OKA LABORATORY

2010以前

25. Synthesis and biological activity of artificial mRNA prepared with novel phosphorylating reagents. Nagata, S.; Hamasaki, T.; Uetake, K.; Masuda, H.; Takagaki, K.; Oka, N.; Wada, T.; Ohgi, T.; Yano, J. Nucleic Acids Res. 2010, 38, 7845–7857.

24. Rapid glycosylations under extremely mild acidic conditions. Use of ammonium salts to activate glycosyl phosphites via P-protonation. Matsumura, F.; Tatsumi, S.; Oka, N.; Wada, T. Carbohydr. Res. 2010, 345, 1211–1215.

23. 1,2-trans-Selective synthesis of glycosyl boranophosphates and their utility as building blocks for the synthesis of phosphodiester-linked disaccharides. Sato, K.; Oka, N.; Fujita, S.; Matsumura, F.; Wada, T. J. Org. Chem. 2010, 75, 2147–2156.

22. Solid-phase synthesis of oligodeoxyribonucleotides without base protection utilizing O-selective reaction of oxazaphospholidine derivatives. Oka, N.; Maizuru, Y.; Shimizu, M.; Wada, T. Nucleosides Nucleotides Nucleic Acids 2010, 29, 144–154.

21. Stereocontrolled synthesis of tertiary silanes via optically pure 1,3,2-oxazasilolidine derivatives. Oka, N.; Nakamura, M.; Soeda, N.; Wada, T. J. Organomet. Chem. 2009, 694, 2171–2178.

20. Nucleoside H-boranophosphonates: a new class of boron-containing nucleotide analogues. Higashida, R.; Oka, N.; Kawanaka, T.; Wada, T. Chem. Commun. 2009, 2466–2468.

19. Stereocontrolled synthesis of oligoribonucleoside phosphorothioates by an oxazaphospholidine approach. Oka, N.; Kondo, T.; Fujiwara, S.; Maizuru, Y.; Wada, T. Org. Lett. 2009, 11, 967–970.

18. Stereocontrolled solid-phase synthesis of oligonucleoside H-phosphonates by an oxazaphospholidine approach. Iwamoto, N.; Oka, N.; Sato, T.; Wada, T. Angew. Chem. Int. Ed. 2009, 48, 496-499.

17. Solid-phase synthesis of stereoregular oligodeoxyribonucleoside phosphorothioates using bicyclic oxazaphospholidine derivatives as monomer units. Oka, N.; Yamamoto, M.; Sato, T.; Wada, T. J. Am. Chem. Soc. 2008, 130, 16031–16037.

16. Stereoselective synthesis of α-glycosyl phosphites and phosphoramidites via O-selective glycosylation of H-phosphonate derivatives. Matsumura, F.; Oka, N.; Wada, T. Org. Lett. 2008, 10, 5297–5300.

15. Chemical synthesis of diastereomeric diadenosine boranophosphate (ApbA) from 2'-O-(2-cyanoethoxymethyl)adenosine by the boranophosphotriester method. Enya, Y.; Nagata, S.; Masutomi, Y.; Kitagawa, H.; Takagaki, K.; Oka, N.; Wada, T.; Ohgi, T.; Yano, J. Bioorg. Med. Chem. 2008, 20, 9154–9160.

14. Synthesis of glycosyl boranophosphates and their applications as precursors of glycosyl phosphate analogues. Matsumura, F.; Oka, N.; Wada, T. Org. Lett. 2008, 10, 1557-1560.

13. Protein-based peptide-bond formation by aminoacyl-tRNA protein transferase. Watanabe, K.; Toh, Y.; Suto, K.; Shimizu, Y.; Oka, N.; Wada, T.; Tomita, K. Nature 2007, 449, 867–871.

12. Synthesis, DNA polymerase incorporation, and enzymatic phosphate hydrolysis of formamidopyrimidine nucleoside triphosphates. Imoto, S.; Patro, J. N.; Jiang, Y. L.; Oka, N.; Greenberg, M. M. J. Am. Chem. Soc. 2006, 128, 14606–14611.

11. Stereoselective synthesis of dinucleoside boranophosphates by an oxazaphospholidine method. Wada, T.; Maizuru, Y.; Shimizu, M.; Oka, N.; Saigo, K. Bioorg. Med. Chem. Lett. 2006, 16, 3111–3114.

10. 1,3-Dimethyl-2-(3-nitro-1,2,4-triazol-1-yl)-2-pyrrolidin-1-yl-1,3,2-diazaphospholidinium hexafluorophosphate: a powerful condensing reagent for phosphate and phosphonate esters. Oka, N.; Shimizu, M.; Saigo, K.; Wada, T. Tetrahedron 2006, 62, 3667–3673.

9. Highly chemo- and regioselective phosphitylation of unprotected 2'-deoxyribonucleosides. Kato, Y.; Oka, N.; Wada, T. Tetrahedron Lett. 2006, 47, 2501–2505.

8. The effect of the 2-amino group of 7,8-dihydro-8-oxo-2'-deoxyguanosine on translesion synthesis and duplex stability. Oka, N.; Greenberg, M. M. Nucleic Acids Res. 2005, 33, 1637–1643.

7. A novel method for the synthesis of dinucleoside boranophosphates by a borano-phospho-triester method. Shimizu, M.; Wada, T.; Oka, N.; Saigo, K. J. Org. Chem. 2004, 69, 5261–5268.

6. 3,3'-Oxybis(dimethoxytrityl chloride) (O-DMTCl): synthesis and applications of a novel bifunctional protecting group. Oka, N.; Sanghvi, Y. S.; Theodorakis, E. A. Bioorg. Med. Chem. Lett. 2004, 14, 3241–3244.

5. 1,2-Ethylene-3,3-bis(4',4''-dimethoxytrityl chloride) (E-DMT): synthesis and applications of a novel protecting reagent. Oka, N.; Sanghvi, Y. S.; Theodorakis, E. A. Synett 2004, 5, 823–826.

4. An oxazaphospholidine approach for the stereocontrolled synthesis of oligonucleoside phosphorothioates. Oka, N.; Wada, T.; Saigo, K. J. Am. Chem. Soc. 2003, 125, 8307–8317.

3. Diastereo-controlled synthesis of dinucleoside phosphorothioates using a novel class of activators, dialkyl(cyanomethyl)ammonium tetrafluoroborates. Oka, N.; Wada, T.; Saigo, K. J. Am. Chem. Soc. 2002, 124, 4962–4963.

2. A new boranophosphorylation reaction for the synthesis of deoxyribonucleoside boranophosphates. Wada, T.; Shimizu, M.; Oka, N.; Saigo, K. Tetrahedron Lett. 2002, 43, 4137–4140.

1. Application of cis-2-amino-3,3-dimethyl-1-indanol as an efficient chiral auxiliary to the asymmetric Ireland-Claisen rearrangement. Improvement of the diastereoselectivity by combinational use of chlorodimethylsilane as a silylating agent. Matsui, S.; Oka, N.; Hashimoto, Y.; Saigo, K. Enantiomer 2000, 5, 105–108.

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