教授あいさつ 研究紹介

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  研究業績


 2014
  • Shima T, Shiina T, Naitou K, Nakamori H, Shimizu Y
    Functional roles of capsaicin-sensitive intrinsic neural circuit in the regulation of esophageal peristalsis in rats: in vivo studies using a novel method.
    Am. J. Physiol. Gastrointest. Liver Physiol. in press


 2013
  • Shiina T., Koga M., Saito S., Atoji Y., Takewaki T., Shimizu Y.
    Development of longitudinal smooth muscle in the posterior mesenteric artery and purinergic regulation of its contractile responses in chickens.
    J. Comp. Physiol. A 34 (4): 173-178, 2013.


  • Iwami M., Alkayed F., Shiina,T., Taira K., Shimizu Y.
    Activation of brown adipose tissue thermogenesis by electrical stimulation to the dorsal surface of the tissue in rats.
    Biomed. Res.
    34: 173-178, 2013.


  • Shiina T., Gurung Y.B., Suzuki Y., Takewaki T., Shimizu Y.
    Alteration of neuromuscular transmissions in the hamster colon following the resolution of TNBS-induced colitis.
    J. Physiol. Sci. 63: 241-249, 2013.


  • Shiina T., Shima T., Suzuki Y., Shimizu Y.
    Inhibitory actions of a local neural reflex on propulsive activity of the esophageal striated muscle portion in rats
    Res. Vet. Sci. 94: 331-335, 2013.


  • Roy TK, Iwasawa A, Shimizu Y, Kageyama K, Yoshizaki N.
    Ontogenic profile of hexokinase and glucokinase mRNA expressions in embryonic chicken liver and muscle.
    J. Poult. Sci. 50 (3): 270-274, 2013


  • Roy TK, Iwasawa A, Shimizu Y, Kageyama K, Yoshizaki N.
    Ontogenic profile of gluconeogenic key enzyme gene expressions in embryonic chicken liver and muscle.
    J. Poult. Sci. 50 (4): 381-387, 2013


  • 志水泰武
    消化器ならびに胃拡張・胃捻転症候群の手術時に知っておくべき生理学
    J-Vet 26(4):8-15, 2013


  • 志水泰武
    麻酔にかかることとは? 睡眠、冬眠との類似点と相違点を考察する
    J-Vet 26(11):8-14, 2013


  • 平山晴子、樅木勝巳、椎名貴彦、志水泰武
    脊髄を介するグレリンの大腸運動促進作用
    岡山実験動物研究会報 29:51-54, 2013


  • 平山晴子、樅木勝巳、椎名貴彦、志水泰武
    ラットにおけるグレリンの大腸運動調節作用
    九州実験動物雑誌 29:3-7, 2013



 2012
  • Shiina T., Shima T., Suzuki Y., Worl, J., Shimizu Y.
    Neural regulation of esophageal striated muscle in the house musk shrew (Suncus murinus).
    Auton. Neurosci. 168: 25-31, 2012.


  • Nakamori C., Shiina T., Shimizu Y.
    Postnatal changes in vagal control of esophageal muscle contractions in rats.
    Life Sci. 90: 495-501, 2012.


  • Shiina T., Shimizu, Y.
    Neural regulatory mechanisms of esophageal motility and its implication for GERD.
    In Gastroesophageal Reflux Disease (ISBN: 978-953-51-0314-1) Bortolotti , M., ed. InTech. 3-20, 2012.


  • 志水泰武
    消化管運動の基本と嘔吐・下痢が起こるメカニズム
    CAP (Companion Animal Practice) 27(2):8-21, 2012


  • 志水泰武
    免疫のメカニズム
    J-Vet 25(10):8-18, 2012




このページの先頭へ戻る

 2011
  • Alkayed F., Shiina T, Takewaki T., Shimizu Y.
    Postnatal development of excitatory innervations in longitudinal smooth muscle of the chicken anterior mesenteric artery.
    Life Sci. 88: 400-405, 2011


  • Iwami M., Mahmoud F.A., Shiina,T., Hirayama H., Shima T., Sugita J., Shimizu Y.
    Extract of grains of paradise and its active principle 6-paradol trigger thermogenesis of brown adipose tissue in rats.
    Auton. Neurosci.
    161: 63-67, 2011.


  • Abe C., Iwata C., Shiina T., Shimizu Y., Morita H.
    Effect of daily linear acceleration training on the hypergravity-induced vomiting response in house musk shrew (Suncus murinus).
    Neurosci Lett. 502:138-142, 2011


  • Iwami M., Shiina T., Hirayama H., Shima T., Takewaki T., Shimizu Y.
    Inhibitory effects of zingerone, a pungent component of Zingiber officinale Roscoe, on colonic motility in rats.
    J. Nat. Med. 65: 89-94, 2011


  • Iwami M., Shiina T., Hirayama H., Shimizu Y.
    Intraluminal administration of zingerol, a non-pungent analogue of zingerone, inhibits colonic motility in rats.
    Biomed. Res. 32: 181-185, 2011


  • 志水泰武
    体温調節と発熱のメカニズム
    CAP (Companion Animal Practice) 26(1):8-20, 2011


  • 志水泰武、平山晴子、嶋 剛士、椎名貴彦
    グレリンによる排便促進機構
    自律神経 48(2):86-88, 2011


  • 椎名貴彦志水泰武
    嘔吐する小型実験動物スンクスの食道における内在神経性制御
    日本病態生理学会雑誌 20(3):21-23, 2011



このページの先頭へ戻る

 2010
  • Hirayama H., Shiina T., Shima T., Kuramoto H., Takewaki T., Furness J.B., Shimizu Y.
    Contrasting effects of ghrelin and des-acyl ghrelin on the lumbo-sacral defecation center and regulation of colorectal motility in rats.
    Neurogastroenterol. Motil. 22: 1124-1131, 2010


  • Shiina T., Shima T., Masuda K., Hirayama H., Iwami M., Takewaki T., Kuramoto H., Shimizu Y.
    Contractile properties of esophageal striated muscle: comparison with cardiac and skeletal muscles in rats.
    J. Biomed. Biotech. vol. 2010, Article ID 459789, 7 pages, 2010


  • Mahmoud M.E., Nikami H., Shiina T., Takewaki T., Shimizu Y.
    Capsaicin inhibits IFN-gamma-induced MHC class II expression by suppressing transcription of class II transactivator gene in murine peritoneal macrophages.
    Int. Immunopharmacol. 10:86-90, 2010


  • Shiina T., Shima T., Hirayama H., Kuramoto H., Takewaki T., Shimizu Y.
    Contractile responses induced by physalaemin, an analogue of substance P, in the rat esophagus.
    Eur. J. Pharmacol. 628: 202-206, 2010


  • Shiina T., Shima T., Worl J., Neuhuber W.L., Shimizu Y.
    The neural regulation of the mammalian esophageal motility and its implication for esophageal diseases. (Review)
    Pathophysiology 17:129-133, 2010


  • Ferens D.M., Yin L., Bron R., Hunne B., Ohashi-Doi K., Kitchener P.D., Sanger G.J., Witherington J., Shimizu Y., Furness,J.B.
    Functional and in situ hybridisation evidence that preganglionic sympathetic vasoconstrictor neurons express ghrelin receptors.
    Neuroscience 166:671-679, 2010


  • 平山晴子, 椎名貴彦, 嶋 剛士, 石見百江, 志水泰武.
    グレリンによる大腸運動促進機構(総説).
    日本病態生理学会雑誌 19: 28-33, 2010.


  • 志水泰武
    黄疸の病態生理
    CLINIC NOTE 56:8-13, 2010


  • 志水泰武
    症例から学ぶ基礎病態生理「胃の通過障害と消化器疾患に関する生理学的アプローチ」
    CLINIC NOTE 63:77-88, 2010


  • 志水泰武、北川均
    肥 満
    SA Medicine 69:44-45, 2010

このページの先頭へ戻る

 2009
  • Alkayed, F., Boudaka, A., Shiina T, Takewaki, T., Shimizu, Y.
    P2X purinoceptors mediate an endothelium-dependent hyperpolarization in longitudinal smooth muscle of anterior mesenteric artery in young chickens.
    Br. J. Phramacol. 158:888-895, 2009


  • Boudaka A, Worl J, Shiina T, Shimizu Y, Takewaki T., Neuhuber WL
    Galanin modulates vagally induced contractions in the mouse esophagus.
    Neurogastroenterol. Motil. 21:180-188, 2009


  • Shafton, A.D., Sanger, G.J., Witherington, J., Brown, J.D., Muir, A., Butler, S., Abberley, L., Shimizu, Y., Furness, J.B.
    Oral administration of a centrally-acting ghrelin receptor agonist to conscious rats triggers defecation.
    Neurogastroenterol. Motil. 21: 71-77, 2009


  • Miyazawa, S., Shiina, T., Takewaki, T., Shimizu, Y.
    Extension of time until cardiac arrest after injection of a lethal dose of pentobarbital in the hibernating Syrian hamster.
    J. Vet. Med. Sci. 71:383-385, 2009


  • Seddek, A.l.S., Mahmoud, M.E., Shiina, T., Hirayama, H., Iwami, M., Miyazawa, S., Nikami, H., Takewaki, T., Shimizu, Y.
    Activation of murine macrophages by the extract from Calotropis procera latex.
    J. Nat. Med. 63:297-303, 2009


  • Hempfling C, Seibold R, Shiina T, Heimler W, Neuhuber WL, Woerl J.
    Enteric co-innervation of esophageal striated muscle fibers: A phylogenetic study.
    Auton. Neurosci.. 151: 135-141, 2009


  • 志水泰武, 宮澤誠司, 椎名貴彦, 武脇 義.
    低体温によって惹起される障害を回避するメカニズム ー 冬眠動物をモデルとした解析 ー(総説).
    日本病態生理学会雑誌 18: 46-49, 2009.


  • 志水泰武
    ニューロキニン受容体(総説).
    生体の科学 特集号:伝達物質と受容体 60: 476-477, 2009.


      このページの先頭へ戻る

       2008
      • Shimizu, Y., Matsuyama, H., Shiina, T., Takewaki, T. and Furness, J.B.
        Tachykinins and their functions in the gastrointestinal tract (review).
        Cell. Mol. Life Sci. 65: 295-311, 2008


      • Miyazawa, S., Shimizu, Y., Shiina, T., Hirayama, H., Morita, H., Takewaki, T.
        Central A1-receptor activation associated with onset of torpor protects the heart against low temperature in the Syrian hamster.
        Am. J. Physiol. 295: R991-996, 2008


      • Nikami, H., Mahmoud, M.E., Shimizu, Y., Shiina, T., Hirayama, H., Iwami, M., Dosoky, R.M., Ahmed, M.M., Takewaki, T.
        Capsaicin pretreatment attenuates LPS-induced hypothermia through TRPV1-independent mechanisms in chicken.
        Life Sci. 82: 1191-1195, 2008


      • Shinozaki, K., Shimizu, Y., Shiina, T., Morita, H. and Takewaki, T.
        Relationship between taste-induced physiological reflexes and temperature of sweet taste.
        Physiol. Behav. 93:1000-1004, 2008


      • Furness, J.B., Nguyen, T.V., Nurgali, K., Shimizu, Y.
        Chapter 2: The enteric nervous system and its extrinsic connections.
        In Textbook of Gastroenterology 5th edition Yamada, T., Alpers, D., Owyang, C., Powell, D.W., Silverstein, F. eds. JB Lippincott, Philadelphia. 15-39, 2008.


      • 宮澤誠司, 椎名貴彦, 志水泰武.
        冬眠時の心拍動を維持するメカニズム(総説).
        獣医生化学 45: 1-6, 2008.

         

        このページの先頭へ戻る

         2007
        • Shafton AD, Bogeski G, Kitchener P, Sanger GJ, Furness JB, Shimizu Y.
          Effects of NMDA receptor antagonists on visceromotor reflexes and on intestinal motility, in vivo.
          Neurogastroenterol. Motil. 19: 617-624, 2007


        • Boudaka A, Worl J, Shiina T, Neuhuber WL, Kobayashi H, Shimizu Y, Takewaki T.
          Involvement of TRPV1-dependent and -independent components in the regulation of vagally induced contractions in the mouse esophagus.
          Eur J Pharmacol. 556 :157-165, 2007


        • Mahmoud, M.E., Shimizu, Y., Shiina, T., Nikami, H., Dosoky, R.M., Ahmed, M.M., Takewaki, T.
          Involvement of a capsaicin-sensitive TRPV1-independent mechanism in lipopolysaccharide-induced fever in chickens.
          Comp. Biochem. Physiol. 148: 578-583, 2007


        • Gurung, Y.B., Shimizu, Y., Shiina, T., Mahmoud, M.E., Saito, S. and Takewaki, T.
          Impairment and restoration of spontaneous contractile activity of longitudinal smooth muscles in the TNBS-inflamed hamster distal colon.
          Biomed. Res. 28: 301-308, 2007


        • Borghan MA, Mori Y, El-Mahmoudy AB, Ito N, Sugiyama M, Takewaki T, Minamoto N.
          Induction of nitric oxide synthase by rotavirus enterotoxin NSP4: implication for rotavirus pathogenicity.
          J. Gen. Virol. 88: 2064-2072, 2007


        • Tonosaki, K., Hori, Y., Shimizu, Y., Tonosaki, K.
          Relationship between insulin release and taste.
          Biomed. Res. 28: 79-83, 2007


        • Boudaka A, Worl J, Shiina T, Saito S, Atoji Y, Kobayashi H, Shimizu Y, Takewaki T.
          Key role of mucosal primary afferents in mediating the inhibitory influence of capsaicin on vagally mediated contractions in the mouse esophagus.
          J Vet Med Sci. 69: 365-372, 2007


        • Shiina T, El-Mahmoudy A, Khalifa M, Draid M, Shimizu Y, Takewaki T.
          Purinergic control of the quail rectum: Modulation of adenosine 5
          '-triphosphate-mediated contraction with acetylcholine
          Res. Vet. Sci. 82:246-251, 2007


        • Shiina, T., Shimizu, Y., Boudaka, A., Worl, J., Neuhuber, W.L., Takewaki, T.
          Local neural regulation of the motility of the striated muscle portion in the mammalian esophagus.
          In Current Topics in Pharmacology Vol. 11 (1), 11-17, Richard, R. ed. Research Trends Ltd, Trivandrum, 2007.


        • 椎名貴彦、宮澤誠司、Marwan Draid、志水泰武、武脇 義.
          哺乳動物の冬眠行動に影響する環境条件(総説).
          日本野生動物医学会誌 12: 35-39, 2007.


        • 武脇 義.
          循環調節 ー血管抵抗物語ー.
          日本生理学会誌 69: 292-296, 2007.


           

          このページの先頭へ戻る

           2006
          • Shimizu Y, Chang EC, Shafton AD, Ferens D, Sanger GJ, Witherington J, Furness JB.
            Evidence that stimulation of ghrelin receptors in the spinal cord initiates propulsive activity in the colon of the rat.
            J Physiol. 576: 329-338, 2006


          • Shiina T, Shimizu Y, Boudaka A, Worl J, Takewaki T.
            Tachykinins are involved in local reflex modulation of vagally mediated striated muscle contractions in the rat esophagus via tachykinin NK1 receptors.
            Neuroscience 139: 495-503, 2006


          • El-Mahmoudy A, Khalifa M, Draid M, Shiina T, Shimizu Y, El-Sayed M, Takewaki T.
            NANC inhibitory neuromuscular transmission in the hamster distal colon.
            Pharmacol. Res. 54:452-560, 2006


          • Thompson-Vest N, Shimizu Y, Hunne B, Furness JB.
            The distribution of intermediate-conductance, calcium-activated, potassium (IK) channels in epithelial cells.
            J. Anat. 2: 219-229, 2006


          • Mubarak Hossain M, Suzuki T, Sato N, Sato I, Takewaki T, Suzuki K, Tachikawa E, Kobayashi H.
            Differential effects of pyrethroid insecticides on extracellular dopamine in the striatum of freely moving rats.
            Toxicol Appl Pharmacol. 217:25-34, 2006


          • Lang RJ, Nguyen DT, Matsuyama H, Takewaki T, Exintaris B.
            Characterization of spontaneous depolarizations in smooth muscle cells of the Guinea pig prostate.
            J. Urol. 175: 370-80, 2006


          • 志水泰武、斉藤昌之
            脱共役蛋白質(UCP)ファミリー
            インスリン抵抗性 (松澤佑次、藤田敏郎、門脇 孝 編集)医学書院、pp229-235, 2006.



          このページの先頭へ戻る

           2005
          • Draid M, Shiina T, El-Mahmoudy A, Boudaka A, Shimizu Y, Takewaki T.
            Neurally released ATP mediates endothelium-dependent hyperpolarization in the circular smooth muscle cells of chicken anterior mesenteric artery.
            Br. J. Pharmacol. 146: 983-989, 2005.


          • Khalifa M, El-Mahmoudy A, Shiina T, Shimizu Y, Nikami H, El-Sayed M, Kobayashi H, Takewaki T.
            An electrophysiological study of excitatory purinergic neuromuscular transmission in longitudinal smooth muscle of chicken anterior mesenteric artery .
            Br. J. Pharmacol. 144: 830-839, 2005.


          • Shiina T, Shimizu Y, Suzuki Y, Nikami H, Takewaki T.
            Measurement of the propelled liquid by isolated hamster ileum as a parameter to evaluate peristalsis.
            Eur. J. Pharmacol. 517:120-126, 2005.


          • Shinozaki K, Shimizu Y, Shiina T, Nishijima K, Atoji Y, Nikami H, Niijima A, Takewaki T.
            A neurophysiological evidence of capsaicin-sensitive nerve components innervating interscapular brown adipose tissue.
            Auton. Neurosci. 119:16-24, 2005.


          • El-Mahmoudy A, Shimizu Y, Shiina T, Matsuyama H, El-Sayed M, Takewaki T.
            Successful abrogation by thymoquinone against induction of diabetes mellitus with streptozotocin via nitric oxide inhibitory mechanism.
            Int. Immunopharmacol. 5: 195-207, 2005.


          • El-Mahmoudy A, Shimizu Y, Shiina T, Nikami H, Matsuyama H, Takewaki T.
            Macrophage-derived cytokine and nitric oxide profiles in typeI and typeII diabetes mellitus: effect of thymoquinone.
            Acta Diabetologica 42: 23-30, 2005.


          • Fararh KM, Shimizu Y, Shiina T, Nikami H, Ghanem MM, Takewaki T.
            Thymoquinone reduces hepatic glucose production in diabetic hamsters.
            Res. Vet. Sci. 79: 219-223, 2005.


          • Shiina T, Shimizu Y, Izumi N, Suzuki Y, Asano M, Atoji Y, Nikami H, Takewaki T.
            A comparative histological study on the distribution of striated and smooth muscles and glands in the esophagus of wild birds and mammals.
            J. Vet. Med. Sci. 67: 115-117, 2005.


          • Saitoh M, Ishii T, Takewaki T, Nishimura M.
            Preference for Safflower Oil in Rats Exposed to a Cold Environment under Free-Feeding Conditions.
            J. Vet. Med. Sci. 67: 653-658, 2005.


          • Okishio Y, Takeuchi T, Fujita A, Suenaga K, Fujinami K, Munakata S, Takewaki T, Hata F.
            Ascending contraction and descending relaxation in the distal colon of mice lacking interstitial cells of Cajal.
            J. Smooth Muscle Res. 41:163-174, 2005.


          • Hossain MM, Suzuki T, Sato I, Takewaki T, Suzuki K, Kobayashi H.
            Neuromechanical effects of pyrethroids, allethrin, cyhalothrin and deltamethrin on the cholinergic processes in rat brain.
            Life Sci. 77:795-807, 2005.


          • Waseda K, Takeuchi T, Ohta M, Okishio Y, Fujita A, Hata F, Takewaki T.
            Participation of ATP in nonadrenergic, noncholinergic relaxation of longitudinal muscle of wistar rat jejunum.
            J. Pharmacol. Sci. 97:91-100, 2005.


          • El-Mahomoudy, A., Shimizu, Y., Takewaki, T.
            Neuroeffector mechanisms of the non-adrenergic, non-cholinergic inhibitory transmission in the large intestine.
            Recent Research Developments in Physiology Pandalai, S.G. ed., Research Signport, Kerala, pp. 1-12, 2005.


          • 上田直光、大城健、岡田拓也、紫藤哲生、志水泰武、外崎肇一
            甘味刺激に対する内分泌応答
            日本味と匂学会誌 12: 445-448, 2005.


          • 志水泰武
            クエン酸回路と酸化的リン酸化.
            獣医生化学(斉藤昌之, 鈴木嘉彦, 横田博 編)朝倉書店, pp.84-92, 2005.


          • 志水泰武
            脂質の代謝.
            獣医生化学(斉藤昌之, 鈴木嘉彦, 横田博 編)朝倉書店, pp.93-103, 2005.


            このページの先頭へ戻る

             2004
            • Fararh KM, Atoji Y, Shimizu Y, Shiina T, Nikami H, Takewaki T.
              Mechanism of hypoglycaemic and immunopotentiating effect of Nigella sativa L oil in streptozotocin-induced diabetic hamster.
              Res. Vet. Sci. 77:123-129, 2004.


            • Fujita A, Okishio Y, Fujinami K, Nakagawa M, Takeuchi T, Takewaki T, Hata F.
              Role of the interstitial cells distributed in the myenteric plexus in neural reflexes in the mouse ileum.
              J. Pharmacol. Sci. 96: 483-92, 2004.


            • Takeuchi T, Yamazaki Y, Negoro T, Fujinami K, Mukai K, Fujita A, Takewaki T, Hata F.
              Changes in mechanism of PACAP-induced relaxation in longitudinal muscle of the distal colon of Wistar rats with age.
              Regul. Pept. 118: 1-9, 2004.


            • Takeuchi T, Fujinami K,Fujita A, Okishio Y, Takewaki T, Hata F.
              Essential role of the interstitial cells of cajal in nitric oxide-mediated relaxation of longitudinal muscle of the mouse ileum.
              J. Pharmacol. Sci. 95:71-80, 2004.


            • Hossain MM, Suzuki T, Sato I, Takewaki T, Suzuki K, Kobayashi H.
              The modulatory effect of pyrethroids on acetylcholie release in the hippocampus of freely moving rats.
              NeuroToxicology 25:825-833, 2004.


            • Shiina T, Konno A, Oonuma T, Kitamura H, Imaoka K, Takeda N, Todokoro K, Morimatsu M.
              Targeted disruption of MAIL, a nuclear IkB protein, leads to severe atopic dermatitis-like disease.
              J. Biol. Chem. 279: 55493-55498, 2004.


            • Ito T, Morimatsu M, Oonuma T, Shiina T, Kitamura H, Syuto B.
              Transcriptional regulation of the MAIL gene in LPS stimulated RAW264 mouse macrophages.
              Gene 342:137-143, 2004.


            • Yamaji D, Kitamura H, Kimura K, Matsushita Y, Okada H, Shiina T, Morimatsu M, Saito M.
              Cloning of bovine MAIL and its mRNA expression in white blood cells of Holstein cows.
              Vet. Immunol. Immunopathol. 98:175-184. 2004.


            • 志水泰武椎名貴彦、アブバクル・エルマフモウディ、二上英樹、武脇 義
              天然植物由来活性物質・サイモキノンの薬理作用発現機序(総説)
              獣医生化学 41:15-21, 2004



            このページの先頭へ戻る

             2003
            • El-Mahmoudy A, Matsuyama H, Khalifa M, Shimizu Y, Takewaki T.
              Tachykinins mediate non-adrenergic, non-cholinergic excitatory neurotransmission to the hamster ileum via NK1 and NK2 receptors.
              Life Sci. 73: 1939-1951, 2003.


            • Izumi N, Matsuyama H, Ko M, Shimizu Y, Takewaki T.
              Role of intrinsic nitrergic neurones on vagally-mediated striated muscle contractions in the hamster oesophagus.
              J. Physiol. 531: 287-294, 2003.


            • Shimizu Y, Yamazaki M, Nakanishi K, Sakurai M, Sanada A, Takewaki T, Tonosaki K.
              Enhanced responses of the chorda tympani nerve to sugars in the ventromedial hypothalamic obese rat.
              J. Neurophysiol. 90:128-133, 2003.


            • Matsuyama H, El-Mahmoudy A, Shimizu Y, Takewaki T.
              Nitrergic prejunctional inhibition of purinergic neuromuscular transmission in the hamster proximal colon.
              J. Neurophysiol. 89:2346-2353, 2003.


            • Thapaliya S, Matsuyama H, El-Mahmoudy A, Shimizu Y, Takewaki T.
              An endothelium-derived factor modulates purinergic neurotransmission to mesenteric arterial smooth muscle of hamster.
              Eur. J. Pharmacol. 461:129-137, 2003


            • 志水泰武、嶋津孝
              交感神経によって促進されるグルコース輸送系:骨格筋および褐色脂肪の培養細胞を用いたメカニズムの検討(総説)
              獣畜新報 56: 28-32, 2003.


            • 堀泰典、松谷晃子、志水泰武、杉田憲司、外崎肇一
              インシュリン分泌と味覚
              日本味と匂学会誌 10: 475-478, 2003.


            このページの先頭へ戻る

             2002
            • Saito H, Thapaliya S, Matsuyama H, Nishimura M, Unno T, Komori S, Takewaki T.
              Reversible impairment of endothelium-dependent relaxation in golden hamster carotid arteries during hibernation.
              J. Physiol. 540:285-594, 2002.


            • Izumi N, Matsuyama H, Yamamoto Y, Atoji Y, Suzuki Y, Unno T, Takewaki T.
              Morphological and morphometrical characteristics of the esophageal intrinsic nervous system in the golden hamster.
              Eur. J. Morphol. 40:137-144. 2002.


            • Matsuyama H, Unno T, El-Mahmoudy AM, Komori S, Kobayashi H, Thapaliya S, Takewaki T.
              Peptidergic and nitrergic inhibitory neurotransmissions in the hamster jejunum: regulation of vasoactive intestinal peptide release by nitric oxide.
              Neuroscience 110:779-788, 2002.


            • Yamaji M, Ohta M, Yamazaki Y, Fujinami K, Fujita A, Takeuchi T, Hata F, Takewaki T.
              A possible role of neurotensin in NANC relaxation of longitudinal muscle of the jejunum and ileum of Wistar rats.
              Br. J. Pharmacol. 137:629-636, 2002.


            • Morita H, Sharada T, Takewaki T, Ito Y, Inoue R.
              Multiple regulation by external ATP of nifedipine-insensitive, high voltage-activated Ca(2+) current in guinea-pig mesenteric terminal arteriole.
              J. Physiol. 539:805-816, 2002.


            • El-Mahmoudy A, Matsuyama H, Borgan MA, Shimizu Y, El-Sayed MG, Minamoto N, Takewaki T.
              Thymoquinone suppresses expression of inducible nitric oxide synthase in rat macrophages.
              Int. Immunopharmacol. 2:1603-1611, 2002.


            • Fararh KM, Atoji Y, Shimizu Y, Takewaki T.
              Isulinotropic properties of Nigella sativa oil in Streptozotocin plus Nicotinamide diabetic hamster.
              Res. Vet. Sci. 73:279-282,.2002.


            • Shimizu Y, Shimazu T.
              Thyroid hormone augments GLUT4 expression and insulin-sensitive glucose transport system in differentiating rat brown adipocytes in culture.
              J. Vet. Med. Sci. 64:677-681, 2002.


            • Kitamura H, Kanehira K, Shiina T, Morimatsu M, Jung BD, Akashi S, Saito M.
              Bacterial lipopolysaccharide induces mRNA expression of an IkappaB MAIL through toll-like receptor 4.
              J. Vet. Med. Sci. 64:419-422, 2002.


            • 武脇 義、斉藤英毅、志水泰武
              冬眠哺乳動物の末梢循環調節機構 -血管交感神経と内皮細胞の機能変化-
              野生動物医学会誌 7:61-68, 2002

              

              


            このページの先頭へ戻る

             2001
            • Saito H, Thapaliya S, Matsuyama H, Nishimura M, Takewaki T.
              Enhancement of ATP release in hindlimb sympathetic perivascular nerve of the golden hamster during hibernation.
              J. Physiol. 531:495-507, 2001.


            • Kamata R, Saito S, Suzuki T, Takewaki T, Kobayashi H.
              Correlation of binding sites for diisopropyl phosphorofluoridate with cholinesterase and neuropathy target esterase in membrane and cytosol preparations from hen.
              NeuroToxicology 22 :203-314, 2001.


            • Kamata R, Saito SY, Suzuki T, Takewaki T, Kofujita H, Ota M, Kobayashi H.
              A comparative study of binding sites for diisopropyl phosphorofluoridate in membrane and cytosol preparations from spinal cord and brain of hens.
              NeuroToxicology 22:191-202, 2001.


            • Shiina T, Morimatsu M, Kitamura H, Ito T, Kidou S, Matsubara K, Matsuda Y, Saito M, Syuto B.
              Genomic organization, chromosomal localization, and promoter analysis of the mouse Mail gene.
              Immunogenetics 53:649-655, 2001.


            • 志水泰武、山崎美史、櫻井 牧、外崎肇一
              視床下部性肥満ラットの味覚変化と糖質嗜好性
              肥満研究 7:79-82, 2001


            • 志水泰武、櫻井牧、外崎肇一
              ラットの多糖類に対する味覚神経応答
              日本味と匂学会誌 8:641-644, 2001


            • 平野好幸、志水泰武、外崎肇一
              脳波測定法によるイヌの嗅覚機能測定法について
              日本味と匂学会誌 8, 601-604, 2001


            このページの先頭へ戻る

             2000
            • Thapaliya S, Matsuyama H, Takewaki T.
              Bradykinin causes endothelium-independent hyperpolarisation and neuromodulation by prostanoid synthesis in hamster mesenteric artery.
              Eur. J. Pharmacol. 408:313-321, 2000.


            • Unno T, Inaba T, Ohashi H, Takewaki T, Komori S.
              Role of Ca2+ mobilization in muscarinic receptor-mediated membrane depolarization in guinea pig ileal smooth muscle cells.
              Jpn. J. Pharmacol. 84:431-437, 2000


            • Takeuchi T, Negoro T, Yamaji M, Yamazaki Y, Fujita A, Nishio H, Takewaki T, Takatsuji K, Hata F.
              Increase in participation of vasoactive intestinal peptide in relaxation of the distal colon of Wistar rats with age.
              Br. J. Pharmacol. 131:942-948, 2000.


            • Kishi M, Takeuchi T, Katayama H, Yamazaki Y, Nishio H, Hata F, Takewaki T.
              Involvement of cyclic AMP - PKA pathway in VIP-induced, charybdotoxin-sensitive relaxation of longitudinal muscle of the distal colon of Wistar-ST rats.
              Br. J. Pharmacol. 129:140-146, 2000.


            • Ogiso K, Shimizu Y, Watanabe K, Tonosaki K.
              Possible involvement of undissociated acid molecules in the acid response of the chorda tympani nerve of the rat.
              J. Neurophysiol. 83:2776-2779, 2000.


            • Nakayasu C, Kanemura F, Hirano Y, Shimizu Y, Tonosaki K.
              Sensitivity of the olfactory sense declines with the aging in senescence-accelerated mouse (SAM-P1).
              Physiol. Behav. 70:135-139, 2000.


            • Sakurai N, Kanemura F, Watanabe K, Shimizu Y, Tonosaki K.
              Effects of acids on neural activity elicited by other taste stimuli in the rat Chorda tympani.
              Brain Res. 859:369-372, 2000.


            • 志水泰武、外崎肇一
              適切な摂食行動をもたらすための味覚変化
              獣医畜産新報 53:329-330, 2000


            • 北川均、溝口仁美、鬼頭克也、桑原康人、大場恵典、志水泰武、大塚喜彦、佐々木栄英
              肥満犬における血漿レプチン濃度
              日本小動物獣医学会誌 53:311-314, 2000 



            このページの先頭へ戻る

             1999
            • Thapaliya S, Matsuyama H, Takewaki T.
              ATP released from perivascular nerves hyperpolarizes smooth muscle cells by releasing an endothelium-derived factor in hamster mesenteric arteries.
              J. Physiol. 521:191-199, 1999.


            • Matsuyama H, Thapaliya S, Takewaki T.
              Cyclic GMP-associated apamin-sensitive nitrergic slow inhibitory junction potential in the hamster ileum.
              Br. J. Pharmacol. 128:830-836, 1999



            • Takeuchi T, Kishi M, Hirayama N, Yamaji M, Ishii T, Nishio H, Hata F, Takewaki T.
              Tyrosine kinase involvement in apamin-sensitive inhibitory responses of rat distal colon.
              J. Physiol. 514 :177-188. 1999



            • Shimizu Y, Tonosaki K.
              Low environmental temperature modulates gustatory nerve activity and behavioral responses to NaCl in rats.
              Am. J. Physiol. 277:R368-R373, 1999.


            • 志水泰武、山崎美史、櫻井牧、中西啓司、外崎肇一
              視床下部性肥満ラットのデンプン嗜好性と味覚応答性
              日本味と匂学会誌 6:613-616, 1999


            • 小木曽和麿、志水泰武、外崎肇一
              ラット鼓索神経の非イオン化酸分子に対する応答
              日本味と匂学会誌 6:567-570, 1999


            • 平野好幸、志水泰武、外崎肇一
              脳波高周波成分の嗅覚刺激に対する応答
              日本味と匂学会誌 6:361-364, 1999



            このページの先頭へ戻る

             1998
            • Takeuchi T, Niioka S, Kishi M, Ishii T, Nishio H, Hata F, Takewaki T, Takatsuji K.
              Nonadrenergic, noncholinergic relaxation mediated by nitric oxide with concomitant change in Ca2+ level in rectal circular muscle of rats.
              Eur. J. Pharmacol. 353:67-74, 1998


            • Shimizu Y, Satoh S, Yano H, Minokoshi Y, Cushman SW, Shimazu T.
              Effects of noradrenaline on the cell-surface glucose transporters in cultured brown adipocytes: novel mechanism for selective activation of GLUT1 glucose transporter.
              Biochem. J. 330:397-403, 1998


            • Ota M, Shimizu Y, Tonosaki K, Ariyoshi Y.
              Role of hydrophobic amino acids in gurmarin, a sweetness-suppressing polypeptide.
              Biopolymers 45:231-238, 1998


            • Ota M, Shimizu Y, Tonosaki K, Ariyoshi Y.
              Synthesis, characterization, and sweetness-suppressing activities of gurmarin analogues missing one disulfide bond.
              Biopolymers 46: 65-73, 1998


            • 志水泰武、金村福寿、外崎肇一
              寒冷曝露に伴うラット鼓索神経の NaCl応答増大のメカニズム
              日本味と匂学会誌
              5:461-464, 1998


            • 渡辺研、志水泰武、金村福寿、外崎肇一
              ラットの各種酸溶液に対する味覚神経応答と忌避行動
              日本味と匂学会誌 5:457-460, 1998

                  

            このページの先頭へ戻る

             1997
            • Niioka S, Takeuchi T, Kishi M, Ishii T, Nishio H, Takewaki T, Hata F.
              Nonadrenergic, noncholinergic relaxation in longitudinal muscle of rat jejunum.
              Jpn. J. Pharmacol. 73:155-161, 1997.


            • Shimizu Y, Tanishita T, Minokoshi Y, Shimazu T.
              Activation of mitogen-activated protein kinase by norepinephrine in brown adipocytes from rats.
              Endocrinology 138:248-253, 1997


            • Tanishita T, Shimizu Y, Minokoshi Y, Shimazu T.
              The
              β3-adrenergic agonist BRL37344 increases glucose transport into L6 myocytes through a mechanism different from that of insulin.
              J. Biochem. 122:90-95, 1997


            • 志水泰武、外崎肇一
              寒冷環境下でのラット鼓索神経の味応答
              日本味と匂学会誌 4:405-408, 1997



            • 渡辺研、志水泰武、外崎肇一
              ラット酸応答と水素イオン濃度の関係
              日本味と匂学会誌 4:429-432, 1997



            • 谷下彰見、志水泰武、箕越靖彦、嶋津孝
              骨格筋細胞へのグルコース輸送を促進するβ3アドレナリン作動薬の作用
              肥満研究 3:119-124, 1997



             

             1996
            • Kishi M, Takeuchi T, Suthamnatpong N, Ishii T, Nishio H, Hata F, Takewaki T.
              VIP- and PACAP-mediated nonadrenergic, noncholinergic inhibition in longitudinal muscle of rat distal colon: involvement of activation of charybdotoxin- and apamin-sensitive K+ channels.
              Br. J. Pharmacol. 119:623-630, 1996


            • Shimizu Y, Kielar D, Minokoshi Y, Shimazu T.
              Noradrenaline increases glucose transport into brown adipocytes in culture by a mechanism different from that of insulin.
              Biochem. J. 314:485-490, 1996


            • Nikami H, Shimizu Y, Sumida M, Minokoshi Y, Yoshida T, Saito M, Shimazu T.
              Expression of
              β3-adrenoceptor and stimulation of glucose transport by β3-agonist in brown adipocyte primary culture.
              J. Biochem. 119:120-125, 1996


            • Fukuzumi M, Shinomiya H, Shimizu Y, Ohishi K, Utsumi S.
              Endotoxin-induced enhancement of glucose influx into murine macrophages via GLUT1.
              Infect. Immun. 108:108-112, 1996


            • Minokoshi Y, Shimizu Y, Shimazu T.
              Hypothalamic and sympathetic nervous regulation of glucose uptake in certain peripheral tissues.
              Liver Innervation (Shimazu, T. Ed.) John Libbey & Company Ltd., London, 227-236, 1996


            • 谷下彰見、志水泰武、箕越靖彦、嶋津 孝
              βアドレナリン作動薬による骨格筋細胞へのグルコース輸送促進作用とそのメカニズムの解析
              肥満学会記録誌 16: 257-258,1996.


            • 櫻井紀夫、志水泰武、中安千洋、大野勝利、外崎肇一
              酸味によるラット鼓索神経の甘味応答の増強と塩味・苦味応答抑制
              日本味と匂学会誌 3:408-411, 1996


            • 大澤朋子、中山直美、志水泰武、大野勝利、外崎肇一
              ニオイ刺激に対するニワトリの脳波
              日本味と匂学会誌 3:510-513, 1996


            • 原映子、志水泰武、浜井盟子、嶋津孝
              高蔗糖食または高脂肪食の長期投与ラットに及ぼす分離大豆たん白質の効果
              大豆たん白質研究会会誌 17: 103-107,1996.



              このページの先頭へ戻る

               1995
              • Tsukazaki K, Nikami H, Shimizu Y, Kawada T, Yoshida T, Saito M.
                Chronic administration of
                β-adrenergic agonists can mimic the stimulative effect of cold exposure on protein synthesis in rat brown adipose tissue.
                J. Biochem. 117:96-100, 1995


              • Shimazu T, Shimizu Y, Minokoshi Y.
                Roles of the hypothalamus and sympathetic nerves in the regulation of thermogenesis and glucose transport in brown adipose tissue.
                Body Temperature and Metabolism (Nagasaka T. And Milton, A.S. Eds.) IPEC., Tokyo, pp179-182, 1995


              • 志水泰武、箕越靖彦、嶋津 孝
                初代培養褐色脂肪細胞におけるグルコース輸送とグルコーストランスポーターの発現
                肥満研究 1:20-24,1995



              • 志水泰武、嶋津 孝
                Brown adipocytesの初代培養法
                糖尿病研究のストラテジー (清野 進、岡 芳知 監修)秀潤社、東京、pp311-313,1995


              • 原 映子、志水泰武、嶋津 孝
                授乳期母仔ラットの脂質代謝に及ぼす高蔗糖・SPI食の影響
                大豆たん白質研究会会誌 16: 9-13,1995.



              このページの先頭へ戻る

               1994
              • Ohashi H, Takewaki T, Unno T, Komori S.
                Mechanical and current responses to neurotensin in the smooth muscle of guinea-pig intestine.
                J. Auton. Pharmacol. 14:239-251, 1994


              • Shimizu Y, Kielar D, Masuno H, Minokoshi Y, Shimazu T.
                Dexamethasone induces GLUT4 glucose transporter, and responses of glucose transport to norepinephrine and insulin in primary culture of brown adipocytes.
                J. Biochem. 115:1069-1074, 1994


              • Shimizu Y, Shimazu T.
                Effects of wortmannin on increased glucose transport by insulin and norepinephrine in primary culture of brown adipocytes.
                Biochem. Biophys. Res. Commun. 202:660-665, 1994


              • Machado UF, Shimizu Y, Saito M.
                Reduced content and preserved translocation of glucose transporter (GLUT4) in white adipose tissue of obese mice.
                Physiol. Behav. 55:621-625, 1994


              • 志水泰武、斉藤昌之
                褐色脂肪細胞における熱産生とグルコーストランスポーター
                生体の科学
                45:45-47,1994


              • 原 映子、志水泰武、嶋津 孝
                幼若ラットを用いた小児成人病モデルに対する大豆たん白質の効果
                大豆たん白質研究会会誌 15: 95-98,1994.


              • 斉藤昌之、二上英樹、浅野淳、長瀬逸郎、塚崎勝己、志水泰武
                褐色脂肪の遺伝子発現に対するカテコールアミンとβ作動薬の作用
                肥満学会記録誌 14: 148-149,1994.


              • 志水泰武、Kielar, D.、升野博志、 箕越靖彦、嶋津 孝
                培養褐色脂肪細胞におけるグルコース輸送とカテコールアミンの作用
                肥満学会記録誌 14: 150-151,1994.



              このページの先頭へ戻る

               1993
              • Shimizu, Y., Nikami, H., Tsukazaki, K., Machado, U. F., Yano, H., Seino, Y., Saito, M.
                Increased expression of glucose transporter GLUT-4 in brown adipose tissue of fasted rats after cold exposure.
                Am. J. Physiol. 264: E890-E895, 1993.


              • Machado, U. F., Shimizu, Y., Saito, M.
                Decreased glucose transporter (GLUT4) content in insulin-sensitive tissues of obese aurothioglucose- and monosodium glutamate-treated mice.
                Horm. Metab. Res. 25 : 462-465, 1993.


              • 斉藤昌之、志水泰武、二上英樹、塚崎勝己
                視床下部性肥満における褐色脂肪の代謝異常
                肥満学会記録誌 13: 61-63,1993.



              このページの先頭へ戻る

               1992
              • Nikami, H., Shimizu, Y., Endoh, D., Yano, H., Saito, M.
                Cold exposure increases glucose utilization and glucose transporter expression in brown adipose tissue.
                Biochem. Biophys. Res. Commun. 185: 1078-1082, 1992.


              • 志水泰武、斉藤昌之
                褐色脂肪組織の脱共役タンパク質と肥満(総説).
                Pharma Medica 10: 21-26, 1992.


              • Machado, U. F., Shimizu, Y., Saito, M.
                Reduction of insulin-sensitive glucose transporter in white adipose tissue of hypothalamic obese mice.
                肥満学会記録誌 12: 127-129,1992.



              このページの先頭へ戻る

               1991
              • Shimizu, Y., Saito, M.
                Activation of brown adipose tissue thermogenesis in recovery from anesthetic hypothermia in rats.
                Am. J. Physiol. 261: R301-R304, 1991.


              • Shimizu, Y., Nikami H., Saito, M.
                Sympathetic activation of glucose utilization in brown adipose tissue in rats.
                J. Biochem. 110: 688-692, 1991.


              • Saito, M., Akiyoshi M., Shimizu, Y.
                Possible role of the sympathetic nervous system in responses to interleukin-1.
                Brain Res. Bull. 27: 305-308, 1991.


              • Shimizu, Y., Suzuki, M.
                The relationship between red cell aging and enzyme activities in experimental animals.
                Comp. Biochem. Physiol. 99B: 313-316, 1991.


              • Shimizu, Y., Kawarada, S., Suzuki, M., Tanaka, T.
                Interstrain differences in red cell enzyme activities in mice and rats.
                Comp. Biochem. Physiol. 100B: 687-690, 1991.


              • Saito, M., Shimizu, Y., Minokoshi, Y., Shimazu, T.
                Hypothalamic and sympathetic nerve control of brown adipose tissue metabolism and thermogenesis.
                In "Progress in Obesity Research 1990 " Oomura, Y. et al. eds., John Libbey & Company Ltd., London, pp. 131-134, 1991.


              このページの先頭へ戻る

               1990
              • Akiyoshi, M., Shimizu, Y., Saito, M.
                Interleukin-1 increases norepinephrine turnover in the spleen and lung in rats.
                Biochem. Biophys. Res. Commun. 173: 1266-1270, 1990.