Member
Gifu University iGCORE
Integrated Glyco-Molecular Science Center (iGMOL)
Specially-Appointed Assistant Professor
Kenjiroo Matsumoto
Education
| 2007 |
Senshu University Matsudo High school |
| 2011 |
Tokyo University of Science, Bachelor of basic engineering |
| 2013 |
Tokyo University of Science, Master of basic engineering (supervised by Dr. Kenji Matsuno) |
| 2016 |
Osaka University, Ph.D., Sciences (Genetics) (supervised by Dr. Kenji Matsuno) |
Positions and Trainings
| 2016-2021 |
Junior-Postdoc, Complex Carbohydrate Research Center, University of Georgia (Mentor: Dr. Robert Haltiwanger) |
| 2021-2023 |
Senior-Postdoc, Complex Carbohydrate Research Center, University of Georgia (Mentor: Dr. Robert Haltiwanger) |
| 2023- |
Current Position |
Awards
| 2010 |
Poster Award, 28th Naito Conference |
| 2015 |
Presentation Award, The 8th National Tsing University-Osaka University Life Science Symposium
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| 2017 |
Travel Award, The Society for Glycobiology, U.S. |
| 2018 |
Travel Award, The Society for Glycobiology, U.S. |
| 2019 |
Travel Award, The Society for Glycobiology, U.S. |
Publication
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*Ayukawa T.,* Matsumoto K., Ishikawa H. O., Ishio A., Yamakawa T., Aoyama N., Suzuki T., and Matsuno K. (2012) Rescue of Notch signaling in cells incapable of GDP-L-fucose synthesis by gap junction transfer of GDP-L-fucose in Drosophila. Proc. Natl. Acad. Sci. U. S. A., 109, 15318-23. *equal contribution
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Nakamura M., Matsumoto K., Iwamoto Y., Muguruma T., Nakazawa N., Hatori R., Taniguchi K., Maeda R., Matsuno K. (2013) Reduced cell number in the hindgut epithelium disrupts hindgut left–right asymmetry in a mutant of pebble, encoding a RhoGEF, in Drosophila embryos. Mech. Dev, 130, 169–180.
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*Matsumoto K., Ishio A., Matsuno K. (2014) O-Fucose Glycan in Drosophila Notch Signaling. Glycoscience: Biology and Medicine ,( Tanigushi N., Endo T., Hart G., Seeberger P., Wong C. H., eds) Springer, 841-847. *corresponding author
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Ishio A., Sasamura T., Ayukawa T., Kuroda J., Ishikawa H.O., Aoyama N.,
Matsumoto K., Gushiken T., Okajima T., Yamakawa T., and Matsuno K. (2015)
O-fucose monosaccharide of Drosophila Notch has a temperature-sensitive function and cooperates with O-glucose glycan in Notch transport and Notch signaling activation. J. Biol. Chem.,290, 505-19.
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Matsumoto K., Ayukawa T., Ishio A., Sasamura T., Yamakawa T., and Matsuno K. (2016) Dual roles of O-glucose glycans redundant with monosaccharide O-fucose on Notch in Notch trafficking. J. Biol. Chem., 291, 13743-52
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*Matsumoto K., Haltiwanger R. S. (2018) “What are the Real Functions of O-Glycan Modifications of Notch?” Trends glycosci. Glycotechnol., 30(175): p. E129-E136. *corresponding author
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Matsumoto K.*, Luther K. B., and Haltiwanger R. S.(2020) Diseases related to Notch glycosylation. Mol. Aspects Med., 79, 100938
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Sosicka P., Ng B. G., Pepi L.E., Shajahan A., Wong M. Y., Scott D. A.,
Matsumoto K., Xia J., Lebrilla C. B., Haltiwanger R. S., Azadi P., Freeze H. H. (2021) Metabolic heritage mapping: heterogenous pools of cytoplasmic nucleotide sugars are selectively utilized by various glycosyltransferases. J. Cell. Biol., 221
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Matsumoto K., Kumar V., Varshney V., Nairn A. V., Ito A., Pennarubia F., Moremen K. W., Stanley P., Haltiwanger R. S. (2022) Fringe GlcNAc-transferases differentially extend O-fucose on endogenous NOTCH1 in mouse activated T cells.
J. Biol. Chem., 298, 102064.
Message
The time that we can use for research activity is surprisingly short. Therefore, it is crucial to discern the essence of things and focus. I believe that one of the fundamental aspects of glycan modification is the constant variation in living organisms. I aspire to... 1: develop methodologies for observing changes in glycan modifications, 2: identify factors contributing to structural alterations of glycans, and 3: explore compounds that can induce the alternation of glycan modifications.
