OB & OG 2007
■ Visiting Researcher
| Mai EFDI (2004/10-) |
Isolation of secondary metabolites from Annonaceae plants and their biological activities |
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| Phytochemical analysis and antileukemic activity of polyphenolic constituents of Toona sinensis Akinori Kakumu, Masayuki Ninomiya, Mai Efdi, Morina Adfa, Masahiro Hayashi, Kaori Tanaka, Mamoru Koketsu Bioorganic Medicinal Chemistry Letters, 24(17), 4286-4290 (2014). |
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| Cerodane diterpenes isolated from Polyalthia longifolia induce apoptosis in human leukemia HL-60 Cells Dina Permata Sari, Masayuki Ninomiya, Mai Efdi, Adlis Santoni, Sanusi Ibrahim, Kaori Tanaka, Mamoru Koketsu Journal of Oleo Science, 62(10), 843-848 (2013). |
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| Sentulic acid: a cytotoxic ring A-seco triterpenoid from Sandoricum koetjape Merr M. Efdi, M. Ninomiya, E. Suryani, K. Tanaka, S. Ibrahim, K. Watanabe, M. Koketsu Bioorg. Med. Chem. Lett., 22, 4242-4245 (2012). |
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| Isolation of chemical constituents from Enicosanthum cupulare (King) Airy-Shaw S. Fujita, M. Ninomiya, M. Efdi, K. Ohguchi, Y. Nozawa, M. Koketsu Nat. Prod. Res., 24, 1630-1636 (2010). |
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| Chalcone glycosides from aerial parts of Brassica rapa L. ‘hidabeni’, turnip M. Ninomiya, M. Efdi, T. Inuzuka, M. Koketsu Phytochemistry Lett., 3, 96-99 (2010). |
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| Chemical studies on Goniothalamus tapis Miq M. Efdi, S. Fujita, T. Inuzuka, M. Koketsu Nat. Prod. Res., 24, 657-662 (2010). |
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| N-trans-Feruloyltyramine as melanin biosynthesis inhibitor M. Efdi, K. Ohguchi, Y. Akao, Y. Nozawa, M. Koketsu, H. Ishihara Biol. Pharm. Bull., 30, 1972-1974 (2007). |
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| The isolation of secondary metabolites and in vitro potent anti-cancer activity of clerodermic acid from Enicosanthum membranifolium M. Efdi, T. Itoh, Y. Akao, Y. Nozawa, M. Koketsu, H. Ishihara Bioorg. Med. Chem., 15, 3667-3671 (2007). |
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| (R)-(-)-8-Hydroxy-3-methyl-3,4-dihydro-1H-2-benzopyran-1-one M. Efdi, M. Koketsu, M. Ebihara, H. Ishihara Acta Cryst., E62, o2133-o2134 (2006). |
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| 2-(3-Hydroxy-4-methoxyphenyl)-N,N,N-trimethylethanaminium chloride M. Efdi, M. Koketsu, M. Ebihara, H. Ishihara Acta Cryst., E62, o2993-o2994 (2006). |
■ MASTER
| Takashi KIYOKUNI (2005/4-) |
Study of stereoselective sialylation reaction by C1-auxiliary group |
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| Synthesis of 1,3-selenazines and 1,3-selenazolidines via intramolecular addition of N-allylselenoureas M. Koketsu, T. Kiyokuni, T. Sakai, H. Ando, H. Ishihara Chem. Lett., 35, 626-627 (2006). |
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| One-pot synthesis of 2-imino-1,3-selenazolidines by reaction of isoselenocyanates with propargylamine M. Koketsu, T. Sakai, T. Kiyokuni, D. R. Garud, H. Ando, H. Ishihara Heterocycles, 68, 1607-1615 (2006). |
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| Masayuki NINOMIYA (2005/4-) |
Study for total utilization of bamboo grass (Kumazasa) -Isolation and synthesis of major component- |
| Suppression of EC-SOD by oxLDL During Vascular Smooth Muscle Cell Proliferation Junya Makino, Rei Asai, Mao Hashimoto, Tetsuro Kamiya, Hirokazu Hara, Masayuki Ninomiya, Mamoru Koketsu, Tetsuo Adachi Journal of Cellular Biochemistry, 117, 2496-2505 (2016). |
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| Flavonoid profile and antileukemic activity of Coreopsis lanceolata flowers Antoni Pardede, Koharu Mashita, Masayuki Ninomiya, Kaori Tanaka, Mamoru Koketsu Bioorganic & Medicinal Chemistry Letters, 26(12), 2784-2787 (2016). |
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| Antileukemic activity of lignans and phenylpropanoids of Cinnamomum parthenoxylon Morina Adfa, Rizki Rahmad, Masayuki Ninomiya, Salprima Yudha S., Kaori Tanaka, Mamoru Koketsu Bioorganic & Medicinal Chemistry Letters, 26(3), 761-764 (2016). |
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| Effects of various 5,7-dihydroxyflavone analogs on adipogenesis in 3T3-L1 cells Atsuyoshi Nishina, Motohiko Ukiya, Makoto Fukatsu, Mamoru Koketsu, Masayuki Ninomiya, Daisuke Sato, Junpei Yamamoto, Kazuo Kobayashi-Hattori, Takeshi Okubo, Hirokazu Kimura Biological Pharmceutical Bulletin, 38(11), 1794-1800 (2015). |
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| Synthesis, characterization, and antileukemic properties of naphthoquinone derivatives from lawsone Ryuta Inagaki, Masayuki Ninomiya, Kaori Tanaka, Mamoru Koketsu ChemMedChem, 10(8), 1413-1423 (2015). |
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| Dioscin derived from Solanum melongena L. “Usukawamarunasu” attenuates a-MSH–induced melanogenesis in B16 murine melanoma cells via downregulation of phospho-CREB and MITF Atsuyoshi Nishina, Kodai Ebina, Motohiko Ukiya, Makoto Fukatsu, Mamoru Koketsu, Masayuki Ninomiya, Daisuke Sato, Hirokazu Kimura Journal of Food Science, 80(10), H2354-H2359 (2015). |
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| Termiticidal activity of Acorus calamus Linn. rhizomes and its main constituents against Coptotermes curvignathus Holmgren Morina Adfa, Fio Livandri, Neva Putri Meita, Syalfinaf Manaf, Masayuki Ninomiya, Ifran Gustian, Agus Martono Hadi Putranto, Rochmah Supriati, Mamoru Koketsu Journal of Asia-Pacific Entomology, 18, 47-50 (2015). |
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| Synthesis of triazole- and tetrazole-xyloside analogues as potent hyaluronidase inhibitors Yuki Kato, Masayuki Ninomiya, Yuji Yamaguchi, Mamoru Koketsu Medicinal Chemistry Research, 24, 1180-1188 (2015). |
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| A synthesized nostocionone derivative potentiates programmed cell death in human T-cell leukemia Jurkat cells through mitochondria with the release of Endonuclease G Tomohiro Itoh, Yuji Muramatsu, Masayo Masu, Ayaka Tsuge, Masaki Taniguchi, Masayuki Ninomiya，Masashi Ando, Yasuyuki Tsukamasa, Mamoru Koketsu Nutrition and Cancer, 66(8), 1414-1423 (2014). |
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| Phytochemical analysis and antileukemic activity of polyphenolic constituents of Toona sinensis Akinori Kakumu, Masayuki Ninomiya, Mai Efdi, Morina Adfa, Masahiro Hayashi, Kaori Tanaka and Mamoru Koketsu Bioorganic Medicinal Chemistry Letters, 24(17), 4286-4290 (2014). |
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| The Staudinger reaction with 2-imino-1,3-thiaselenanes toward the synthesis of C4 spiro-b-lactams Y. Toyoda, M. Ninomiya, M. Ebihara, M. Koketsu Organic & Biomolecular Chemistry, 11(16), 2652-2659 (2013). |
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| Minor Flavonoids (Chalcones, Flavanones, Dihydrochalcones, and Aurones) M. Ninomiya, M. Koketsu in Natural Products: Phytochemistry, Botany and Metabolism of Alkaloides, Phenolics and Terpenes, K. G. Ramawat, J. -M. Merillon Eds., Springer, Heidelberg, Germany, 2013, Chapter 61, p. 1867-1900. |
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| Newly synthesized 'hidabeni' chalcone derivatives potently suppress LPS-induced NO production via inhibition of STAT1, but not NF-κB, JNK, and p38, pathways in microglia Hirokazu Hara, Ryoko Ikeda, Masayuki Ninomiya, Tetsuro Kamiya, Mamoru Koketsu, Tetsuo Adachi Biological and Pharmaceutical Bulletin, 37(6), 1042-1049 (2014). |
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| Comparison of antitermite properties of 2-thioxocoumarins against Coptotermes formosanus Shiraki Masayuki Ninomiya, Tatsuyuki Aoki, Morina Adfa, Tsuyoshi Yoshimura, Mamoru Koketsu Holzforschung, 68(3), 361-365 (2014). |
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| Antimicrobial and anti-inflammatory properties of nostocionone isolated from Nostoc commune Vauch and its derivatives against Propionibacterium acnes Tomohiro Itoh, Akihiro Tsuchida, Yuji Muramatsu, Masayuki Ninomiya, Tsukamasa, Mamoru Koketsu Anaerobe, 27, 56-63 (2014). |
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| Neurite outgrowth of PC12 cells by 4'-O-β-D-glucopyranosyl-3',4-dimethoxychalcone from Brassica rapa L. 'hidabeni' was enhanced by pretreatment with p38MAPK Atsuyoshi Nishina, Hirokazu Kimura, Hiroyuki Tsukagoshi, Kunihisa Kozawa, Mamoru Koketsu, Masayuki Ninomiya, Daisuke Sato, Yutaro Obara, Shoei Furukawa Neurochemical Research, 38(11), 2397-2407 (2013). |
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| Effects of 2,2-dimethylchromenes against feeding behavior of Coptotermes formosanus Shiraki Yusuke Hiramatsu, Morina Adfa, Masayuki Ninomiya, Tsuyoshi Yoshimura, Mamoru Koketsu Journal of Pesticide Science, 38(4), 228-231 (2013). |
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| Synthesis and cytotoxicity on human leukemia cells of furonaphthoquinones isolated from Tabebuia plants R. Inagaki, M. Ninomiya, K. Tanaka, K. Watanabe, M. Koketsu Chemical Pharmceutical Bulletin, 61(6), 670-673 (2013). |
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| Luteolin suppresses the differentiation of THP-1 cells through the inhibition of NOX2 mRNA expression and the membrane translocation of p47phox J. Makino, R. Nakanishi, T. Kamiya, H. Hara, M. Ninomiya, M. Koketsu, T. Adachi Journal of Natural Products, 76(7), 1285-1290 (2013). |
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| Reduced scytonemin isolated from Nostoc commune induces autophagic cell death in human T-lymphoid cell line Jurkat cells Tomohiro Itoh, Ryosuke Tsuzuki, Toshiomi Tanka, Masayuki Ninomiya, Yuji Yamaguchi, Hiroyuki Takenaka, Masashi Ando, Yasuyuki Tsukamasa, Mamoru Koketsu Food and Chemical Toxicology, 60, 76-82 (2013). |
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| Acacetin inhibits expression of E-selectin on endothelial cells through regulation of the MAP kinase signaling pathway and activation of NF-κB N. Tanigawa, R. Isoda, M. Hagiwara, H. Tad, T. Komatsu, S. Sugiura, K. Kobayashi, Y. Kato, N. Ishida, K. Nishida, M. Ninomiya, M. Koketsu, K. Matsushita Immunopharmacology and Immunotoxycology, 35, 471-477 (2013). |
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| Cerodane diterpenes isolated from Polyalthia longifolia induce apoptosis in human leukemia HL-60 Cells Dina Permata Sari, Masayuki Ninomiya, Mai Efdi, Adlis Santoni, Sanusi Ibrahim, Kaori Tanaka, Mamoru Koketsu Journal of Oleo Science, 62(10), 843-848 (2013). |
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| Neurite outgrowth in PC12 cells stimulated by components from Dendranthema × grandiflorum cv. ‘Mottenohoka’ is enhanced by suppressing phosphorylation of p38MAPK A. Nishina, H. Kimura, H. Tsukagoshi, K. Kozawa, M. Koketsu, M. Ninomiya, S. Furukawa Evidence-Based Complementary and Alternative Medicine, 2013, Article ID 403503, 10 pages (2013). |
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| Structure-activity relationship studies of 5,7-dihydroxyflavones as naturally occurring inhibitors of cell proliferation in human leukemia HL-60 cells M. Ninomiya, K. Nishida, K. Tanaka, K. Watanabe, M. Koketsu Journal of Natural Medicine, 67(3), 460-467 (2013). |
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| Chemical constituents of Indonesian plant Protium javanicum Burm. f. and their antifeedant activities against Coptotermes formosanus Shiraki M. Adfa, Y. Hattori, M. Ninomiya, Y. Funahashi, T. Yoshimura, M. Koketsu Natural Product Research, 27(3), 270-273 (2013). |
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| Tricin inhibits proliferation of human hepatic stellate cells in vitro by blocking tyrosine phosphorylation of PDGF receptor and its signaling pathways N. Seki, U. Toh, K. Kawaguchi, M. Ninomiya, M. Koketsu, K. Watanabe, M. Aoki, T. Fujii, A. Nakamura, Y. Akagi, J. Kusukawa, M. Kage, K. Shirouzu, H. Yamana Journal of Cellular Biochemistry, 113, 2346-2355 (2012). |
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| Increased bioavailability of tricin-amino acid conjugates via a prodrug approach M. Ninomiya, K. Tanaka, Y. Tsuchida, Y. Muto, M. Koketsu, K. Watanabe Journal of Medicinal Chemistry, 54, 1529-1536 (2011). |
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| Biological significant selenium-containing heterocycles M. Ninomiya, D. R. Garud, M. Koketsu Coordination Chemistry Reviews, 255, 2968-2990 (2011). |
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| Antioxidant activity and chemical constituents of edible terrestrial alga Nostoc commune Vauch M. Ninomiya, H. Satoh, Y. Yamaguchi, H. Takenaka, M. Koketsu Bioscience, Biotechnology, and Biochemistry, 75, 2175-2177 (2011). |
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| Inhibitory effects of chalcone glycosides isolated from Brassica rapa L. 'hidabeni' and their synthetic derivatives on LPS-induced NO production in microglia H. Hara, Y. Nakamura, M. Ninomiya, R. Mochizuki, T. Kamiya, E. Aizenman, M. Koketsu, T. Adachi Bioorganic Medicinal Chemistry, 19, 5559-5568 (2011). |
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| Novel glycosaminoglycan biosynthetic inhibitors affect tumor-associated angiogenesis K. Raman, M. Ninomiya, T. K. N. Nguyen, Y. Tsuzuki, M. Koketsu, B. Kuberan Biochemical and Biophysical Research Communications, 404, 86-89 (2011). |
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| Selenium-containing heterocycles using selenoamides, selenoureas, selenazadienes, and isoselenocyanates M. Ninomiya, D. R. Gaud, M. Koketsu Heterocycles, 81, 2027-2055 (2010). |
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| Chalcone glycosides isolated from aerial parts of Brassica rapa L. ‘hidabeni’ suppress antigen-stimulated degranulation in rat basophilic leukemia RBL-2H3 cells T. Itoh, M. Ninomiya, Y. Nozawa, M. Koketsu Bioorganic Medicinal Chemistry, 18, 7052-7057 (2010). |
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| Selenium-containing bicyclic β-lactams
D. R. Garud, M. Ninomiya, M. Koketsu Heterocycles, 81, 2439-2463 (2010). |
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| Chalcone glycosides from aerial parts of Brassica rapa L. ‘hidabeni’, turnip
M. Ninomiya, M. Efdi, T. Inuzuka, M. Koketsu Phytochemistry Letters, 3, 96-99 (2010). |
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| Morroniside cinnamic acid conjugate as an anti-inflammatory agent
Y. Takeda, N. Tanigawa, F. Sunghwa, M. Ninomiya, M. Hagiwara, K. Matsushita, M. Koketsu Bioorganic Medicinal Chemistry Letters, 20, 4855-4857 (2010). |
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| Phenolic constituents isolated from Fragaria ananassa Duch. inhibit antigen-stimulated degranulation through direct inhibition of spleen tyrosine kinase activation
M. Ninomiya, T. Itoh, S. Ishikawa, M. Saiki, K. Narumiya, M. Yasuda, K. Koshikawa, Y. Nozawa, M. Koketsu Bioorganic Medicinal Chemistry, 18, 5932-5937 (2010). |
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| Isolation of chemical constituents from Enicosanthum cupulare (King) Airy-Shaw
S. Fujita, M. Ninomiya, M. Efdi, K. Ohguchi, Y. Nozawa, M. Koketsu Natural Product Research, 24, 1630-1636 (2010). |
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| クマザサ含有成分によるヒトサイトメガロウイルスの増殖抑制効果
K. Akuzawa, R. Yamada, C-.X. Bi, H. Sadanari, K. Matsubara, Y. Tsuchida, K. Watanabe, M. Ninomiya, M. Koketsu, T. Murayama 日本補完代替医療学会誌, 7, 25-33 (2010). |
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| Inhibitory effects of flavonoids isolated from Fragaria ananassa Duch on IgE-mediated degranulation in rat basophilic leukemia RBL-2H3
T. Itoh, M. Ninomiya, M. Yasuda, K. Koshikawa, Y. Deyashiki, Y. Nozawa, Y. Akao, M. Koketsu Bioorganic Medicinal Chemistry, 17, 5374-5379 (2009). |
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| Synthesis of 2-selenoxoperhydro-1,3-selenazin-4-ones via diselenocarbamate intermediates
D. R. Garud, N. Tanahashi, M. Ninomiya, M. Koketsu Tetrahedron, 65, 4775-4780 (2009). |
■ BACHELOR
| Kenji NARUMIYA (2007/4-) |
Isolation of bioactive compounds in Strawbery |
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Phenolic constituents isolated from Fragaria ananassa Duch. inhibit antigen-stimulated degranulation through direct inhibition of spleen tyrosine kinase activation M. Ninomiya, T. Itoh, S. Ishikawa, M. Saiki, K. Narumiya, M. Yasuda, K. Koshikawa, Y. Nozawa, M. Koketsu Bioorg. Med. Chem., 18, 5932-5937 (2010). |