東海国立大学機構 岐阜大学 糖鎖生命コア研究所 (iGCORE)糖鎖分子科学研究センター 糖鎖分析化学研究室 Institue for Glyco-core Research (iGCORE), Glycoanalytical Chemistry Lab.

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研究業績

学術論文

2024年

  1. Aguilera-Correa JJ, Wei F, Leclercq LD, Tasrini Y, Mullapudi E, Daher W, Nakajima K, Canaan S, Herrmann JL, Wilmanns M, Guérardel Y, Wen L, Kremer L.
    A dTDP-L-Rhamnose 4-epimerase required for glycopeptidolipid biosynthesis in Mycobacterium abscessus.
    J Biol Chem .2024, In press.
  2. Yamada.K, Asada K, Hanzawa K, Aoki Y, Nakajima K, Kinoshita M.
    Developing method for minor acidic O-Glycan analysis in mucin and cancer cell samples.
    J Proteome Res. 2024, 23(10):4254-4272.
  3. Aoki-Kinoshita KF, Ando H, Angata K, Fujita M, Furukawa JI, Kaji H, Kato K, Kitajima K, Kizuka Y, Matsui Y, Nakajima K, Nishihara S, Okajima T, Sakamoto K, Sato C, Thaysen-Andersen M, Togayachi A, Yagi H, Kadomatsu K.
    The Human Glycome Atlas Project for cataloging all glycan-related omics data in human.
    Glycobiology. 2024, cwae052.
  4. Hashimoto Y, Kawade H, Bao W, Morii S, Nakano M, Nagae M, Murakami R, Tokoro Y, Nakashima M, Cai Z, Isaji T, Gu J, Nakajima K, Kizuka Y.
    The K346T mutant of GnT-III bearing weak in vitro and potent intracellular activity.
    Biochim Biophys Acta Gen Subj. 2024, 130663.
  5. Zhang R, Farshadyeganeh P, Ohkawara B, Nakajima K, Takeda JI, Ito M, Zhang S, Miyasaka Y, Ohno T, Mori-Yoshimura M, Masuda A, Ohno K.
    Muscle-specific lack of GFPT1 in knock-in mice triggers ER stress to alleviate misfolded proteins.
    Dis Model Mech. 2024, dmm, 050768.
  6. Iwamoto S, Kobayashi T, Hanamatsu H, Yokota I, Teranishi Y, Iwamoto A, Kitagawa M, Ashida S, Sakurai A, Matsuo S, Myokan Y, Sugimoto A, Ushioda R, Nagata K, Gotoh N, Nakajima K, Nishikaze T, Furukawa J, Itano N.
    Tolerable glycometabolic 1 stress boosts cancer cell resilience through altered N-glycosylation and Notch signaling activation.
    Cell Death Dis. 2024, 5(1), 53.

2023年

  1. Farshadyeganeh P,Nazim M,Zhang R,Ohkawara B,Nakajima K,Rahman MA,Nasrin F,Ito M,Takeda J,Ohe K,Miyasaka Y,Ohno T,Masuda A,Ohno K.
    Splicing regulation of GFPT1 muscle-specific isoform and its roles in glucose metabolisms and neuromuscular junction.
    iScience. 2023, 26(10), 107746.
  2. Saitoh S, Takaki T, Nakajima K, Wo B, Terashima H, Shimo S, Nguyen HB, Thai TQ, Kumamoto K, Kunisawa K, Nagao S, Tojo A, Ohno N, Takahashi K.
    Treatment of tubular damage in high-fat-diet-fed obese mice using sodium-glucose co-transporter inhibitors.
    PLoS One. 2023, 18(2), e0281770.

2022年

  1. Ohyama Y, Yamaguchi H, Ogata S, Chiurlia S, Cox SN, Kouri NM, Stangou MJ, Nakajima K, Hayashi H, Inaguma D, Hasegawa M, Yuzawa Y, Tsuboi N, Renfrow MB, Novak J, Papagianni AA, Schena FP, Takahashi K.
    Racial heterogeneity of IgA1 hinge-region O-glycoforms in patients with IgA nephropathy.
    iScience. 2022, 25(11),105223.
  2. Umezawa F, Natsume M, Fukusada S, Nakajima K, Yamasaki F, Kawashima H, Kuo CW, Khoo KH, Shimura T, Yagi H, Kato K.
    Cancer malignancy is correlated with upregulation of PCYT2-mediated glycerol phosphate modification of α-dystroglycan.
    Int. J. Mol. Sci. 2022, 23(12), 6662.
  3. Koseki T, Nakajima K, Iwasaki H, Yamada.S, Takahashi K, Doi Y, Mizuno T.
    Baseline uric acid levels and steady-state favipiravir concentrations are associated with occurrence of hyperuricemia among COVID-19 patients.
    Int. J. Infect. Dis. 2022, 115, 218-23.
  4. Kidoguchi S, Kitada K, Nakajima K, Nakano D, Ohsaki H, Kittikulsuth W, Kobara H, Masaki T, Yokoo T, Takahashi K, Titze J, Nishiyama A.
    Hepatocellular carcinoma induces body mass loss in parallel with osmolyte and water retention in rats.
    Life Sci. 2022, 289, 120192.

2021年

  1. Ryuge A, Kosugi T, Maeda, Banno R, Gou Y, Zaitsu K, Ito T, Sato Y, Hirayama A, Tsubota S, Honda T, Nakajima K, Ozaki T, Kondoh K, Takahashi K, Kato N, Ishimoto T, Soga T, Nakagawa T, Koike T, Arima H, Yuzawa Y, Minokoshi Y, Maruyama S, Kadomatsu K.
    Basigin deficiency prevents anaplerosis and ameliorates insulin resistance and hepatic steatosis.
    JCI Insight. 2021, 6(20), e142464.
  2. Kinoshita M, Nakajima K, Yamamoto S, Suzuki S.
    High-throughput N-glycan screening method for therapeutic antibodies using a microchip-based DNA analyzer: a promising methodology for monitoring monoclonal antibody N-glycosylation.
    Anal. Biol. Chem. 2021, 413(19), 4727-38. (Paper in Forefront)
  3. Kitano M, Kizuka Y, Sobajima T, Nakano M, Nakajima K, Misaki R, Itoyama S, Harada Y, Harada A, Miyoshi E, Taniguchi N.
    Rab11-mediated post-Golgi transport of the sialyltransferase ST3GAL4 suggests a new mechanism for regulating glycosylation.
    J. Biol. Chem. 2021, 296, 100354. (Editors' Pick)

2020年

  1. *Harada Y, *Nakajima K, *Li S, Suzuki T, Taniguchi N.
    Protocol for Analyzing the Biosynthesis and Degradation of N-glycan Precursors in Mammalian Cells,
    STAR Protocols. 2020, 2(1), 100316. (*Equal Contributions)
  2. Harada Y, Nakajima K, Suzuki T, Fukushige T, Kondo K, Seino J, Ohkawa Y, Suzuki T, Inoue H, Kanekura T, Taniguchi N, Maruyama I.
    Glycometabolic regulation of the biogenesis of small extracellular vesicles.
    Cell Reports. 2020, 33(2), 108261.
  3. Fukuda Y, Nakajima K, Mutoh T.
    Neuroprotection by neurotropin through crosstalk of neurotrophic and innate immune receptors in PC12 Cells.
    Int. J. Mol. Sci. 2020, 21(18), 6456.
  4. Ma C, Takeuchi H, Hao H, Yonekawa C, Nakajima K, Nagae M, Okajima T, Haltiwanger RS, Kizuka Y.
    Differential labeling of glycoproteins with alkynyl fucose analogs.
    Int. J. Mol. Sci. 2020, 21(17), 6007.
  5. Ohyama Y, Yamaguchi H, Nakajima K, Mizuno T, Fukamachi Y, Yokoi Y, Tsuboi N, Inaguma D, Hasegawa M, Renfrow MB, Novak J, Yuzawa Y, Takahashi K.
    Analysis of O-glycoforms of the IgA1 hinge region by sequential deglycosylation.
    Sci. Rep. 2020, 10(1), 671.

2019年

  1. Hirayama H, Matsuda T, Tsuchiya Y, Oka R, Seino J, Huang C, Nakajima K, Noda Y, Shichino Y, Iwasaki S, Suzuki T.
    Free glycans derived from O-mannosylated glycoproteins suggest the presence of an O-glycoprotein degradation pathway in yeast.
    J. Biol. Chem. 2019, 294(44), 15900-11.
  2. Nakano M, Mishra SK, Tokoro Y, Sato K, Nakajima K, Yamaguchi Y, Taniguchi N, Kizuka Y.
    Bisecting GlcNAc Is a General Suppressor of Terminal Modification of N-glycan.
    Mol. Cell Proteomics. 2019, 18(10), 2044-57.

2018年

  1. Nakajima K, Kizuka Y, Yamaguchi Y, Hirabayashi Y, Takahashi K, Yuzawa Y, Taniguchi N.
    Identification and characterization of UDP-mannose in human cell lines and mouse organs: differential distribution across brain regions and organs.
    Biochem. Biophys. Res. Commun. 2018, 495(1), 401-7.
  2. Kondo A, Takahashi K, Yamaguchi H, Yoshida Y, Mizuno T, Nakajima K, Hayashi H, Koide S, Inaguma D, Hasegawa M, Hiki Y, Yuzawa Y.
    Mass spectrometry-based approach for development of biomarkers in IgA nephropathy: a pilot trial.
    Fujita Medical Journal. 2018, 4(2), 36-41.

2017年以前

  1. Kizuka Y, Nakano M, Yamaguchi Y, Nakajima K, Oka R, Sato K, Ren CT, Hsu TL, Wong CH, Taniguchi. N.
    An alkynyl-fucose halts hepatoma cell migration and invasion by inhibiting GDP-Fucose synthesizing enzyme FX.
    Cell Chem. Biol. 2017, 24(12), 1467-78.
  2. Nakajima K, Akiyama H, Tanaka K, Kohyama A, Greimel P, Hirabayashi Y.
    Separation and analysis of mono-glucosylated lipids in brain and skin by hydrophilic interaction chromatography based on carbohydrate and lipid moiety.
    J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 2016, 1031, 146-53.
  3. Kizuka Y, Funayama S, Shogomori H, Nakano M, Nakajima K, Oka R, Kitazume S, Yamaguchi Y, Sano M, Korekane H, Hsu TL, Lee HY, Wong CH, Taniguchi. N.
    High-sensitivity and low-toxicity fucose probe for glycan imaging and biomarker discovery.
    Cell Chem. Biol. 2016, 23(7), 782-92.
  4. Akiyama H, Nakajima K, Itoh Y, Sayano T, Ohashi Y, Yamaguchi Y, Greimel P, Hirabayashi Y.
    Aglycon diversity of brain sterylglucosides: Structure determination of cholesteryl- and sitosterylglucoside.
    J. Lipid. Res. 2016, 57(11), 2061-72.
  5. Chanmee T, Ontong P, Izumikawa T, Higashide M, Mochizuki N, Chokchaitaweesuk C, Khansai M, Nakajima K, Kakizaki I, Kongtawelert P, Taniguchi N, Itano N.
    Hyaluronan production regulates metabolic and cancer stem-like properties of breast cancer cells via hexosamine biosynthetic pathway-coupled HIF-1 signaling.
    J. Biol. Chem. 2016, 291(46), 24105-20.
  6. Suzuki M, Fujikake N, Takeuchi T, Kohyama-Koganeya A, Nakajima K, Hirabayashi Y, Wada K, Nagai Y.
    Glucocerebrosidase deficiency accelerates the accumulation of proteinase K-resistant α-synuclein and aggravates neurodegeneration in a Drosophila model of Parkinson's disease.
    Hum. Mol. Genet. 2015, 24(23), 6675-86.
  7. Yang YR, Kim DH, Seo YK, Park D, Jang HJ, Choi SY, Lee YH, Lee GH, Nakajima K, Taniguchi N, Choi EJ, Moon HY, Kim IS, Choi JH, Lee H, Ryu SH, Cocco L, Suh, PG.
    Elevated O-GlcNAcylation promotes colonic inflammation and tumorigenesis by modulating.
    Oncotarget. 2015, 6(14), 12529-42.
  8. Okahara K, Kizuka Y, Kitazume S, Ota F, Nakajima K, Hirabayashi Y, Yoshikawa T, Taniguchi N.
    Ceramide galactosyltransferase expression is regulated positively by Nkx2.2 and negatively by OLIG2.
    Glycobiology. 2014, 24(10), 926-34.
  9. Kurimoto A, Kitazume S, Kizuka Y, Nakajima K, Oka R, Fujinawa R, Korekane H, Yamaguchi Y, Wada Y, Taniguchi N.
    The absence of core fucose up-regulates GnT-III and Wnt target genes: a possible mechanism for an adaptive response in terms of glycan function.
    J. Biol. Chem. 2014, 289(17), 11704-14.
  10. Nakajima K, Ito E, Ohtsubo K, Shirato K, Takamiya R, Kitazume S, Angata T, Taniguchi N.
    Mass isotopomer analysis of metabolically labeled nucleotide sugars and N- and O-glycans for tracing nucleotide sugar metabolisms.
    Mol. & Cell Proteomics. 2013, 12(9), 2468-80.
  11. Harada Y, Nakajima K, Masahara-Negishi Y, Freeze HH, Angata T, Taniguchi N, and Suzuki T.
    Metabolically programmed quality control system for dolichol-linked oligosaccharides.
    Proc. Natl. Acad. Sci. U.S.A. 2013, 110(48), 19366-71.
  12. Korekane H, Park JY, Matsumoto A, Nakajima K, Takamatsu S, Ohtsubo K, Miyamoto Y, Hanashima S, Kanekiyo K, Kitazume S, Yamaguchi Y, Matsuo I, Taniguchi N.
    Identification of ectonucleotide pyrophosphatase/phosphodiesterase 3 (ENPP3) as a regulator of N-acetylglucosaminyltransferase GnT-IX (GnT-Vb).
    J. Biol. Chem. 2013, 288(39), 27912-26.
  13. Ito E, Nakajima K, Waki H, Miseki K, Shimada T, Sato TA, Kakehi K, Suzuki M, Taniguchi N, Suzuki A.
    Structural characterization of pyridylaminated oligosaccharides derived from neutral glycosphingolipids by high-sensitivity capillary electrophoresis-mass spectrometry.
    Anal. Chem. 2013, 85(16), 7859-65.
  14. Ito E, Tominaga A, Waki H, Miseki K, Tomioka A, Nakajima K, Kakehi K, Suzuki M, Taniguchi N, Suzuki A.
    Structural characterization of monosialo-, disialo- and trisialo-gangliosides by negative ion AP-MALDI-QIT-TOF mass spectrometry with MS(n) switching.
    Neurochem. Res. 2012, 37(6), 1315-24.
  15. Nakajima K, Kitazume S, Angata T, Fujinawa R, Ohtsubo K, Miyoshi E, Taniguchi, N.
    Simultaneous determination of nucleotide sugars with ion-pair reversed-phase HPLC.
    Glycobiology. 2010, 20(7), 865-71.
  16. Dang F, Maeda E, Osafune T, Nakajima K, Kakehi K, Ishikawa M, Baba Y.
    Carbohydrate-protein interactions investigated on plastic chips statically coated with hydrophobically modified hydroxyethylcellulose.
    Anal. Chem. 2009, 81(24), 10055-60.
  17. Kinoshita M, Ohta H, Higaki K, Kojima Y, Urashima T, Nakajima K, Suzuki M, Kovacs KM, Lydersen C, Hayakawa T, Kakehi K.
    Structural characterization of multibranched oligosaccharides from seal milk by a combination of off-line HPLC MALDI TOF-MS and sequential exoglycosidase digestion.
    Anal. Biochem. 2009, 388(2), 242-53.
  18. Nakajima K, Kinoshita M, Matsushita N, Urashima T, Suzuki M, Suzuki A, Kakehi K.
    Capillary affinity electrophoresis using lectins for the analysis of milk oligosaccharide structure and its application to bovine colostrum oligosaccharides.
    Anal. Biochem. 2006, 348(1), 105-14.
  19. Dang F, Kakehi K, Nakajima K, Shinohara Y, Ishikawa M, Kaji N, Tokeshi M, Baba Y.
    Rapid analysis of oligosaccharides derived from glycoproteins by microchip electrophoresis.
    J. Chromatogr. A. 2006, 1109(2), 138-43.
  20. Dang F, Kakehi K, Cheng J, Tabata O, Kurokawa M, Nakajima K, Ishikawa M, Baba Y.
    Hybrid dynamic coating with n-dodecyl beta-D-maltoside and methyl cellulose for high-performance carbohydrate analysis on poly(methyl methacrylate) chips.
    Anal. Chem. 2006, 78(5), 1452-8.
  21. Nakajima K, Kinoshita M, Oda Y, Masuko T, Kaku H, Shibuya N, Kakehi K.
    Screening method of carbohydrate-binding proteins in biological source by capillary affinity electrophoresis and its application to determination of Tulipa gesneriana agglutinin in tulip bulbs.
    Glycobiology. 2004, 14(9), 793-804.
  22. Oda Y, Senaha T, Matsuno Y, Nakajima K, Naka R, Kinoshita M, Honda E, Kakehi K.
    A new fungal lectin recognizing α(1-6)-linked fucose in the N-glycan.
    J. Biol. Chem. 2004, 278(34), 32439-47.
  23. Nakajima K, Oda Y, Kinoshita M, Kakehi K.
    Capillary affinity electrophoresis for the screening of post-translational modification of proteins with carbohydrates.
    J. Proteome Res. 2003, 2, 81-8.
  24. Nakajima K, Oda Y, Kinoshita M, Masuko T, Kakehi K.
    Time-resolved fluorometric analysis of carbohydrates labeled with amino-aromatic compounds by reductive amination.
    Analyst. 2002, 127(7), 972-6.

Review and text books

総説

  1. Ohyama Y, Nakajima K, Renfrow MB, Novak J, Takahashi K.
    Mass spectrometry for the identification and analysis of highly complex glycosylation of therapeutic or pathogenic proteins
    Expert Rev Proteomics. 2020, 17(4), 275-96.
  2. 長塚康子, 中嶋和紀, 平林義雄.
    新しい脳脂質─ホスファチジルグルコシドとそのリゾ体脂質の生物機能.
    生体の科学, 2016, 67(3), 227-31.
  3. 秋山央子, 中嶋和紀, 平林義雄.
    糖脂質の新機能―多様な脂質のグルコース修飾機構と意義
    生化学, 2014, 86(6), 735-43.
  4. Angata T, Fujinawa R, Kurimoto A, Nakajima K, Kato M, Takamatsu S, Korekane H, Gao CX, Ohtsubo K, Kitazume S, Taniguchi N.
    Integrated approach toward the discovery of glyco-biomarkers of inflammation-related diseases.
    Ann. N Y Acad. Sci. 2012, 1253, 159-69.
  5. Shirato K, Nakajima K, Korekane H, Takamatsu S, Angata T, Ohtsubo K, Taniguchi N.
    Hypoxic regulation of glycoylation via the N-acetylglucosamine cycle.
    J. Clin. Biochem. Nutr. 2011, 48, 20-25.

著書

  1. 村上怜子,中嶋和紀, 糖ペプチドマップを利用した迅速グライコプロテオミクス解析,
    BIO Clinica,リキッドバイオプシー, 2024.
  2. 半澤健, がん細胞を標的としたムチナーゼの設計,
    3. Trends in Glycoscience and Glycotechnology (Glyco Topic), 36 (211), J60-J60, 2024.
  3. 村上怜子,中嶋和紀, 糖ペプチドマップベースの迅速グライコプロテオミクス基盤,
    4. Medical Science Digest, 最先端の今, 49, 13, 716-718,2024.
  4. 村上怜子, 人工甘味料エリスリトールの過剰摂取と心疾患リスクの相関関係の解析,
    ファルマシア, トピックス, 59, 11, 1041, 2023.
  5. 中嶋和紀, 嚢胞性腎疾患群における糖代謝を介する糖鎖シグナルの意義,
    腎臓病学, 名古屋大学出版会, 2023, 18, 1, 64-70.
  6. Nakajima K, Taniguchi N.
    Simultaneous determination of intracellular nucleotide sugars,
    Glycoscience Protocols (GlycoPODv2), Japan Consortium for Glycobiology and Glycotechnology; 2021,
    2021, [updated 2022].
  7. 中嶋和紀, 微量糖脂質の構造解析（コラム４）,
    糖鎖生物学 生命現象と糖鎖情報, 名古屋大学出版会, 2020, 55-8.
  8. Nakajima K, Takahashi K, Yamaguchi Y, Shinohara Y, Kaji H, Furukawa J, Suzuki A, Haga Y, Ueda K, Suda Y, Hirabayashi Y, Furukawa K, Yamamoto K, Kawasaki T, Honke K.
    Glycoscience: Basic Science to Applications (分担執筆：LC-MS), JCGG, 2020.
  9. 中嶋和紀, UDP-グルコースを介するSNAI1mRNAの分解調節はがん転移を抑制する,
    ファルマシア（トピックス）, 公益社団法人 日本薬学会, 2020.
  10. 中嶋和紀, 湯澤由紀夫, メタボロームと腎臓病,
    腎臓病学・泌尿器学, 2019, 9,1, 43-51.
  11. 中嶋和紀, マンノースは腫瘍増殖を抑制して化学療法の治療効果を高める,
    Trends in Glycoscience and Glycotechnology (Glyco Topic), 2019.
  12. 中嶋和紀, ヘキソサミン経路とN-acetylglucosaminyltransferaseによる代謝リプログラミング, Trends in Glycoscience and Glycotechnology (Glyco Topic), 2018.
  13. Nakajima K, Taniguchi, N.
    Simultaneous quantification of nucleotide sugar metabolism by LC and LC-MS. Glycoscience & Biology and Medicine, 2014, 103-10.
  14. Nakajima K, Koyama-Koganeya K, Hirabayashi Y.
    Profiling of glucosylceramides by LC-MS. Glycoscience & Biology and Medicine, 2014, 562-70.
  15. 中嶋和紀, キャピラリー電気泳動, The lung Perspective, 2008, 16(3).