D2 in duces the phosphorylation of HSP27 in osteoblasts: Function of the MAP kinase superfamily.
Prostaglandins Leukot Essent Fatty Acids. 2006;75(2):61-7.
Hanai Y, Tokuda H, Ohta T, Matsushima-Nishiwaki R, Takai S, Kozawa O.
Phosphatidylinositol 3-kinase/Akt auto-regulates PDGF-BB-stimulated interleukin-6 synthesis in osteoblasts.
J Cell Biochem. 2006;99(6):1564-71.
Hanai Y, Tokuda H, Ishisaki A, Matsushima-Nishiwaki R, Nakamura N, Yoshida M, Takai S, Ohta T, Kozawa O.
Involvement of p44/p42 MAP kinase in insulin-like growth factor-I-induced alkaline phosphatase activity in osteoblast-like MC2T3-E1 cells.
Mol Cell Endocrinol. 2006;251(1-2):42-8.
Takai S, Tokuda H, Matsushima-Nishiwaki R, Hanai Y, Kato K, Kozawa O.
Phosphatidylinositol-3-kinase/Akt plays a role in sphingosine 1-phosphate-stimulated HSP27 induction in osteoblasts.
J Cell Biochem. 2006;98(5):1249-56.
Tanabe K, Tokuda H, Takai S, Matsushima-Nishiwaki R, Hanai Y, Hirade K, Katagiri Y, Dohi S, Kozawa O.
Modulation by the steroid/thyroid hormone superfamily of TGF-beta stimulated VEGF release from vascular smooth muscle cells.
J Cell Biochem. 2006;99(1):187-95.
Yasuda E, Kumada T, Takai S, Ishisaki A, Noda T, Matsushima-Nishiwaki R, Yoshimi N, Kato K, Toyoda H, Kaneoka Y, Yamaguchi A, Kozawa O.
Attenuated Phosphorylation of Heat Shock Protein 27 Correlates with Tumor Progression in Patients with Hepatocellular Carcinoma.
Biochem Biophys Res Commun. 2005;337(1):337-42.
Sano T, Kagawa M, Okuno M, Ishibashi N, Hashimoto M, Yamamoto M, Suzuki R, Kohno H, Matsushima-Nishiwaki R, Takano Y, Tsurumi H, Kojima S, Friedman SL, Moriwaki H, Tanaka T.
Prevention of Rat Hepatocarcinogenesis by Acyclic Retinoid Is Accompanied by Reduction in Emergence of Both TGF-alpha-Expressing Oval-Like Cells and Activated Hepatic Stellate Cells.
Nutr Cancer. 2005;51(2):197-206.
Takai K, Okuno M, Ichiro Y, Matsushima-Nishiwaki R, Uematsu T, Tsurumi H, Shiratori Y, Muto Y, Moriwaki H.
Prevention of second primary tumors by an acyclic retinoid in patients with hepatocellular carcinoma.
Intervirology. 2005;48(1):39-45.
Takano Y, Adachi S, Okuno M, Muto Y, Yoshioka T, Matsushima-Nishiwaki R, Tsurumi H, Ito K, Friedman SL, Moriwaki H, Kojima S, Okano Y.
The RING-finger protein, RNF8, interacts with retinoid X receptor alpha and enhances its transcription-stimulating activity.
J Biol Chem. 2004;279(18):18926-34.
西脇理英、奥野正隆、高野幸彦、小嶋聡一、森脇久隆
非環式レチノイドによる肝がん細胞増殖抑制の分子機構
ビタミン、2003;77:601-602.
Matsushima-Nishiwaki R, Okuno M, Takano Y, Kojima S, Friedman SL, Moriwaki H.
Molecular mechanism for growth suppression of human hepatocellular carcinoma cells by acyclic retinoid.
Carcinogenesis. 2003;24(8):1353-9.
奥野正隆、西脇理英、足立政治、高野幸彦、小嶋聡一、森脇久隆
ヒト肝細胞癌におけるリン酸化レチノイドＸレセプターの機能と代謝の異常
ビタミン、2002;76:469-471.
Obora A, Shiratori Y, Okuno M, Adachi S, Takano Y, Matsushima-Nishiwaki R, Yasuda I, Yamada Y, Akita K, Sano T, Shimada J, Kojima S, Okano Y, Friedman SL, Moriwaki H.
Synergistic induction of apoptosis by acyclic retinoid and interferon-beta in human hepatocellular carcinoma cells.
Hepatology. 2002;36(5):1115-24.
Adachi S, Okuno M, Matsushima-Nishiwaki R, Takano Y, Kojima S, Friedman SL, Moriwaki H, Okano Y.
Phosphorylation of retinoid X receptor suppresses its ubiquitination in human hepatocellular carcinoma.
Hepatology. 2002;35(2):332-40.
Okuno M, Sano T, Matsushima-Nishiwaki R, Adachi S, Akita K, Okano Y, Kojima S, Moriwaki H.
Apoptosis induction by acyclic retionid: a molecular basis of 'clonal deletion' therapy for hepatocellular carcinoma.
Jpn J Clin Oncol. 2001;31(8):359-62.
Matsushima-Nishiwaki R, Okuno M, Adachi S, Sano T, Akita K, Friedman SL, Moriwaki H, Kojima S.
Phosphorylation of retinoid X receptor alpha at serine 260 impairs its metabolism and function in human hepatocellular carcinoma.
Cancer Res. 2001;61(20):7675-82.
Onogi N, Okuno M, Matsushima-Nishiwaki R, Hukutomi Y, Moriwaki H, Muto Y, Kojima S.
Antiproliferative effect of carotenoids on human colon cancer cells without conversion to retinoic acid.
Nutr Cancer. 1998;32(1):20-4.
Matsushima-Nishiwaki R, Shidoji Y, Nishiwaki S, Moriwaki H, Muto Y.
Limited degradation of retinoid X receptor by calpain.
Biochem Biophys Res commun. 1996;225(3):946-51.
Matsushima-Nishiwaki R, Shidoji Y, Nishiwaki S, Yamada T, Moriwaki H, Muto Y.
Aberrant metabolism of retinoid X receptor proteins on human hepatocellular carcinoma.
Mol Cell Endocrinol. 1996;121(2):179-90.
Suganuma M, Okabe S, Sueoka E, Nishiwaki R, Komori A, Uda N, Isono K, Fujiki H.
Tautomycin: an inhinitor of protein phosphatases 1and 2A but not a tumor promoter on mouse skin and rat glandular stomach.
J Cancer Res Clin Oncol. 1995;121(9-10):621-7.
Matsushima-Nishiwaki R, Shidoji Y, Nishiwaki S, Yamada T, Moriwaki H, Muto Y.
Suppression by carotenoids of microcystin-induced morphological changes in mouse hepatocytes.
Lipids. 1995;30(11):1029-34.
Ohta T, Sueoka E, Iida N, Komori A, Suganuma M, Nishiwaki R, Tatematsu M, Kim SJ, Carmichael WW, Fujiki H.
Nodularin, a potent inhibitor of protein phosphatases 1 and 2A, is a new environmental　carcinogen in male F344 rat liver.
Cancer Res. 1994;54(24):6402-6.
Nishiwaki R, Ohta T, Sueoka E, Suganuma M, Harada K, Watanabe MF, Fujiki H.
Two significant aspects of microcystin-LR specific binding and liver specificity.
Cancer Letters. 1994;83(1-2):283-9.
Ohta T, Nishiwaki R, Yatsunami Y, Komori A, Suganuma M, Fujiki H.
Hyperphosphorylation of cytokeratins 8 and 18 by microcystin-LR, a new liver-tumor promoter, in primary rat heptaocytes.
Carcinogenesis. 1992;13(12):2443-7.
Nishiwaki-Matsushima R, Fujiki H, Harada K, Taylor C, Quinn RJ.
The role of arginine in interactions of microcystins with protein phosphatases 1 and 2A.
Bioorg Medicinal Chemistry Lett. 1992;7:63-676.
Taylor C, Quinn RJ, McClloch R, Nishiwaki-Matsushima R, Fujiki H.
An alternative computer model of the 3-dimensional structures of microcystin-LR and nodularin rationalising their interactions with protein phosphatases 1 and 2A.
Bioorg Medicinal Chemistry Lett. 1992;2:299-302.
Nishiwaki-Matsushima R, Ohta T, Nishiwaki S, Suganuma M, Kohyama K, Ishikawa T, Carmichael WW, Fujiki H.
Liver tumor promotion by the cyanobacterial cyclic prptide toxin microcystin-LR.
J Cancer Res Clin Oncol. 1992;118(6):420-4.
Nishiwaki S, Fujiki H, Suganuma M, Nishiwaki-Matsushima R, Sugimura T.
Rapid purification of protein phosphatase 2A from mouse brain by microcystin-affinity chromatography.
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研究業績

兵藤 文紀

西脇 理英

白水 翔也

研究業績

兵藤文紀

西脇理英

白水翔也