岐阜大学 生命の鎖統合研究センター(G-CHAIN)|応用生物科学部|大学院自然科学技術研究科|糖鎖生化学研究室(木塚研究室)

研究業績

原著論文
総説論文

原著論文

2018年

  • *Nagae M., *Kizuka Y., Mihara E., Kitago Y., Hanashima S., Ito Y., Takagi J., Taniguchi N., Yamaguchi Y. (2018) Structure and mechanism of cancer-associated N-acetylglucosaminyltransferase-V (GnT-V). Nat. Commun., 9, 3380. *equal contribution
  • Imamaki R., Ogawa K., Kizuka Y., Komi Y., Kojima S., Kotani N., Honke K., Honda T., Taniguchi N., Kitazume S. (2018) Glycosylation controls cooperative PECAM-VEGFR2-β3 integrin functions at the endothelial surface for tumor angiogenesis. Oncogene, 37, 4287-4299.
  • Ota F., Hirayama T., *Kizuka Y., Yamaguchi Y., Fujinawa R., Nagata M., Ismanto HS., Yamasaki S., Lepenies B., Aretz J., Rademacher C., Seeberger PH., Angata T., Kitazume S., Yoshida K., Betsuyaku T., Kida K., Taniguchi N. (2018) High affinity sugar ligands of C-type lectin receptor langerin. Biochim. Biophys. Acta, 1862, 1592-1601. *corresponding author
  • Nakajima K., Kizuka Y., Yamaguchi Y., Hirabayashi Y., Takahashi K., Yuzawa Y., Taniguchi N. (2018) Identification and characterization of UDP-mannose in human cell lines and mouse organs: differential distribution across brain regions and organs. Biochem. Biophys. Res. Commun., 495, 401-407.

2017年

  • †Ota F., †*Kizuka Y., Nakano M., Yamaguchi Y., Kitazume S., Ookawara T., Taniguchi N. (2017) Sialylation of extracellular superoxide dismutase (EC-SOD) enhances furin-mediated cleavage and secretion. Glycobiology, 27, 1081-1088. †equal contribution, *corresponding author
  • Kizuka Y., Nakano M., Yamaguchi Y., Nakajima K., Oka R., Sato K., Hsu TL., Wong CH. Taniguchi N. (2017) An Alkynyl-fucose Halts Hepatoma Cell Migration and Invasion by Inhibiting GDP-Fucose Synthesizing Enzyme FX (TSTA3) Cell Chem. Biol., 24, 1467-1478.
  • Iijima J., Kobayashi S., Kitazume S., Kizuka Y., Fujinawa R., Korekane H., Shibata T., Saitoh S., Akashi-Takamura S., Miyake K., Miyoshi E., Taniguchi N. (2017) Core fucose is critical for CD14-dependent Toll-like receptor 4 signaling. Glycobiology, 27, 1006-1015.
  • Taichi M., Nomura S., Nakase I., Imamaki R., Kizuka Y., Ota F., Dohmae N., Kitazume S., Taniguchi N., Tanaka K. (2017) In-situ ligation of high- and low-affinity ligands to cell surface receptors enables highly selective recognition. Adv. Sci., 4, 1700147.
  • Sakuda K., Kizuka Y., Yamaguchi Y., Tanaka K., Ogiwara K., Segawa T., Hagiwara Y., Matsuo I., Ogawa H., Taniguchi N., Kitazume S. (2017) Reactivity of anti-HNK-1 antibodies to branched O-mannose glycans associated with demyelination. Biochem. Biophys. Res. Commun. 487, 450-456.
  • Kaburagi T., Kizuka Y., Kitazume S., Taniguchi N. (2017) Inhibitory Role of α2,6-Sialylation in Adipogenesis. J. Biol. Chem., 292, 2278-2286.
  • Gao C., Fujinawa R., Yoshida T., Ueno M, Ota F, Kizuka Y., Hirayama T., Korekane H., Kitazume S., Maeno T., Ohtsubo K., Yoshida K., Yamaguchi Y., Lepenies B., Aretz J., Rademacher C., Kabata H., Hegab AE., Seeberger PH., Betsuyaku T., Kida K., Taniguchi N. (2017) A keratan sulfate disaccharide prevents inflammation and the progression of emphysema in murine models. Am. J. Physiol. Lung Cell. Mol. Physiol., 312, L268-L276.

2016年

  • Ota F., Kizuka Y., Kitazume S., Adachi T., Taniguchi N. (2016) N-Glycosylation is essential for secretion of extracellular superoxide dismutase. FEBS Letters, 590, 3357-3367.
  • Kizuka Y., Funayama S., Shogomori H., Nakano M., Nakajima K., Oka R., Kitazume S., Yamaguchi Y., Sano M., Korekane H., Hsu TL., Lee HY., Wong CH., Taniguchi N. (2016). High sensitivity and low toxicity fucose probe for glycan imaging and biomarker discovery. Cell Chem. Biol., 23, 782-792.
  • Kizuka Y., Nakano M., Miura Y., Taniguchi N. (2016) Epigenetic regulation of neural N-glycomics. Proteomics, 16, 2854-2863.
  • Nagae M., Kanagawa M., Morita-Matsumoto K., Hanashima S., Kizuka Y., Taniguchi N., Yamaguchi Y. (2016) Atomic visualization of a flipped-back conformation of bisected glycans bound to specific lectins. Sci. Rep., 6, 22973.
  • Ogura A., Tahara T., Nozaki S., Morimoto K., Kizuka Y., Kitazume S., Hara M., Kojima S., Onoe H., Kurbangalieva A., Taniguchi N., Watanabe Y., Tanaka K. (2016) Visualizing Trimming Dependence of Biodistribution and Kinetics with Homo- and Heterogeneous N-Glycoclusters on Fluorescent Albumin. Sci. Rep., 6, 21797.
  • Kizuka Y., Nakano M., Kitazume S., Saito T., Saido T. C., Taniguchi N. (2016) Bisecting GlcNAc modification stabilizes BACE1 protein under oxidative stress conditions. Biochem. J., 473, 21-30.

2015年

  • Yabuno K., Morise J., Kizuka Y., Hashii N., Kawasaki N., Takahashi S., Miyata S., Izumikawa T., Kitagawa H., Takematsu H., Oka S. (2015) A sulfated glycosaminoglycan linkage region is a novel type of Human Natural Killer-1 (HNK-1) epitope expressed on aggrecan in perineuronal nets. PLos One, 10, e0144560.
  • Ito E., Oka R., Ishii T., Korekane H., Kurimoto A., Kizuka Y., Kitazume S., Ariki S., Takahashi M., Kuroki Y., Kida K., Taniguchi N. (2015) Fucosylated surfactant protein-D is a biomarker candidate for the development of chronic obstructive pulmonary disease. J. Proteomics, 127, 386-394.
  • Kizuka Y., Kitazume S., Sato K., Taniguchi N. (2015) Clec4g (LSECtin) interacts with BACE1 and suppresses Ab generation. FEBS Letters, 589, 1418-1422.
  • Kizuka Y., Kitazume S., Fujinawa R., Saito T., Iwata N., Saido T.C., Nakano M., Yamaguchi Y., Hashimoto Y., Staufenbiel M., Hatsuta H., Murayama S., Manya H., Endo T., Taniguchi N. (2015) An aberrant sugar modification of BACE1 blocks its lysosomal targeting in Alzheimer’s disease. EMBO Mol. Med., 7, 175-189.

2014年

  • Okahara K., Kizuka Y., Kitazume S., Ota F., Nakajima K., Hirabayashi Y., Maekawa M., Yoshikawa T., Taniguchi N. (2014) Ceramide galactosyltransferase expression is regulated positively by Nkx2.2 and negatively by OLIG2. Glycobiology, 24, 926-934.
  • Akasaka-Manya K., Manya H., Kizuka Y., Oka S., Endo T. (2014) a-Klotho mice demonstrate increased expression of the non-sulfated N-glycan form of the HNK-1 glyco-epitope in kidney tissue. J. Biochem., 156, 107-113.
  • Kizuka Y., Kitazume S., Okahara K., Villagra A., Sotomayor E.M., Taniguchi N. (2014) Epigenetic regulation of a brain-specific glycosyltransferase N-acetylglucosaminyltransferase-IX (GnT-IX) by specific chromatin modifiers. J. Biol. Chem., 289, 11253-11261.
  • Kurimoto A., Kitazume S., Kizuka Y., Nakajima K., Oka R., Fujinawa R., Korekane H., Yamaguchi Y., Wada Y., Taniguchi N. (2014) The absence of core fucose up-regulates GnT-III and Wnt target genes: a possible mechanism for an adaptive response in terms of glycan function. J. Biol. Chem., 289, 11704-11714.
  • Morise J., Kizuka Y., Yabuno K., Tonoyama Y., Hashii N., Kawasaki N., Manya H., Miyagoe-Suzuki Y., Takeda S., Endo T., Maeda N., Takematsu H., Oka S. (2014) Structural and biochemical characterization of O-mannose-linked human natural killer-1 glycan expressed on phosphacan in developing mouse brains. Glycobiology, 24, 314-324.

2013年以前

  • Kanekiyo K., Inamori K., Kitazume S., Sato K., Maeda J., Higuchi M., Kizuka Y., Korekane H., Matsuo I., Honke K., and Taniguchi N. (2013) Loss of branched O-mannosyl glycans in astrocytes accelerates remyelination. J. Neurosci., 33, 10037-10047.
  • Kouno T., Kizuka Y., Nakagawa N., Yoshihara T., Asano M., Oka S. (2011) Specific enzyme complex of beta-1,4-galactosyltransferase-II and glucuronyltransferase-P facilitates biosynthesis of N-linked human natural killer-1 (HNK-1) carbohydrate. J. Biol. Chem., 286, 31337-31346.
  • Kizuka Y., Kitazume S., Yoshida M., Taniguchi N. (2011) Brain-specific expression of N-acetylglucosaminyltransferase IX (GnT-IX) is regulated by epigenetic histone modifications. J. Biol. Chem., 286, 31875-31884.
  • Kizuka Y., Tonoyama Y., and Oka S. (2009) Distinct transport and intracellular activities of two GlcAT-P isoforms. J. Biol. Chem., 284, 9247-9256.
  • Morita I., Kakuda S., Takeuchi Y., Itoh S., Kawasaki N., Kizuka Y., Kawasaki T., Oka S. (2009) HNK-1 glyco-epitope regulates the stability of the glutamate receptor subunit GluR2 on the neuronal cell surface. J. Biol. Chem., 284, 30209-30217.
  • Yoshihara T., Sugihara K., Kizuka Y., Oka S., Asano M. (2009) Learning/memory impairment and reduced expression of the HNK-1 carbohydrate in beta4-galactosyltransferase-II-deficient mice. J. Biol. Chem., 284, 12550-12561.
  • Kizuka Y., Kobayashi K., Kakuda S., Nakajima Y., Itoh S., Kawasaki N., Oka S. (2008) Laminin-1 is a novel carrier glycoprotein for the nonsulfated HNK-1 epitope in mouse kidney. Glycobiology, 18, 331-338.
  • Inoue M., Kato K., Matsuhashi H., Kizuka Y., Kawasaki T., Oka S. (2007) Distributions of glucuronyltransferases, GlcAT-P and GlcAT-S, and their target substrate, the HNK-1 carbohydrate epitope in the adult mouse brain with or without a targeted deletion of the GlcAT-P gene. Brain Res., 1179, 1-15.
  • Kizuka Y., Matsui T., Takematsu H., Kozutsumi Y., Kawasaki T., Oka S. (2006) Physical and functional association of glucuronyltransferases and sulfotransferase involved in HNK-1. J. Biol. Chem., 281, 13644-13651.
  • Tagawa H., Kizuka Y., Ikeda T., Itoh S., Kawasaki N., Kurihara H., Onozato ML, Tojo A., Sakai T., Kawasaki T., Oka S. (2005) A non-sulfated form of the HNK-1 carbohydrate is expressed in mouse kidney. J. Biol. Chem., 280, 23876-23883.

総説論文

  • *Kizuka Y. (2018) Detection and modulation of fucosylated glycans using fucose analogs. Trends Glycosci. Glycotech., in press, *corresponding author
  • *Kizuka Y., Mishra S., Yamaguchi Y., Taniguchi N. (2018) Implication of C-type lectin receptor langerin and keratan sulfate disaccharide in emphysema. Cell. Immunol., in press, *corresponding author
  • *Kizuka Y., Taniguchi N. (2018) Neural functions of bisecting GlcNAc. Glycoconj. J., *corresponding author
  • *Kizuka Y., Kitazume S., Taniguchi N. (2017) N-glycan and Alzheimer’s disease. Biochim. Biophys. Acta, 1861, 2447-2454. *corresponding author
  • *Kizuka Y. (2017) Expression of neural glycans and their role in disease. Trends Glycosci. Glycotech., 29, E11-E18. *corresponding author
  • Taniguchi N., Takahashi M., Kizuka Y., Kitazume S., Ookawara T., Furuta A. (2016) Glycation vs. Glycosylation: a tale of two different chemistries and biology in Alzheimer’s disease. Glycoconj. J., 33, 487-497.
  • Takahashi M., Kizuka Y., Ohtsubo K., Gu J., Taniguchi N. (2016) Disease-associated glycans on cell surface proteins. Mol. Aspects of Med., 51, 56-70.
  • Kizuka Y., Taniguchi N. (2016) Enzymes for N-Glycan Branching and Their Genetic and Nongenetic Regulation in Cancer. Biomolecules, 6, E25
  • Taniguchi N., Kizuka Y., Takamatsu S., Miyoshi E., Gao CX., Suzuki K., Kitazume S., Ohtsubo K. (2015) Glyco-redox, a link between oxidative stress and changes of glycans: Lessons from research on glutathione, reactive oxygen and nitrogen species to glycobiology. Arch. Biochem. Biophys., 595, 72-80.
  • Taniguchi N., Kizuka Y. (2015) Glycans and Cancer: Role of N-glycans in cancer biomarker, progression and metastasis and therapeutics. Adv. Cancer. Res., 126, 11-51.
  • Kizuka Y., Kanekiyo K., Kitazume S., Taniguchi N. (2014) Use of Glycan-Targeted Antibodies/Lectins to Study the Expression/Function of Glycosyltransferases in the Nervous System. Adv. Neurobiol., 9, 117-127.
  • Kizuka Y., and Oka S. (2012) Regulated expression and neural functions of human natural killer-1 (HNK-1) carbohydrate. Cell. Mol. Life Sci., 69, 4135-4147.
  • Kizuka Y., Oka S. (2010) Regulation of HNK-1 (Human Natural Killer-1) carbohydrate expression: Multiple control mechanisms of biosynthetic enzyme activity. Trends Glycosci. Glycotech., 22, 194-199.
  • Morita I., Kizuka Y., Kakuda S., Oka S. (2008) Expression and function of the HNK-1 carbohydrate. J. Biochem., 143, 719-724.