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Laboratory of Veterinary Pharmacology, Basic Veterinary Medicine, Joint Department of Veterinary Madicine, Faculty of Applied Biological Siences, GIFU Univercity

研究成果RESULTS


発表論文

2009年

Unno,T., Iida, R., Okawa, M., Matsuyama, H., Hossain, M,M., Kobayashi, H., Komori, S.
Tributyltin-induced Ca2+ mobilization via L-type voltage-dependent Ca2+ channels in PC12 cells.
Environ. Toxicol. Pharmacol. 28: 70-77, 2009.


Kitazawa, T., Asakawa, K., Nakamura, T., Teraoka, H., Unno, T., Komori, S., Yamada, M., Wess, J.: M3 muscarinic receptors mediate positive inotropic responses in mouse atria: a study with muscarinic receptor knockout mice. J. Pharmacol. Exp. Ther. 330: 487-493, 2009.

tanahashi, Y., Unno, T., Matsuyama, H., Ishii, T., Yamada, M., Wess, J., Komori, S.: Multiple muscarinic pathways mediate the suppression of voltage-gated Ca2+ channels in mouse intestinal smooth muscle cells. Br. J. Pharmacol. (in press) 2009.

2008年
Hossain, M.M., Suzuki, T., Unno, T., Komori, S., Kobayashi, H.: Differential presynaptic actions of pyrethroid insecticides on glutamatergic and GABAergic neurons in the hippocampus. Toxicol. 243: 155-163, 2008.

Kitazawa, T., Hirama, R., Masunaga, K., Nakamura, T., Asakawa, K., Cao, J., Teraoka, H., Unno, T., Komori, S., Yamada, M., Wess, J., Taneike, T.: Muscarinic receptor subtypes involved in carbachol-induced contraction of mouse uterine smooth muscle. Naunyn Schmiedebergs Arch. Pharmacol. 377: 503-513, 2008.


Sakamoto, T., Matsuyama, H., Yamamoto, M., Tanahashi, Y., Kitazawa, T., Taneike, T., Komori, S., Unno, T.: A non-selective cationic channel activated by diacylglycerol in mouse intestinal myocytes. Eur. J. Pharmacol. 599: 54-57, 2008.

Yamamoto, M., Unno, T., Matsuyama, H., Kohda, M., Masuda, N., Nishimura, M., Ishii, T., Komori, S.: Two types of cation channel activated by stimulation of muscarinic receptors in guinea-pig urinary bladder smooth muscle. J. Pharmacol. Sci. 108: 248-257, 2008.

Fujikawa, R., Ishii, T., Komori, S., Nishimura, M.: Improved calcium utilization at motor nerve terminals exposed to botulinum neurotoxin in mice. J. Physiol. Sci. 58: 419-424, 2008.

Matsuyama, H., Nguyen, T.V., Hunne, B., Thacker, M., Needham, K., McHugh, D., Furness, J.B.: Evidence that TASK1 channels contribute to the background current in AH/type II neurons of the guinea-pig intestine. Neurosci. 155: 738-750, 2008.

da Silveira, A.B., Correa-Oliveira, R., Matsuyama, H., de Oliveira, E.C., Neto, S.G., Luquetti, A.O., Furness, J.B., d'Avila Reis, D.: Decreased expression of IK channels in neurons from enteric nervous system is associated with the development of chagasic megacolon. Hum. Pathol. 39: 1406-1407, 2008.

Shimizu, Y., Matsuyama, H., Shiina, T., Takewaki, T., Furness, J.B.: Tachykinins and their functions in the gastrointestinal tract. Cell Mol. Life Sci. 65: 295-311, 2008.

2007年
Kitazawa, T., Hashiba, K., Cao, J., Unno, T., Komori, S., Yamada, M., Wess, J. and Taneike, T.: Functional roles of muscarinic M2 and M3 receptors in mouse stomach motility: studies with muscarinic receptor knockout mice. Eur. J. Pharmacol. 554: 212-222, 2007.

Nguyen, T.V., Matsuyama, H., Baell, J., Hunne, B., Fowler, C.J., Smith, J.E., Nurgali, K. and Furness, J.B.: Effects of compounds that influence IK (KCNN4) channels on afterhyperpolarizing potentials, and determination of IK channel sequence, in guinea pig enteric neurons. J. Neurophysiol. 97: 2024-2031, 2007.

Sakamoto, T., Unno, T., Kitazawa, T., Taneike, T., Yamada, M., Wess, J., Nishimura, M. and Komori, S.: Three distinct muscarinic signaling pathways for cationic channel activation in mouse gut smooth muscle cells. J Physiol. 582: 41-61, 2007.

Nurgali, K., Nguyen, T.V., Matsuyama, H., Thacker, M., Robbins, H.L. and Furness, J.B.: Phenotypic changes of morphologically identified myenteric neurons following intestinal inflammation. J Physiol. (in press) 2007.

2006年
Sakamoto, T., Unno, T., Matsuyama, H., Uchiyama, M., Hattori, M., Nishimura, M. and Komori, S.: Characterization of muscarinic receptor-mediated cationic currents in longitudinal smooth muscle cells of mouse small intestine. J. Pharmacol. Sci. 100: 215-226, 2006.

Unno, T., Matsuyama, H., Okamoto, H., Sakamoto, T., Yamamoto, M., Tanahashi, Y., Yan, H.-D. and Komori, S.: Muscarinic cationic current in gastrointestinal smooth muscles: Signal transduction and role in contraction. Auton. Autacoid Pharmacol. 26: 203-217, 2006.
Autonomic & Autacoid Pharmacology誌の“Most Read Articles”第4位にランクされました。

Unno, T., Matsuyama, H., Izumi, Y., Yamada, M., Wess, J. and Komori, S.: Roles of M2 and M3 muscarinic receptors in cholinergic nerve-induced contractions in mouse ileum studief with receptor knockout mice. Br. J. Pharmacol. 149: 1022-1030, 2006.

Muroi, Y., Ishii, T., Komori, S., Kitamura, N. and Nishimura, M.: Volatile female odors activate the accessory olfactory system of male mice without physical contact. Neurosci. 141:551-558, 2006.


Lang, R.J., Nguyen, D.T., Matsuyama, H., Takewaki, T. and Exintaris, B.: Characterization of spontaneous depolarizations in smooth muscle cells of the Guinea pig prostate. J. Urol. 175:370-380, 2006.

2005年
Unno, T., Matsuyama, H., Sakamoto, T, Uchiyama, M., Izumi, Y., Okamoto, H., Yamada, M., Wess, J. and Komori, S.: M2 and M3 muscarinic receptor-mediated contractions in longitudinal smooth muscle of the ileum studied with receptor knockout mice. Br. J. Pharmacol. 146: 98-108, 2005.

Muroi, Y., Ishii, T., Komori, S. and Nishimura, M.: A competitive effect of androgen signaling on male mouse attraction to volatile female mouse odors. Physiol. Behav. 87:199-205, 2005.

El-Mahmoudy, A., Shimizu, Y., Shiina, T., Matsuyama, H., Nikami, H. and Takewaki, T.: Macrophage-derived cytokine and nitric oxide profiles in type I and type II diabetes mellitus: effect of thymoquinone. Acta Diabetol. 42:23-30, 2005.

El-Mahmoudy, A., Shimizu, Y., Shiina, T., Matsuyama, H., El-Sayed, M. and Takewaki, T.: Successful abrogation by thymoquinone against induction of diabetes mellitus with streptozotocin via nitric oxide inhibitory mechanism. Int Immunopharmacol. 5:195-207, 2005.


2004
Okamoto, H., Unno, T., Arima, D., Suzuki, M., Yan, H.-D., Matsuyama, H. andKomori, S.: Phospholipase C involvement in activation of the muscarinic receptor-operated cationic current in guinea pig ileal smooth muscle cells. J. Pharmacol. Sci. 95: 203-213, 2004.


2003
Unno, T., Kwon, S.-C., Okamoto, H., Irie, Y., Katoh, Y., Matsuyama, H. and Komori, S.: Receptor signaling mechanisms underlying muscarinic agonist-evoked contraction in guinea-pig ileal longitudinal smooth muscle. Br. J. Pharmacol. 139: 337-350, 2003.

Yan, H.-D., Okamoto, H., Unno, T., Tsytsyura, Ya.D., Prestwich, S.A., Komori, S., Zholos, A.V. and Bolton, T.B.: Effects of G-protein-specific antibodies and Gbg subunits on the muscarinic receptor-operated cation current in guinea-pig ileal smooth muscle cells. Br. J. Pharmacol. 139: 605-615, 2003.

Unno, T., Matsuyama, H. and Komori, S.: Interaction between the M2 and M3 receptor subtypes in muscarinic electrical and mechanical responses of intestinal smooth muscles. Neurophysiol. 35: 290-301, 2003.

Unno, T., Matsuyama, H. and Komori, S.: Muscarinic signal transduction in gastrointestinal smooth muscle. In Recent Research Development in Physiology Vol. 1 Part II, S.G. Pandalai, S. G. eds. Research Signpost, India, pp. 577-597, 2003.

Kawai, M., Nguyen, T.V., Stebbing, M.J., Clerc N., Komori, S. and Furness, J.B.: Comparison of the effects of phorbol dibutyrate and low-frequency stimulation of synaptic inputs on the excitability of myenteric AH neurons. Pflugers Arch. 447: 298-304, 2003.

Matsuyama, H., El-Mahmoudy, A., Shimizu, Y. and Takewaki, T. Nitrergic prejunctional inhibition of purinergic neuromuscular transmission in the hamster proximal colon. J Neurophysiol. 89:2346-2353, 2003.

El-Mahmoudy, A., Matsuyama, H., Khalifa, M., Shimizu, Y. and Takewaki, T.: Tachykinins mediate non-adrenergic, non-cholinergic excitatory neurotransmission to the hamster ileum via NK1 and NK2 receptors. Life Sci. 73:1939-1951, 2003.

Izumi, N., Matsuyama, H., Ko, M., Shimizu, Y. and Takewaki, T.: Role of intrinsic nitrergic neurones on vagally mediated striated muscle contractions in the hamster oesophagus. J Physiol. 551:287-294, 2003.

Thapaliya, S., Matsuyama, H., El-Mahmoudy, A., Shimizu, Y. and Takewaki, T.: An endothelium-derived factor modulates purinergic neurotransmission to mesenteric arterial smooth muscle of hamster. Eur J Pharmacol. 461:129-137, 2003.

2002
Matsuyama, H., Unno, T., El-Mahmoudy, A. M., Komori, S., Kobayashi, H., Thapaliya, S. and Takewaki, T.: Peptidergic and nitrergic inhibitory neurotransmissions in the hamster jejunum: regulation of vasoactive intestinal peptide release by nitric oxide. Neurosci. 110: 779-788, 2002.

Unno, T., Inaba, Y., Ohashi, H. and Komori, S.: Inhibitory effects of organotin compounds on voltage-dependent, tetrodotoxin-resistant Na+ channel current in guinea pig dorsal root ganglion cells. Toxicol. in Vitro 16: 141-150, 2002.

Okamoto, H., Prestwich, S. A., Asai, S., Unno, T., Bolton, T. B. and Komori, S.: Muscarinic agonist potencies at three different effector systems linked to the M2 and M3 receptor in longitudinal smooth muscle of guinea-pig small intestine. Br. J. Pharmacol. 135: 1765-1775, 2002.

Saito, H., Thapaliya, S., Matsuyama, H., Nishimura, M., Unno, T., Komori, S. and Takewaki, T.: Reversible impairment of endothelium-dependent relaxation in golden hamster carotid arteries during hibernation. J. Physiol. 540: 285-294, 2002.

海野年弘, 稲葉裕次, 小森成一: 環境における毒物−有機スズ化合物による神経毒性−. Jpn. J. Zoo Wildl. Med. 7: 53-59, 2002.

Izumi, N., Matsuyama, H., Yamamoto, Y., Atoji, Y., Suzuki, Y., Unno, T. and Takewaki, T.: Morphological and morphometrical characteristics of the esophageal intrinsic nervous system in the golden hamster. Eur. J. Morphol. 40: 137-144, 2002.

2001
Kitoh, K., Oka, A., Kitagawa, H., Unno, T., Komori, S. and Sasaki, Y.: Relaxing and contracting activities of heartworm extract on isolated canine abdominal aorta. J. Parastol. 87: 522-526 2001.

2000
Kawarada, S., Unno, T., Ohash, H. and Komori, S.: Neurotensin-induced Cl- current in guinea-pig dorsal root ganglion cells. Eur. J. Pharmacol. 404: 69-78, 2000.


Iwata, M., Unno, T., Minamoto, N., Ohashi, H. and Komori, S.: Rabies virus infection prevents the modulation by a2-adrenoceptors, but not muscarinic receptors, of Ca2+ channels in NG108-15 cells. Eur. J. Pharmacol. 404: 79-88, 2000.

Unno, T., Inaba, T., Ohashi, H., Takewaki, T. and Komori, S.: Role of Ca2+ mobilization in muscarinic receptor-mediated membrane depolarization in guinea pig ileal smooth muscle cells. Jpn. J. Pharmacol. 84: 431-437, 2000.

Oda, A., Ohashi, H., Komori, S., Iida, H., Dohi, S.: Characteristics of ropivacaine block of Na+ channels in rat dorsal root ganglion neurons. Anesth Analg. 91:1213-1220, 2000

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