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研究

研究内容

サーベイランス等で得られた病原細菌の薬剤感受性、薬剤耐性機構、病原因子等の解析や検出系の開発・評価を行う。

研究成果

2017
  • Yasuda M, Hatazaki K, Ito S, Kitanohara M, Yoh M, Kijima M, Narita H, Kido A, Miyata K, Deguchi T: Antimicrobial Susceptibility of Neisseria gonorrhoeae in Japan from 2000 to 2015. Sex Transm Dis. 44, 149-153, 2017.
2016
  • Deguchi T, Yasuda M, Hatazaki K, Kameyama K, Horie K, Kato T, Mizutani K, Seike K, Tsuchiya T, Yokoi S, Nakano M, Yoh M: New Clinical Strain of Neisseria gonorrhoeae with Decreased Susceptibility to Ceftriaxone, Japan. Emerg Infect Dis. 22, 142-144, 2016
  • Seike K, Yasuda M, Hatazaki K, Mizutani K, Yuhara K, Ito Y, Fujimoto Y, Ito S, Tsuchiya T, Yokoi S, Nakano M, Deguchi T: Novel penA mutations identified in Neisseria gonorrhoeae with decreased susceptibility to ceftriaxone isolated
    between 2000 and 2014 in Japan. J Antimicrob Chemother. 71, 2466-2470, 2016
  • Ito S, Yasuda M, Hatazaki K, Mizutani K, Tsuchiya T, Yokoi S, Nakano M, Deguchi T: Microbiological efficacy and tolerability of a single-dose regimen of ceftriaxone 1 g in men with gonococcal urethritis. J Antimicrob Chemother. 71, 2559-2562, 2016
  • Yasuda M, Ito S, Hatazaki K, Deguchi T: Remarkable increase of Neisseria gonorrhoeae with decreased susceptibility of azithromycin and increase in the failure of azithromycin therapy in male gonococcal urethritis in Sendai in 2015. J Infect Chemother. 22, 841-843, 2016
2014
  • Deguchi T, Yasuda M, Tsuchiya T, Yokoi S, Ito S: Decreased susceptibility to cephalosporins among gonococci? Lancet Infect Dis. 14, 185-186, 2014
  • Yasuda M, Ito S, Kido A, Hamano K, Uchijima Y, Uwatoko N, Kusuyama H, Watanabe A, Miyamura R, Miyata K, Deguchi T: A single 2 g oral dose of extended-release azithromycin for treatment of gonococcal urethritis. J Antimicrob Chemother. 69, 3116-3118, 2014
2012
  • Deguchi T, Yasuda M, Ito S: Management of pharyngeal gonorrhea is crucial to prevent the emergence and spread of antibiotic-resistant Neisseria gonorrhoeae. Antimicrob Agents Ch. 56, 4039-4040, 2012
2011
  • Deguchi T, Seike K, Yasuda M, Matsumoto T: Evaluation by Monte Carlo simulation of levofloxacin dosing for complicated urinary tract infections caused by Escherichia coli or Pseudomonas aeruginosa. J Infect Chemother. 17, 726-730, 2011
2008
  • Ochiai S, Ishiko H, Yasuda M, Deguchi T: Rapid detection of the mosaic structure of the Neisseria gonorrhoeae penA Gene, which is associated with decreased susceptibilities to oral cephalosporins. J Clin Microbiol. 46, 1804-1810, 2008
2007
  • Yokoi S, Deguchi T, Ozawa T, Yasuda M, Ito S, Kubota Y, Tamaki M, Maeda S: Threat to cefixime treatment for gonorrhea. Emerg Infect Dis. 13, 1275-1277, 2007
2005
  • Ito M, Deguchi T, Mizutani K, Yasuda M, Yokio S, Ito S, Takahashi Y, Ishihara S, Kawamura Y, Ezaki T: Emergence and spread of Neisseria gonorrhoeae clinical isolates harboring mosaic-like structure of penicillin-binding protein 2 in central Japan. Antimicrob Agent Chemother. 49, 137-143, 2005
2004
  • Ito M, Yasuda M, Yokoi S, Ito S, Takahashi Y, Ishihara S, Maeda S, Deguchi T: Remarkable increase in central Japan in 2001-2002 of Neisseria gonorrhoeae isolates with decreased susceptibility to penicillin, tetracycline, oral cephalosporins, and fluoroquinolones. Antimicrob Agents Chemother. 48, 3185-3187, 2004
2002
  • Ishihara S, Yokoi, S, Masue N, Yamada T, Minamidate Y, Yasuda M, Nakano M, Deguchi T: Urinary tract-derived Escherichia coli resistant to co-trimoxazole in Japan, where the drug is seldom used for treating acute urinary tract infections. J Antimicrob Chemother. 49, 881-882, 2002
  • Ishihara S, Yamada T, Yokoi S, Ito M, Yasuda M, Nakano M, Kawada Y, Deguchi T: Antimicrobial activity of imipenem against isolates from complicated urinary tract infections. Int J Antimicrob Agents. 19, 565-569, 2002
2001
  • Nakano M, Yasuda M, Yokoi S, Takahashi Y, Ishihara S, Deguchi T: In vivo selection of Pseudomonas aeruginosa with decreased susceptibilities to fluoroquinolones during fluoroquinolone treatment of urinary tract infection. Urology. 58, 125-128, 2001
2000
  • Yasuda M, Fukuda H, Yokoi S, Ishihara S, Kawada Y, Deguchi T: In vitro selection of fluoroquinolone-resistant Neisseria gonorrhoeae harboring alterations in DNA gyrase and topoisomerase IV.J Urol. 164, 847-851, 2000
  • Deguchi T, Yamaha M, Nakano M, Yasuda M, Nishino Y, Ishihara S, Kawada Y: Development of a rapid assay for screening point mutations associated with quinolone resistance in the Pseudomonas aeruginosa parC gene. J Infect Chemother. 6, 26-29, 2000
1998
  • Kanematsu E, Deguchi T, Yasuda M, Kawamura T, NishinoY, Kawada Y: Alterations in the GyrA subunit of DNA gyrase and the ParC subunit of DNA topoisomerase IV associated with quinolone resistance in Enterococcus faecalis. Antimicrob Agents Chemother. 42, 433-435, 1998
  • Deguchi T, Yasuda M, Maeda S, Saito I, Kawada Y: Serotyping of quinolone-resistant Neisseria gonorrhoeae isolates with alterations in GyrA and ParC. J Antimicrob Chemother. 41, 418-420, 1998
  • Li Z, Deguchi T, Yasuda M, Kawamura T, Kanematsu E, Nishino Y, Ishihara S, Kawada Y: Alteration in the GyrA subunit of DNA gyrase and the ParC subunit of DNA topoisomerase IV in quinolone-resistant clinical isolates of Staphylococcus epidermidis. Antimicrob Agents Chemother. 42, 3293-3295, 1998
  • Ishihara S, Yasuda M, Nakano M, Ozeki S, Deguchi T, Ban Y, Kawada Y: The significance of Stenotrophomonas maltophilia in urinary tract infection. J Infect Chemother. 4, 20-23, 1998
  • Nakano M, Deguchi T, Yasuda M, Ozeki S, Nishino Y, Ishihara S, Kawada Y: Antimicrobial activity of a new fluoroquinolone, DU-6859a, against quinolone-resistant clinical isolates of Pseudomonas aeruginosa with genetic alterations in the GyrA subunit of DNA gyrase and the parC subunit of topoisomerase Ⅳ.J Infect Chemother. 4, 142-144, 1998
1997
  • Deguchi T, Yasuda M, Nakano M, Kanematsu E, Ozeki S, Ishihara S, Saito I, Kawada Y: Antimicrobial activity of a new fluoroquinolone, DU-6859a, against quinolone-resistant clinical isolates of Neisseria gonorrhoeae with genetic alterations in the GyrA subunit of DNA gyrase and the ParC subunit of topoisomerase IV. J Antimicrob Chemother. 39, 247-249, 1997
  • Deguchi T, Yasuda M, Nakano M, Kanematsu E, Ozeki S, Nishino Y, Ezaki T, Maeda S, Saito I, Kawada Y: Rapid screening of point mutations of the Neisseria gonorrhoeae parC gene associated with resistance to quinolones. J Clin Microbiol. 35, 948-950, 1997
  • Deguchi T, Saito I, Tanaka M, Sato K-I, Deguchi K-I, Yasuda M, Nakano M, Nishino Y, Kanematsu E, Ozeki S, Kawada Y: Fluoroquinolone treatment failure in gonorrhea. Emergence of a Neisseria gonorrhoeae strain with enhanced resistance to fluoroquinolones. Sex Transm Dis. 24, 247-50, 1997
  • Deguchi T, Yasuda M, Nakano M, Ozeki S, Kanematsu E, Fukuda H, Maeda S, Kawada Y: Comparison of in vitro antimicrobial activity of AM-1155 with those of tosufloxacin and fleroxacin against clinical isolates of Neisseria gonorrhoeae harboring quinolone resistance alterations in GyrA and ParC. Chemotherapy. 43, 239-244, 1997
  • Deguchi T, Yasuda M, Ishihara S, Takahashi Y, Okezaki E, Nagata O, Saito I, Kawada Y: In-vitro antimicrobial activity of HSR-903, a new fluoroquinolone, against clinical isolates of Neisseria gonorrhoeae with quinolone resistance-associated alterations in GyrA and ParC. J Antimicrob Chemother. 40, 437-439, 1997
  • Deguchi T, Fukuoka A, Yasuda M, Nakano M, Ozeki S, Kanematsu E, Nishino Y, Ishihara S, Ban Y, Kawada Y: Alterations in the GyrA subunit of DNA gyrase and the ParC subunit of topoisomerase IV in quinolone-resistant clinical isolates of Klebsiella pneumoniae. Antimicrob Agents Chemother. 41, 699-701, 1997
  • Deguchi T, Kawamura T, Yasuda M, Nakano M, Fukuda H, Kato H, Kato N, Okano Y, Kawada Y: In vivo selection of Klebsiella pneumoniae strains with enhanced quinolone resistance during fluoroquinolone treatment of urinary tract infections. Antimicrob Agents Chemother. 41, 1609-1611, 1997
  • Ozeki S, Deguchi T, Yasuda M, Nakano M, Kawamura T, Nishino Y, Kawada Y: Development of a rapid assay for detecting gyrA mutations in Escherichia coli and determination of incidence of gyrA mutations in clinical strains isolated from patients with complicated urinary tract infections. J Clin Microbiol. 35, 2315-2319, 1997
  • Nishino Y, Deguchi T, Yasuda M, Kawamura T, Nakano M, Kanematsu E, Ozeki S, Kawada Y: Mutations in the gyrA and parC genes associated with fluoroquinolone resistance in clinical isolates of Citrobacter freundii. FEMS Microbiol Lett. 15, 409-414, 1997
  • Nakano M, Deguchi T, Kawamura T, Yasuda M, Kimura M, Okano Y, Kawada Y: Mutations in the gyrA and parC genes in fluoroquinolone-resistant clinical isolates of Pseudomonas aeruginosa. Antimicrob Agents Chemother. 41, 2289-2291, 1997
  • Deguchi T, Yasuda M, Kawamura T, Nakano M, Ozeki S, Kanematsu E, Nishino Y, Kawada Y: Improved antimicrobial activity of DU-6859a, a new fluoroquinolone, against quinolone-resistant Klebsiella pneumoniae and Enterobacter cloacae isolates with alterations in GyrA and ParC proteins. Antimicrob Agents Chemother. 41, 2544-2546, 1997
  • Deguchi T, Yasuda M, Nakano M, Ozeki S, Kanematsu E, Nishino Y, Ishihara S, Kawada Y: Detection of mutations in the gyrA and parC genes in quinolone-resistant clinical isolates of Enterobacter cloacae. J Antimicrob Chemother. 40, 543-549, 1997
  • Deguchi T, Yasuda M, Kawamura T, Takahashi Y, Okezaki E, Nagata O, Kato H, Kawada Y: In-vitro antimicrobial activity of HSR-903, a new fluoroquinolone, against clinical isolates of Klebsiella pneumoniae and Enterobacter cloacae with fluoroquinolone resistance-associated amino acid alterations in GyrA and ParC. J Antimicrob Chemother. 40, 907-909, 1997
1996
  • Deguchi T, Yasuda M, Nakano M, Ozeki S, Ezaki T, Saito I, Kawada Y:Quinolone-resistant Neisseria gonorrhoeae: correlation of alterations in the GyrA subunit of DNA gyrase and the ParC subunit of topoisomerase IV with antimicrobial susceptibility profiles. Antimicrob Agents Chemother. 40, 1020-1023, 1996
  • Deguchi T, Yasuda M, Nakano M, Ozeki S, Ezaki T, Maeda S, Saito I, Kawada Y: Rapid detection of point mutations of the Neisseria gonorrhoeae gyrA gene associated with decreased susceptibilities to quinolones. J Clin Microbiol. 34, 2255-2258, 1996
  • Deguchi T, Yasuda M, Nakano M, Ozeki S, Kanematsu E, Kawada Y, Ezaki T, Saito I: Uncommon occurrence of mutations in the gyrB gene associated with quinolone resistance in clinical isolates of Neisseria gonorrhoeae. Antimicrob Agents Chemother. 40, 2437-2438, 1996
1995
  • Deguchi T, Yasuda M, Asano M, Tada K, Iwata H, Komeda H, Ezaki T, Saito I, Kawada Y:DNA gyrase mutations in quinolone-resistant clinical isolates of Neisseria gonorrhoeae. Antimicrob Agents Chemother. 39, 561-563, 1995