|
|
| 研究業績 上野 |
2021
Kajino,
R. and Ueno, Y.*: (S)-5'-C-Aminopropyl-2'-O-methyl nucleosides enhance antisense activity in
cultured cells and binding affinity to complementary single-stranded RNA. Bioorg. Med. Chem. 30: 115925, 2021.
2020
上野義仁*，梶野瞭平: アンチセンス核酸の合成. In: 核酸科学ハンドブック．杉本直己 編．講談社，pp. 513-515, 2020．
Zhou,
Y., Kajino, R., Ishii, S., Yamagishi, K. and Ueno, Y.*: Synthesis
and evaluation of (S)-5'-C-aminopropyl and (S)-5'-C-aminopropyl-2'-arabinofluoro modified DNA oligomers for novel
RNase H-dependent antisense oligonucleotides. RSC Advances
10: 41901-41914, 2020.
Takeuchi,
A., Hisamatsu, K., Okumura, N., Sugimitsu, Y., Yanase, E., Ueno, Y. and Nagaoka,
S.: IIAEK targets intestinal alkaline phosphatase (IAP) to improve cholesterol
metabolism with a specific activation of iap and downregulation of ABCA1. Nutrients
12: 2859, 2020.
Matsubara,
M., Honda, K., Ozaki, K., Kajino, R., Kakisawa, Y., Maeda, Y. and Ueno, Y.*:
Synthesis of siRNAs incorporated with cationic peptides R8G7 and R8A7 and the
effect of the modifications on siRNA properties. RSC Advances 10: 34815-34824,
2020.
梶野瞭平，上野義仁*: アンチセンス核酸の毒性発現メカニズムと毒性発現低減に向けた科学的アプローチ. 日本核酸医薬学会誌, 35-43, 2020.
Tsuchihira,
T., Kajino, R., Maeda, Y. and Ueno, Y.*: 4'-C-Aminomethyl-2'-deoxy-2'-fluoroarabinonucleoside increases the nuclease
resistance of DNA without inhibiting the ability of a DNA/RNA duplex to activate RNase H. Bioorg. Med. Chem. 28:
115611, 2020.
Yoshikawa,
R., Heishima, K., Ueno, Y., Kawade, M., Maeda, Y., Yoshida, K., Murakami,
M., Sakai, H., Akao, Y. and Mori, T.: Development of synthetic microRNA-214 showing enhanced cytotoxicity and RNase resistance
for treatment of canine hemangiosarcoma. Veterinary and Comparative Oncology 18:
570-579, 2020.
Uematsu, A., Kajino, R.,
Maeda, Y. and Ueno, Y.*: Synthesis and characterization of 4'-C-guanidinomethyl-2'-O-methyl-modified
RNA oligomers. Nucleotides & Nucleic Acids 39: 280-291, 2020.
2019
Chandela,
A. and Ueno, Y.*: Design,
synthesis and evaluation of novel, branched trident small interfering RNA
nanostructures for sequence-specific RNAi activity. RSC Advances 9: 34166-34171, 2019.
Kajino, R., Maeda, Y., Yoshida, H., Yamagishi, K. and Ueno, Y.*: Synthesis and biophysical characterization of RNAs containing (R)- and
(S)-5'-C-aminopropyl-2'-O-methyluridines. J. Org. Chem. 84: 3388-3404,
2019.
Chandela, A., Watanabe, T., Yamagishi, K. and Ueno Y.*: Synthesis and characterization of small interfering RNAs with haloalkyl
groups at their 3'-dangling ends. Bioorg. Med. Chem. 27:1341-1349, 2019.
Chandela, A. and Ueno, Y.*: Systemic delivery of small interfering RNA therapeutics; obstacles and advances. Reviews in Agricultural Science 7: 10-28, 2019.
2018
Kano, T., Katsuragi, Y., Maeda, Y. and Ueno, Y.*: Synthesis and properties of 4'-C-aminoalkyl-2'-fluoro-modified RNA oligomers. Bioorg. Med. Chem. 26: 4574-4582, 2018.
Nakamoto, K., Akao, Y., Furuichi, Y. and Ueno, Y.*: Enhanced intercellular delivery of cRGD-siRNA conjugates by an additional
oligospermine modification. ACS Omega. 3: 8226-8232, 2018.
Nakamoto, K., Akao, Y. and Ueno, Y.*: Diazirine-containing tag-free RNA probes for efficient RISC-loading and
photoaffinity labeling of microRNA targets. Bioorg. Med. Chem. Lett. 28:
2906-2909, 2018.
Koizumi, K., Maeda, Y., Kano, T., Yoshida, H., Sakamoto, T., Yamagishi, K. and Ueno, Y.*: Synthesis of 4'-C-aminoalkyl-2'-O-methyl modified RNA and their biological properties. Bioorg. Med. Chem. 26: 521-3534, 2018.
2017
Maeda, Y., Niwa, N. and Ueno, Y.*: Synthesis of the phosphoramidite units for Benzene-glycol nucleic acid.
Curr. Protoc. Nucleic Acid Chem. 70:1.42.1-1.42.18, 2017.
Yokoyama, C., Nakamoto, K. and Ueno, Y.*: Design and synthesis of novel photoinduced electron transfer-based hybridization
probes. Bioorg. Med. Chem. 25: 3574-3582, 2017.
Niwa, N., Shimizu, S., Maeda, Y., Hiroaki, H. and Ueno, Y.*: Benzene-glycol nucleic acid (BGNA)-DNA chimeras: synthesis, binding properties,
and ability to elicit human RNase H activity. RSC Advances 7: 25378-25386,
2017.
Ogata, A., Maeda, Y. and Ueno, Y.*: Synthesis of antisense oligonucleotides containing acyclic alkynyl nucleoside analogs and their biophysical and biological properties. Bioorg. Med. Chem. 25: 2035-2042, 2017.
Kobayashi, Y., Tanahashi, R., Yamaguchi, Y., Hatae, N., Kobayashi, M.,
Ueno, Y. and Yoshimatsu, M.: Ni-Pd catalyzed cyclization of sulfanyl 1,6-diynes:
synthesis of 1'-homonucleoside analogues. J. Org. Chem. 82: 2436-2449,
2017.
2016
Hayai, A., Maeda, Y. and Ueno, Y.*: Synthesis of a fluorescence resonance energy transfer-based probe containing a tricyclic nucleoside analog for single nucleotide polymorphism typing. Bioorg. Med. Chem. Lett. 26: 3552-3555, 2016.
Nakamoto, K., Minami, K., Akao, Y. and Ueno, Y.*: Labeling of target mRNAs by a photo-reactive microRNA probe. Chem. Commun.
52: 6720-6722, 2016.
Niwa, N., Ueda, K. and Ueno, Y.*: Synthesis of benzene-glycol nucleic acids and their biophysical and biological
properties. Eur. J. Org. Chem. 14: 2435-2443, 2016.
2015
Inada, N., Nakamoto, K., Yokogawa, T. and Ueno, Y.*: Synthesis of small interfering RNAs containing acetal-type nucleoside
analogs at their 3'-ends and analysis of their silencing activity and their
ability to bind to the Argonaute2 PAZ domain. Eur. J. Med. Chem. 103: 460-472,
2015.
Takahashi, K., Ito, S., Nakamoto, K., Ito, Y. and Ueno, Y.*: Photoinduced electron transfer-based hybridization probes for detection
of DNA and RNA. J. Org. Chem. 80: 8561-8570, 2015.
Ogata, A. and Ueno, Y.*: Incorporation of an acyclic alkynyl nucleoside analog into siRNA improves
silencing activity and nuclease resistance. Bioorg. Med. Chem. Lett. 25:
2574-2578, 2015.
Moriya, A., Ohki, T., Hayai, A and Ueno, Y.*: Development of a probe containing novel fluorescent tricyclic-nucleoside
analog for detecting single nucleoside polymorphisms. Heterocycles 91:
515-525, 2015.
2014
Nakamoto, K. and Ueno, Y.*: Diazirine-containing RNA photo-crosslinking probes for capturing microRNA
targets. J. Org. Chem. 79: 2463-2472, 2014.
Kitamura, Y., Ueno, Y. and Kitade, Y.: Synthesis of acetylene-substituted probes with benzene-phosphate backbones for RNA labeling. Current Protocols in Nucleic Acid Chemistry, DOI: 10.1002/0471142700.nc0459s57.
2013
Iwata, M., Ogata, A., Ito, Y. and Ueno, Y.*: Synthesis, thermal stability and photochemical properties of DNA containing fluorescent biary-type nucleoside surrogates. J. Chem. Chem. Eng. 7: 962-971, 2013.
Kitamura, Y., Masegi, Y., Ogawa, S., Nakashima, R., Akao, Y., Ueno, Y. and Kitade, Y.: Chemically modified siRNAs and miRNAs bearing urea/thiourea-bridged
aromatic compounds at their 3′-end for RNAi therapy. Bioorg. Med. Chem.
21: 4494-4501, 2013.
原口 健，上野義仁，伊庭英夫: microRNA 阻害法の開発：「TuD RNA 発現ベクター」と「S-TuD」. Antisense. 17: 15-25,
2013.
2012
| Hirata, Y., Furuta, K., Suzuki, M., Oh-hashi, K., Ueno, Y. and Kiuchi, K.: Neuroprotective cyclopentenone prostaglandins up-regulate
neurotrophic factors in C6 glioma cells. Brain Res. 1482: 91-100, 2012. |
| |
| Shibata, A., Ueno, Y.*, Iwata, M., Wakita, H., Matsuda, A. and Kitade, Y.: Double-stranded oligonucleotides
containing 5-aminomethyl-2′-deoxyuridine form thermostable anti-parallel
triplexes with single-stranded DNA or RNA, Bioorg. Med. Chem. Lett. 22:
2681-2683, 2012. |
| Haraguchi, T., Nakano, H., Tagawa, T., Ohki, T., Ueno, Y., Yoshida, T. and Iba, H.: A potent 2′-O-methylated RNA based microRNA
inhibitor with unique secondary structures, Nucleic Acids Res. 40: 1-13,
2012. |
| |
| Hattori, M., Ohki, T., Yanase, E. and Ueno, Y.*: Fluorescence detection of single nucleotide polymorphisms using nucleic
acid probe containing tricyclic base-linked acyclonucleoside, Bioorg. Med.
Chem. Lett. 22: 253-257, 2012. |
| |
| Furukawa, K., Hattori, M., Ohki, T., Kitamura, Y., Kitade, Y. and Ueno, Y.*: Nucleic acid probe containing fluorescent tricyclic base-linked acyclonucleoside
for detection of single nucleotide polymorphisms, Bioorg. Med. Chem. 20:
16-24, 2012. |
| |
| 2011 |
| Sakurai, K., Furukawa, C., Haraguchi, T., Inada, K., Shiogama, K., Tagawa, T., Fujita, S., Ueno, Y., Ogata, A., Ito, M., Tsutsumi, Y. and Iba, H.: microRNAs miR-199a-5p and -3p target the Brm subunit of SWI/SNF to generate a double-negative feedback loop in a variety of human cancers, Cancer Res. 71: 1680-1689, 2011. |
| |
| Shiraishi, T., Kitamura, Y., Ueno, Y. and Kitade, Y.: Synthesis of oligonucleotides possessing versatile probes
for PET labelling and their rapid ligand-free click reaction, Chem. Commun.
47: 2691-2693, 2011. |
| |
| Yoshikawa, K., Ogata, A., Matsuda, C., Kohara, M., Iba, H., Kitade, Y.
and Ueno, Y.*: Incorporation of
biaryl units into the 5′ and 3′ ends of sense and antisense strands of
siRNA duplexes improves strand selectivity and nuclease resistance,
Bioconjugate Chem. 22: 4-49, 2011. |
| |
| 2010 |
| Tsunoda, M., Sakaue, T., Naito, S., Sunami, T., Abe, N., Ueno, Y., Matsuda and Takenaka, A.: Insights into the mutagenic structures of DNA damaged by hydroxyl radical, XI: crystal structures of DNA duplexes containing 5-formyluracil, Journal of Nucleic Acids 2010: 107289, 2010. |
| |
| Ogata, A., Furukawa, C., Sakurai, K., Iba, H., Kitade, Y. and Ueno, Y.*:
Biaryl modification of the 5′-terminus of one strand of a microRNA
duplex induces strand specificity, Bioorg. Med. Chem. Lett. 20:
7299-7302, 2010. |
| |
| Kuboe, S., Yoda, M., Ogata, A., Kitade, Y., Tomari, Y.* and Ueno, Y.*: Diazirine-containing RNA photocrosslinking probes for the study of siRNA-protein
interactions, Chem. Commun. 46: 7367-7369, 2010. |
| |
| Nagaoka, K., Kitamura, Y., Ueno, Y. and Kitade, Y.: 5′-O-Dephosphorylated 2′,5′-oligoadenylate (2-5A) with 8-methyladenosine at the 2′-terminus activates human RNase L, Bioorg. Med. Chem. Lett. 20: 1186-1188, 2010. |
| |
| 2009 |
| Ueno, Y.*, Komatsuzaki, S., Takasu, K., Kawai, S., Kitamura, Y. and Kitade, Y.:
Synthesis and properties of oligonucleotides containing novel fluorescent
biaryl units, Eur. J. Org. Chem. 28: 4763-4769, 2009. (Cover Picture) |
| |
| Ueno, Y.*,
Kawamura, A., Takasu, K., Komatsuzaki, S., Kato, T., Kuboe, S.,
Kitamura, Y. and Kitade, Y.: Synthesis and properties of a novel
molecular beacon containing a benzene-phosphate backbone at its stem
moiety, Org. Biomol. Chem. 7: 2761-2769, 2009. |
| |
| Ueno, Y.*, Watanabe, Y., Shibata, A., Yoshikawa, K., Takano, T., Kohara, M. and
Kitade, Y.: Synthesis of nuclease-resistant siRNAs possessing universal
overhangs, Bioorg. Med. Chem. 17: 1974-1981, 2009. |
| |
| Ueno, Y.*, Yoshikawa, K., Kitamura, Y. and Kitade, Y.: Effect of incorporation of
alkyl linkers into siRNAs on RNA interference, Bioorg. Med. Chem. Lett.
19: 875-877, 2009. |
| |
| Nagaoka, K., Kito, S., Kitamura, Y., Ueno, Y. and Kitade, Y.: Introduction of 8-methyladenosine into 2′,5′-oligoadenylate
(2-5A) 2′-terminus induces dramatic shift in binding site of RNase L. Nucleic
Acids Sympo. Ser. 53: 123-124, 2009. |
| |
| Ueno, Y., Komatsuzaki, S., Takasu, K., Kitamura, Y. and Kitade, Y.: Synthesis and
properties of oligodeoxynucleotides containing biaryl units. Nucleic Acids
Sympo. Ser. 53: 27-28, 2009. |
| |
| 2008 |
| Ueno, Y.*,
Hirai, M., Yoshikawa, K., Kitamura, Y., Hirata. Y., Kiuchi, K. and
Kitade, Y.: Synthesis and properties of siRNAs containing
5′-amino-2′,5′-dideoxy-2′α-fluororibonucleosides, Tetrahedron 64:
11328-11334, 2008. |
| |
| Ueno, Y.*, Inoue, T., Yoshida, M., Yoshikawa, K., Shibata, A., Kitamura, Y. and
Kitade, Y.: Synthesis of nuclease-resistant siRNAs possessing benzene-phosphate
backbones in their 3′-overhang regions. Bioorg. Med. Chem. Lett. 18: 5194-5196,
2008. |
| |
| Ueno, Y.*, Kawada, K., Naito, T., Shibata, A., Yoshikawa, K., Kim, H.-S., Wataya,
Y. and Kitade, Y.: Synthesis and silencing properties of siRNAs possessing
lipophilic groups at their 3′-termini. Bioorg. Med. Chem. 16: 7698-7704,
2008. |
| |
| Lee, S., Bowman, B. R., Ueno, Y., Wang, S. and Verdine, G. L.: Synthesis and Structure of Duplex DNA Containing
the Genotoxic Nucleobase Lesion N7-Methylguanine. J. Am. Chem. Soc. 130:
11570-11571, 2008. |
| |
| Kandeel, M., Nakanishi, M., Ando, T., El-Shazly, K., Yosef, T., Ueno, Y. and Kitade, Y.: Molecular cloning, expression, characterization and mutation of Plasmodium falciparum guanylate kinase. Molecular & Biochemical Parasitology, 159, 130-133 (2008). |
| |
| Banno, Y., Nemoto, S., Murakami, M., Kimura, M., Ueno, Y., Ohguchi, K., Hara, A., Okano, Y., Kitade, Y., Onozuka, M., Murate, T.
and Nozawa, Y.: Depolarization-induced differentiation of PC12 cells is
mediated by phospholipase D2 through the transcription factor CREB pathway.
Journal of Neurochemistry 104: 1372-1386, 2008. |
| |
| Ueno, Y., Kawada, K., Shibata, A., Yoshikawa, K., Wataya, Y. and Kitade, Y.: Synthesis
and silencing properties of siRNAs possessing lipophilic groups at their
3′-termini. Nucleic Acids Sympo. Ser. 52: 503-504, 2008. |
| |
| 2007 |
| Murata, S., Mizumura, Y., Hino, K., Ueno, Y., Ichikawa, S. and Matsuda, A.: Modular bent DNAs: A new
class of artificial DNAs with a protein binding ability, J. Am. Chem. Soc. 129:
10300-10301, 2007. |
| |
| Juan, E. C. M., Kondo, J., Kurihara, T., Ito, T., Ueno, Y., Matsuda A. and Takenaka, A.: Crystal structures of DNA:DNA and DNA:RNA duplexes containing 5-(N-aminohexyl)carbamoyl-modified uridines reveal the basis for antigene and antisense properties, Nucleic Acids Res. 35: 1969-1977, 2007. |
| |
| Tsuruta, T., Oh-hashi, K., Ueno, Y., Kitade, Y., Kiuchi K. and Hirata, Y.: RNAi knockdown of caspase-activated
DNase inhibits rotenone-induced DNA fragmentation in HeLa cells, Neurochemistry
International 50: 601-606, 2007. |
| |
| Nakamura, T., Ito, Y., Mochizuki, M., Ueno, Y. and Kitade, Y.: Synthesis of 2′,5′-oligoadenylate analogs possessing a
linker moiety in the place of the adenosine and their ability to activate
human RNase L. Nucleic Acids Sympo. Ser. 51: 449-450, 2007. |
| |
| Ueno, Y., Kawamura, A., Kato, T. and Kitade, Y.: Synthesis and properties of a novel molecular beacon containing a benzene-phosphate backbone at a stem moiety. Nucleic Acids Sympo. Ser. 51: 293-294, 2007. |
| |
| 2006 |
| Kitade, Y., Ando, T., Yamaguchi, T., Hori, A., Nakanishi, M. and Ueno, Y.: 4′-Fluorinated carbocyclic nucleosides: synthesis and inhibitory activity
against S-adenosyl-L-homocysteine hydrolase, Bioorg. Med. Chem. 14: 5578-5583,
2006. |
| |
| Ueno, Y., Ishihara, S., Ito, Y. and Kitade, Y.: Synthesis and hybridization properties
of oligonucleotides containing (2S,3R)-9-(2,3,4-trihydroxybutyl)adenine.
Nucleosides, Nucleotides, Nucleic Acids 25: 475-487, 2006. |
| |
| Shibata, A., Ueno, Y., Shinbo, K., Nakanishi, M., Matsuda, A. and Kitade, Y.: Synthesis of linked triple helical DNAs possessing high affinity to triple helical DNA binding protein. Bioorg. Med. Chem. Lett. 16: 1410-1413, 2006. |
| |
| Shibata, A., Ueno, Y., Nakanishi, M., Matsuda, A., and Kitade, Y.: Synthesis and properties
of double-stranded antisense oligonucleotides connected with a pentaerythritol
linker. Nucleic Acids Sympo. Ser. 50: 73-74, 2006. |
| |
| 2005 |
| Nakanishi, M., Tanaka, N., Mizutani, Y., Mochizuki, M., Ueno, Y., Nakamura, K. T., Kitade, Y.: Functional characterization of 2-5A binding
determinant of human RNase L. J. Biol. Chem. 280: 41694-41699, 2005. |
| |
| Ueno, Y., Kato, T., Sato, K., Ito, Y., Yoshida, M., Inoue, T., Shibata, A., Ebihara,
M. and Kitade, Y.: Synthesis and properties of nucleic acid analogs consisting
of a benzene-phosphate backbone. J. Org. Chem. 70: 7925-7935, 2005. |
| |
| Ueno, Y., Naito, T., Kawada, K., Shibata, A., Kim, H.-S., Wataya, Y. and Kitade, Y.: Synthesis of novel siRNAs having thymidine dimers consisting of a carbamate or a urea linkage at their 3′ overhang regions and their ability to suppress human RNase L protein expression. Biochem. Biophys. Res. Comm. 330: 1168-1175, 2005. |
| |
| Shibata, A., Ueno, Y., Nakanishi, M., Matsuda, A. and Kitade, Y.: Synthesis of cross-linked
triple helical DNAs possessing high affinity to triple helical DNA binding
protein. Nucleic Acids Sympo. Ser. 49: 183-184, 2005. |
| |
| Juan, E. C. M., Kondo, J., Ito, T., Ueno, Y., Matsuda, A. and Takenaka, A.: X-Ray analyses of hybrid duplexes between
antisense oligonucleotides containing 5-(N-aminohexyl)carbamoyl-2′-O-methyluridine
and their target RNAs. Nucleic Acids Sympo. Ser. 49: 65-66, 2005. |
| |
| 2004 |
| Ueno, Y., Shibata, A., Matsuda, A. and Kitade, Y.: Thermal stability of triple
helical DNAs containing 2′-deoxyinosine and 2′-deoxyxanthosine. Bioorg.
Med. Chem. 12: 6581-6586, 2004. |
| |
| Ueno, Y., Ishihara, S., Ito, Y. and Kitade. Y.: Synthesis of 2′,5′-oligoadenylate analogs containing an adenine acyclonucleoside and their ability to activate human RNase L. Bioorg. Med. Chem. Lett. 14: 4431-4434, 2004. |
| |
| Nakanishi, M., Yoshimura, A., Ishida, N., Ueno, Y. and Kitade, Y.: Contribution of Tyr712 and Phe716 to the activity of human
RNase L. Eur. J. Biochem. 271: 2737-2744, 2004. |
| |
| Yamamoto, Y., Shuto, S., Tamura, Y., Kodama, T., Hoshika, S., Ichikawa, S., Ueno, Y., Ohtsuka, E., Komatsu, Y. and Matsuda, A.: Oligodeoxynucleotides having
a loop consisting of 3′-deoxy-4′-C-(2-hydroxyethyl)thymidines form stable
hairpins. Biochemistry 43: 8690-8699, 2004. |
| |
| Hoshika, S., Ueno, Y., Kamiya, H. and Matsuda, A.: Nucleosides and Nucleotides. Part 226: Alternate-strand triple-helix formation by 3′-3′-linked oligodeoxynucleotides composed of asymmetrical sequences. Bioorg. Med. Chem. Lett. 14: 3333-3336, 2004. |
| |
| Juan, E. C. M., Kurihara, T., Kondo, J., Ito, T., Ueno, Y., Matsuda, A. and Takenaka, A.: X-Ray analyses of DNA duplexes containing
5-(N-aminohexyl)carbamoyl modifications. Nucleic Acids Sympo. Ser. 48:
305-306, 2004. |
| |
| Shuto, S., Tamura, Y., Yamamoto, Y., Kodama, T., Hoshika, S., Ichikawa, S., Ueno, Y., Ohtsuka, E., Komatsu, Y. and Matsuda, A.: Stable hairpins having a loop
consisting of 3′-deoxy-4′-C-(2-hydroxyethyl)thymidines. Nucleic Acids Sympo.
Ser. 48: 67-68, 2004. |
| |
| Ueno, Y., Kato, T., Sato, K., Ito, Y., Ebihara, M., Jiye, J. and Kitade, Y.: Synthesis and properties of DNA analogs consisting of the benzene?phosphate backbone. Nucleic Acids Sympo. Ser. 48: 17-18, 2004. |
| |
| 2003 |
| Ueno, Y., Yamada, Y., Nakanishi, M. and Kitade, Y.: A specific substrate-inhibitor, a 2′-deoxy-2′-fluorouridine-containing oligoribonucleotide, against human RNase L. Bioorg. Med. Chem. 11: 5069-5073, 2003. |
| |
| Ueno, Y., Okatani, S., Yamada, Y. and Kitade, Y.: Synthesis of double-Headed 2-5A-Antisense
chimeras and their ability to activate human RNase L. Bioorg. Med. Chem.
Lett. 13: 3959-3961, 2003. |
| |
| Minakawa, N., Kojima, N., Hikishima, S., Sasaki, T., Kiyosue, A., Atsumi,
N., Ueno, Y. and Matsuda, A.: New base pairing motifs. The synthesis and thermal stability
of oligodeoxynucleotides containing imidazopyridopyrimidine nucleosides
with the ability to form four hydrogen bonds. J. Am. Chem. Soc. 125: 9970-9982,
2003. |
| |
| Ito, T., Ueno, Y., Komatsu, Y. and Matsuda, A.: Synthesis, thermal stability and resistance to enzymatic hydrolysis of the oligonucleotides containing 5-(N-aminohexyl)carbamoyl-2′-O-methyluridines. Nucleic Acids Res. 31: 2514-2523, 2003. |
| |
| Ueno, Y., Kato, Y., Okatani, S., Ishida, N., Nakanishi, M. and Kitade, Y.: Synthesis
of antisense oligonucleotides carrying modified 2-5A molecules at their
5′-termini and their properties. Bioconjugate Chem. 14: 690-696, 2003. |
| |
| Ueno, Y., Shibata, A., Matsuda, A. and Kitade, Y.: Synthesis of 3′-3′-linked oligonucleotides
branched by a pentaerythritol linker and the thermal stabilities of the
triplexes with single-stranded DNA or RNA. Bioconjugate Chem. 14: 684-689,
2003. |
| |
| Hoshika, S., Ueno, Y. and Matsuda, A.: Nucleosides and Nucleotides. 218. Alternate-strand triple-helix formation by the 3′-3′-linked oligodeoxynucleotides using a purine motif. Bioconjugate Chem. 14: 607-613, 2003. |
| |
| Ueno, Y., Yamada, Y. and Kitade, Y.: Analysis of cleavage pattern of RNA analogs
containing 2'-modified nucleosides by human recombinant RNase L. Peptide
Science: 457-458, 2003. |
| |
| Ueno, Y., Okatani, S., Yamada, Y. and Kitade, Y.: Synthesis of double-headed 2-5A-antisense
chimeras and their ability to activate human RNase L. Nucleic Acids Research
Supplement: 63-64, 2003. |
| |
| Kitade, Y., Kojima, H., Zulfiqur, F., Yabe, S., Yamagiwa, D., Ito, Y., Nakanishi, M., Ueno, Y., Kim, H.-S. and Wataya, Y.: Synthesis of carbocyclic and acyclic nucleosides possessing 2-fluoroadenine derivatives and their inhibitory activities against Plasmodium falciparum SAH hydrolase. Nucleic Acids Research Supplement: 5-6, 2003. |
| |
| 2002 |
| Kamiya, H., Tsuchiya, H., Karino, N., Ueno, Y., Matsuda, A. and Harashima, H.: Mutagenicity of 5-formylcytosine, an oxidation product of 5-methylcytosine, in DNA in mammalian cells. J. Biochem. (Tokyo, Japan)
132: 551-555, 2002. |
| |
| Atsumi, N., Ueno, Y., Kanazaki, M., Shuto, S. and Matsuda, A.: Nucleosides and Nucleotides.
Part 214: thermal stability of triplexes containing 4′α-C-aminoalkyl-2′-deoxynucleosides.
Bioorg. Med. Chem. 10: 2933-2939, 2002. |
| |
| Tsunoda, M., Kondo, J., Karino, N., Ueno, Y., Matsuda, A. and Takenaka, A.: Water mediated Dickerson-Drew-type crystal
of DNA dodecamer containing 2′-deoxy-5-formyluridine. Biophys. Chem. 95:
227-233, 2002. |
| |
| Hossain, M. T., Kondo, J., Ueno, Y., Matsuda, A. and Takenaka, A.: X-ray analysis of d(CGCGAATTXGCG)2 containing a 2′-deoxy-N4-methoxycytosine residue at X: a characteristic pattern of sugar puckers in the crystalline state of the Dickerson-Drew type DNA dodecamers. Biophys. Chem. 95: 69-77, 2002. |
| |
| Kamiya, H., Murata-Kamiya, N., Karino, N., Ueno, Y., Matsuda, A. and Kasai, H.: Induction of T→G and T→A transversions by 5-formyluracil in mammalian
cells. Mutation Res. 513: 213-222, 2002. |
| |
| Kojima, H., Yamaguchi, T., Kozaki, A., Nakanishi, M., Ueno, Y. and Kitade, Y.: Synthesis of noraristeromycin analogues possessing SAH
hydrolase inhibitory activity for the development of antimalaria agents.
Nucleic Acids Research Supplement: 141-142, 2002. |
| |
| Ueno, Y., Kato, Y., Okatani, S. and Kitade, Y.: Synthesis of the antisense oligonucleotides carrying the modified 2-5A molecules at their 5′-termini and their properties. Nucleic Acids Research Supplement: 45-46, 2002. |
| |
| 2001 |
| Hossain, M. T., Sunami, T., Tsunoda, M., Hikima, T., Chatake, T., Ueno, Y., Matsuda, A. and Takenaka, A.: Crystallographic studies on damaged DNAs IV. N4-Methoxycytosine shows a second face for Watson-Crick base-pairing, leading to purine transition mutagenesis. Nucleic Acids Res. 29: 3949-3954, 2001. |
| |
| Fukuoka, M., Shuto, S., Minakawa, N., Ueno, Y. and Matsuda, A.: Synthesis and biological activities of cyclic ADP-carbocyclic-ribose
and its analogs. Nucleosides, Nucleotides & Nucleic Acids 20: 1355-1358,
2001. |
| |
| Hossain, M. T., Chatake, T., Hikima, T., Tsunoda, M., Sunami, T., Ueno, Y., Matsuda, A. and Takenaka, A.: Crystallographic studies on damaged DNAs:
III. N4-Methoxycytosine can form both Watson-Crick type and wobbled base
pairs in a B-form duplex. J. Biochem. (Tokyo, Japan)
130: 9-12, 2001. |
| |
| Shuto, S., Fukuoka, M., Manikowsky, A., Ueno, Y., Nakano, T., Kuroda, R., Kuroda, H. and Matsuda, A.: Total synthesis of cyclic ADP-carbocyclic-ribose, a stable mimic of Ca2+-mobilizing second messenger cyclic ADP-ribose. J. Am. Chem. Soc. 123: 8750-8759, 2001. |
| |
| Karino, N., Ueno, Y. and Matsuda, A.: Synthesis and properties of oligonucleotides containing
5-formyl-2′-deoxycytidine: in vitro DNA polymerase reactions on DNA templates
containing 5-formyl-2′-deoxycytidine. Nucleic Acids Res. 29: 2456-2463,
2001. |
| |
| Ueno, Y., Mikawa, M., Hoshika, S. and Matsuda, A.: Nucleosides and Nucleotides.
208. Alternate-strand triple-helix formation by the 3′-3′-linked oligodeoxynucleotides
with the anthraquinonyl group at the junction point. Bioconjugate Chem.
12: 635-642, 2001. |
| |
| Anensen, H., Provan, F., Lian, A. T., Reinertsen, S. H., Ueno, Y., Matsuda, A., Seeberg, E. and Bjelland, S.: Mutations induced by 5-formyl-2′-deoxyuridine in Escherichia coli include base substitutions that can arise from mispairs of 5-formyluracil with guanine, cytosine and thymine. Mutation Res. 476: 99-107, 2001. |
| |
| Klungland, A., Paulsen, R., Rolseth, V., Yamada, Y., Ueno, Y., Wiik, P., Matsuda, A., Seeberg, E. and Bjelland, S.: 5-Formyluracil and
its nucleoside derivatives confer toxicity and mutagenicity to mammalian
cells by interfering with normal RNA and DNA metabolism. Toxicol. Lett.
119: 71-78, 2001. |
| |
| Tsunoda, M., Karino, N., Ueno, Y., Matsuda, A. and Takenaka, A.: Crystallization and preliminary X-ray analysis
of a DNA dodecamer containing 2′-deoxy-5-formyluridine; what is the role
of magnesium cation in crystallization of Dickerson-type DNA dodecamers?
Acta Cryst. D Biol. Crystallogr. 57: 345-348, 2001. |
| |
| Kozaki, A., Zulfiqar, F., Ueno, Y. and Kitade, Y.: Synthesis of carbocyclic nucleosides as potential antiviral agents. Nucleic Acids Research Supplement: 59-60, 2001. |
| |
| Ueno, Y., Mikawa, M., Hoshika, S., Takeba, M., Kitade, Y. and Matsuda, A.: Alternate-strand
triple-helix formation by the 3′-3′-linked oligodeoxynucleotides with the
intercalators at the junction point. Nucleic Acids Research Supplement:
11-12, 2001. |
| |
| Shuto, S., Kudoh, T., Fukuoka, M., Ueno, Y. and Matsuda, A.: Synthesis and biological activity of cyclic ADP-carbocyclic-ribose
and its analogs as stable mimics of Ca2+-mobilizing second messenger cyclic
ADP-ribose. Nucleic Acids Research Supplement: 5-6, 2001. |
| |
| Tsunoda, M., Sakaue, T., Naito, S., Sunami, T., Karino, N., Ueno, Y., Matsuda, A. and Takenaka, A.: X-Ray analyses of DNA dodecamers containing 2′-deoxy-5-formyluridiwne. Nucleic Acids Research Supplement: 279-280, 2001. |
| |
| 2000 |
| Ueno, Y., Tomino, K., Sugimoto, I.
and Matsuda, A.: Nucleosides and Nucleotides. Part 206: Introduction of
lipophilic groups into 4′α-C-(2-aminoethyl)thymidine-containing phosphodiester
oligodeoxynucleotides and thermal stabilities of the duplexes. Tetrahedron 56:
7903-7907, 2000. |
| |
| Ueno, Y., Karino, N. and Matsuda, A.: Nucleosides and Nucleotides. 204. Synthesis
of oligodeoxynucleotides containing 6′α-[N-(aminoalkyl)carbamoyloxy]-carbocyclic-thymidines
and the thermal stability of the duplexes and their nuclease-resistance
properties. Bioconjugate Chem. 11: 933-940, 2000. |
| |
| Fukuoka, M., Shuto, S., Minakawa, N., Ueno, Y. and Matsuda, A.: An efficient synthesis of cyclic IDP- and cyclic 8-bromo-IDP-carbocyclic-riboses
using a modified Hata condensation method to form an intramolecular pyrophosphate
linkage as a key step. An entry to a general method for the chemical synthesis
of cyclic ADP-ribose analogs. J. Org. Chem. 65: 5238-5248, 2000. |
| |
| Sumita, Y., Shirato, M., Ueno, Y., Matsuda, A. and Shuto, S.: Nucleosides and Nucleotides. 192. Toward the total synthesis of cyclic ADP-carbocyclic-ribose. Formation of the intramolecular pyrophosphate linkage by a conformation-restriction strategy in a syn-form using a halogen substitution at the 8-position of the adenine ring. Nucleosides, Nucleotides & Nucleic Acids 19: 175-187, 2000. |
| |
| Kanazaki, M., Ueno, Y., Shuto, S. and Matsuda, A.: Highly nuclease-resistant phosphodiester-type
oligodeoxynucleotides containing 4′α-C-aminoalkylthymidines form thermally
stable duplexes with DNA and RNA. A candidate for potent antisense molecules.
J. Am. Chem. Soc. 122: 2422-2432, 2000. |
| |
| Hossain, M. T., Hikima, T., Tsunoda, M., Chatake, T., Ueno, Y., Matsuda, A. and Takenaka, A.: X-Ray analyses of two DNA dodecamers containing
N4-methoxy-cytosine paired with adenine or guanine. Nucleic Acids Sympo.
Ser.: 239-240, 2000. |
| |
| Kamiya, H., Murata-Kamiya, N., Karino, N., Ueno, Y., Matsuda, A. and Kasai, H.: Mutagenicity of
5-formyluracil in mammalian cells. Nucleic Acids Sympo. Ser.: 81-82, 2000. |
| |
| 1999 |
| Chatake, T., Hikima, T., Ono, A., Ueno, Y., Matsuda, A. and Takenaka, A.: Crystallographic studies on damaged DNAs. II. N6-Methoxyadenine can present two alternate faces for Watson-Crick base-pairing, leading to pyrimidine transition mutagenesis. J. Mol. Biol. 294: 1223-1230, 1999. |
| |
| Chatake, T., Ono, A., Ueno, Y., Matsuda, A. and Takenaka, A.: Crystallographic studies on damaged DNAs.
I. An N6-methoxyadenine residue forms a Watson-Crick pair with a cytosine
residue in a B-DNA duplex. J. Mol. Biol. 294: 1215-1222, 1999. |
| |
| Murata-Kamiya, N., Kamiya, H., Karino, N., Ueno, Y., Kaji, H., Matsuda, A. and Kasai, H.: Formation of 5-formyl-2′-deoxycytidine from 5-methyl-2′-deoxycytidine
in duplex DNA by Fenton-type reactions and γ-irradiation. Nucleic Acids
Res. 27: 4385-4390, 1999. |
| |
| Ueno, Y., Kanazaki, M., Shuto, S. and Matsuda, A.: Synthesis of oligodeoxynucleotides containing 4′-C-aminoalkylthymidines and their thermal stability and nuclease-resistance properties. Nucleosides & Nucleotides 18: 1401-1402, 1999. |
| |
| Fukuoka, M., Shuto, S., Minakawa, N., Ueno, Y. and Matsuda, A.: Nucleosides and Nucleotides. 187. Alternative synthesis
of cyclic IDP-carbocyclic ribose. Efficient cyclization of an 8-bromo-N1-[5-(phosphoryl)carbocyclic-ribosyl]inosine
5′-phenylthiophosphate derivative mediated by iodine. Tetrahedron Lett.
40: 5361-5364, 1999. |
| |
| Chatake, T., Sunami, T., Ono, A., Ueno, Y., Matsuda, A. and Takenaka, A.: Crystallization and preliminary analysis
of a DNA dodecamer of d(CGCGmo6AATCCGCG) containing 2'-deoxy-N6-methoxyadenosine:
change in crystal packing with different humidity. Acta Cryst. D Biol.
Crystallogr. 55: 873-876, 1999. |
| |
| Ueno, Y., Takeba, M., Mikawa, M. and Matsuda, A.: Nucleosides and Nucleotides.
182. Synthesis of branched oligodeoxynucleotides with pentaerythritol at
the branch point and their thermal stabilization of triplex formation.
J. Org. Chem. 64: 1211-1217, 1999. |
| |
| Chatake, T., Ono, A., Ueno, Y., Matsuda, A. and Takenaka, A.: N6-Methoxyadenine in damaged DNA has two
faces in property of Watson-Crick base pairing. Nucleic Acids Sympo. Ser.:
121-122, 1999. |
| |
| Hikima, T., Hossain, M. T., Chatake, T., Ueno, Y., Matsuda, A. and Takenaka, A.: X-Ray analysis of a DNA dodecamer containing
2′-deoxy-N4-methoxycytidine. Nucleic Acids Sympo. Ser.: 49-50, 1999. |
| |
| Fukuoka, M., Shuto, S., Minakawa, N., Ueno, Y. and Matsuda, A.: Synthetic study on carbocyclic analogs of cyclic ADP-ribose, a novel second messenger: an efficient synthesis of cyclic IDP-carbocyclic-ribose. Nucleic Acids Sympo. Ser.: 11-12, 1999. |
| |
| Ikemoto, N., Kim, H.-S., Kanazaki, M., Ueno, Y., Shuto, S., Matsuda, A. and Wataya, Y.: Antisense oligodeoxynucleotides:
useful tool for search and assessment of new targets for anti-malarial
drugs. Nucleic Acids Sympo. Ser.: 89-90, 1999. |
| |
| 1998 |
| Nishizono, N., Sumita, Y., Ueno, Y. and Matsuda, A.: Effects of 2′-O-(trifluoromethyl)adenosine on oligodeoxynucleotide
hybridization and nuclease stability. Nucleic Acids Res. 26: 5067-5072,
1998. |
| |
| Shuto, S., Tatani, K., Ueno, Y. and Matsuda, A.: Synthesis of adenophostin analogs lacking the adenine
moiety as novel potent IP3 receptor ligands: some structural requirements
for the significant activity of adenophostin A. J. Org. Chem. 63: 8815-8824,
1998. |
| |
| Shuto, S., Shirato, M., Sumita, Y., Ueno, Y. and Matsuda, A.: Synthetic studies of carbocyclic analogs of cyclic ADP-ribose. Formation of cyclic dimer, a 36-membered-ring product, in the condensation reaction of an 8-bromo-N1-[5-(phenylthiophosphoryl)carbocyclic-ribosyl]inosine 5′-phosphate derivative mediated by AgNO3. Tetrahedron Lett. 39: 7341-7344, 1998. |
| |
| Tatani, K., Shuto, S., Ueno, Y. and Matsuda, A.: Synthesis of 1-O-[(3S,4R)-3-hydroxytetrahydrofuran-4-yl]-α-D-glucopyranoside
3,4,3′-trisphosphate as a novel potent IP3 receptor ligand. Tetrahedron
Lett. 39: 5065-5068, 1998. |
| |
| Ueno, Y., Nakagawa, A. and Matsuda, A.: Nucleosides and nucleotides. 165. Chemical
ligation of oligodeoxyribonucleotides having a mercapto group at the 5-position
of 2′-deoxyuridine via a disulfide bond. Nucleosides & Nucleotides
17: 283-289, 1998. |
| |
| Ueno, Y., Nagasawa, Y., Sugimoto, I.,
Kojima, N., Kanazaki, M., Shuto, S. and Matsuda, A.: Nucleosides and
Nucleotides. 174. Synthesis of oligodeoxynucleotides containing 4′-C-[2-[[N-(2-aminoethyl)carbamoyl]oxy]ethyl]thymidine
and their thermal stability and nuclease-resistance properties. J. Org. Chem.
63: 1660-1667, 1998. |
| |
| Shuto, S., Shirato, M., Sumita, Y., Ueno, Y. and Matsuda, A.: Nucleosides and Nucleotides. 173. Synthesis of cyclic
IDP-carbocyclic-ribose, a stable mimic of cyclic ADP-ribose. Significant
facilitation of the intramolecular condensation reaction of N-1-(carbocyclic-ribosyl)inosine
5′,6′′-diphosphates derivatives by an 8-bromo-substitution at the hypoxanthine
moiety. J. Org. Chem. 63: 1986-1994, 1998. |
| |
| Ueno, Y., Mikawa, M. and Matsuda, A.: Nucleosides and Nucleotides. 170. Synthesis
and properties of oligodeoxynucleotides containing 5-[N-[2-[N,N-bis(2-aminoethyl)amino]ethyl]carbamoyl]-2′-deoxyuridine
and 5-[N-[3-[N,N-bis(3-aminopropyl)amino]propyl]carbamoyl]-2′-deoxyuridine.
Bioconjugate Chem. 9: 33-39, 1998. |
| |
| Ueno, Y., Kanazaki, M., Shuto, S., Kim, H.-S., Wataya, Y. and Matsuda, A.: Synthesis
of oligodeoxynucleotides containing 4′α-C-aminoalkylthymidines and their
thermal stability and nuclease-resistance properties. Nucleic Acids Sympo.
Ser. 39: 13-14, 1998. |
| |
| 1997 |
| Ueno, Y., Mikawa, M. and Matsuda, A.: Nucleosides and Nucleotides. 171. Thermal
and nuclease stabilities of G-quadruplexes consisting of oligodeoxynucleotides
containing 5-[N-[2-[N,N-bis(2-aminoethyl)amino]ethyl]carbamoyl]-2′-deoxyuridine
or 5-[N-[3-[N,N-bis(3-aminopropyl)amino]propyl]carbamoyl]-2′-deoxyuridine.
Bioorg. Med. Chem. Lett. 7: 2863-2866, 1997. |
| |
| Ueno, Y., Kumagai, I., Haginoya, N. and Matsuda, A.: Effects of 5-(N-aminohexyl)carbamoyl-2′-deoxyuridine
on endonuclease stability and the ability of oligodeoxynucleotide to activate
RNase H. Nucleic Acids Res. 25: 3777-3782, 1997. |
| |
| Nomura, Y., Ueno, Y. and Matsuda, A.: Site-specific introduction of functional groups into phosphodiester oligodeoxynucleotides and their thermal stability and nuclease-resistance properties. Nucleic Acids Res. 25: 2784-2791, 1997. |
| |
| Haginoya, N., Ono, A., Nomura, Y., Ueno, Y. and Matsuda, A.: Nucleosides and Nucleotides. 160. Synthesis of oligodeoxyribonucleotides
containing 5-(N-aminoalkyl)carbamoyl-2′-deoxyuridines by a new post-synthetic
modification method and their thermal stability and nuclease-resistance
properties. Bioconjugate Chem. 8: 271-280, 1997. |
| |
| Chatake, T., Toyoda, T., Tsunoda, M., Sunami, T., Ono, A., Ueno, Y., Matsuda, A. and Takenaka, A.: X-Ray analysis of DNA dodecamer containing
2′-deoxy-N6-methoxyadenosine. Nucleic Acids Sympo. Ser. 37: 97-98, 1997. |
| |
| Kojima, N., Ueno, Y., Minakawa, N. and Matsuda, A.: Synthesis and incorporation of tricyclic-imidazo[5′,4′:4,5]pyrido[2,3-d]pyrimidine nucleosides into oligonucleotides and their thermal stability. Nucleic Acids Sympo. Ser. 37: 23-24, 1997. |
| |
| 1996 |
| Ueno, Y., Ogawa, A., Nakagawa, A. and Matsuda, A.: Nucleosides and Nucleotides. 162. Facile synthesis of 5′-5′-linked oligodeoxyribonucleotides with the potential for triple-helix formation. Bioorg. Med. Chem. Lett. 6: 2817-2822, 1996. |
| |
| Nomura, Y., Haginoya, N., Ueno, Y. and Matsuda, A.: Nucleosides and Nucleotides. 161. Incorporation of 5-(N-aminoalkyl)carbamoyl-2′-deoxycytidines
into oligodeoxyribonucleotides by a convenient post-synthetic modification
method. Bioorg. Med. Chem. Lett. 6: 2811-2816, 1996. |
| |
| Shuto, S., Ono, S., Hase, Y., Ueno, Y., Noguchi, T., Yoshii, K. and Matsuda, A.: Synthesis and biological activity
of conformationally restricted analogs of milnacipran: (1S,2R)-1-Phenyl-2-[(S)-1-aminopropyl]-N,N-diethylcyclopropanecarboxamide,
an efficient noncompetitive N-methyl-D-aspartic acid receptor antagonist.
J. Med. Chem. 39: 4844-4852, 1996. |
| |
| Aoyagi, M., Ueno, Y., Ono, A. and Matsuda, A.: Nucleosides and Nucleotides. 153. Effects of 2′-α- and 2′-β-bromo-2′-deoxyadenosine on oligonucleotide hybridization and nuclease stability. Bioorg. Med. Chem. Lett. 6: 1573-1576, 1996. |
| |
| Kakefuda, A., Masuda, A., Ueno, Y., Ono, A. and Matsuda, A.: Nucleosides and Nucleotides. 147. Synthesis
of DNA dodecamers containing oxetanocin A and (2R,3R)-2-C-(adenin-9-yl)-1,4-anhydro-2,3-dideoxy-3-C-hydroxymethyl-D-arabitol.
Tetrahedron 52: 2863-2876, 1996. |
| |
| 1995 |
| Ueno, Y., Makino, S., Kitagawa, M., Nishimura, S., Taya, Y. and Hata, T.: Chemical
synthesis of phosphopeptides using the arylthio groups for protection of
phosphate: application to identification of cdc2 kinase phosphorylation
sites. Int. J. Pept. Protein Res. 46: 106-112, 1995. |
| |
| Ueno, Y., Suda, F., Taya, Y., Noyori, R., Hayakawa, Y. and Hata, T.: Solid-phase
synthesis of peptides containing O-phosphoryl serine and O-phosphoryl threonine
using allyl group for phosphate protection. Bioorg. Med. Chem. Lett. 5:
823-826, 1995. |
| |
| Shirato, M., Shuto, S., Ueno, Y. and Matsuda, A.: Synthetic study on carbocyclic analogs of cyclic ADP-ribose. Nucleic Acids Sympo. Ser. 34: 165-166, 1995. |
| |
| 1994 |
| Sakairi, N., Takahashi, S., Wang, F., Ueno, Y. and Kuzuhara, H.: Facile preparation of 1,6-anhydro-2-azido-3-O-benzyl-2-deoxy-β-D-glucopyranose and its 4-O-substituted derivatives. Bull. Chem. Soc. Jpn. 67: 1756-1758, 1994. |
| |
| 1993 |
| Ueno, Y., Saito, R. and Hata, T.: Studies on the synthesis of nucleotidyl-peptides. II. The preparation of a nucleotidyl-peptide having a 5′-nucleotidyl-(P-O)-serine phosphodiester bond. Nucleic Acids Res. 21: 4451-4457, 1993. |
| |
| Makino, S., Ueno, Y., Ishikawa, M., Hayakawa, Y. and Hata, T.: Chemical synthesis of cytidine-5′-monophosphono-N-acetylneuraminic
acid (CMP-Neu5Ac). Tetrahedron Lett. 34: 2775-2778, 1993. |
| |
| 1992 |
| Ueno, Y., Mishima, T., Hotoda, H. and Hata, T.: Synthesis of 2′(3′)-O-(L-phenylalanyl)-
and 2′(3′)-O-(D-phenylalanyl)cytidylyl(3′-5′)adenosine. Chem. Lett.: 595-598,
1992. |
| |
| 1991 |
| Ueno, Y., Saito, R. and Hata, T.: Preparation of O-phosphoryl amino acid building blocks for the synthesis of O-phosphoryl peptides. Tetrahedron Lett. 32: 1347-1350, 1991. |
|
| Ueno, Y., Saito, R., Hotoda, H. and Hata, T.: Chemical synthesis of the nucleotidyl
peptides. Nucleic Acids Sympo. Ser. 25: 61-62, 1991. |
| |
| 1989 |
| Hotoda, H., Ueno, Y., Sekine, M. and Hata, T.: Studies on the synthesis of nucleotidyl-peptide.
I. A facile synthesis involving selective phosphorus-sulfur bond cleavage.
Tetrahedron Lett. 30: 2117-2120, 1989. |
| |
| |
|
|
|
