研究成果RESULTS
発表論文
2009年
Unno,T., Iida, R., Okawa, M., Matsuyama, H., Hossain, M,M., Kobayashi,
H., Komori, S.
Tributyltin-induced Ca2+ mobilization via L-type voltage-dependent Ca2+ channels in PC12 cells.
Environ. Toxicol. Pharmacol. 28: 70-77, 2009.
Kitazawa, T., Asakawa, K., Nakamura, T., Teraoka, H., Unno, T., Komori, S., Yamada, M., Wess, J.: M3 muscarinic receptors mediate positive inotropic responses in mouse atria: a study with muscarinic receptor knockout mice. J. Pharmacol. Exp. Ther. 330: 487-493, 2009.
tanahashi, Y., Unno, T., Matsuyama, H., Ishii, T., Yamada, M., Wess, J.,
Komori, S.: Multiple muscarinic pathways mediate the suppression of voltage-gated Ca2+ channels in mouse intestinal smooth muscle cells. Br. J. Pharmacol. (in press) 2009.
2008年
Hossain, M.M., Suzuki, T., Unno, T., Komori, S., Kobayashi, H.: Differential presynaptic actions of pyrethroid insecticides on glutamatergic and GABAergic neurons in the hippocampus. Toxicol. 243: 155-163, 2008.
Kitazawa, T., Hirama, R., Masunaga, K., Nakamura, T., Asakawa, K., Cao, J., Teraoka, H., Unno, T., Komori, S., Yamada, M., Wess, J., Taneike, T.: Muscarinic receptor subtypes involved in carbachol-induced contraction of mouse uterine smooth muscle. Naunyn Schmiedebergs Arch. Pharmacol. 377: 503-513, 2008.
Sakamoto, T., Matsuyama, H., Yamamoto, M., Tanahashi, Y., Kitazawa, T., Taneike, T., Komori, S., Unno, T.: A non-selective cationic channel activated by diacylglycerol in mouse intestinal myocytes. Eur. J. Pharmacol. 599: 54-57, 2008.
Yamamoto, M., Unno, T., Matsuyama, H., Kohda, M., Masuda, N., Nishimura, M., Ishii, T., Komori, S.: Two types of cation channel activated by stimulation of muscarinic receptors in guinea-pig urinary bladder smooth muscle. J. Pharmacol. Sci. 108: 248-257, 2008.
Fujikawa, R., Ishii, T., Komori, S., Nishimura, M.: Improved calcium utilization at motor nerve terminals exposed to botulinum neurotoxin in mice. J. Physiol. Sci. 58: 419-424, 2008.
Matsuyama, H., Nguyen, T.V., Hunne, B., Thacker, M., Needham, K., McHugh, D., Furness, J.B.: Evidence that TASK1 channels contribute to the background current in AH/type II neurons of the guinea-pig intestine. Neurosci. 155: 738-750, 2008.
da Silveira, A.B., Correa-Oliveira, R., Matsuyama, H., de Oliveira, E.C., Neto, S.G., Luquetti, A.O., Furness, J.B., d'Avila Reis, D.: Decreased expression of IK channels in neurons from enteric nervous system is associated with the development of chagasic megacolon. Hum. Pathol. 39: 1406-1407, 2008.
Shimizu, Y., Matsuyama, H., Shiina, T., Takewaki, T., Furness, J.B.: Tachykinins and their functions in the gastrointestinal tract. Cell Mol. Life Sci. 65: 295-311, 2008.
2007年
Kitazawa, T., Hashiba, K., Cao, J., Unno, T., Komori, S., Yamada, M., Wess, J. and Taneike, T.: Functional roles of muscarinic M2 and M3 receptors in mouse stomach motility: studies with muscarinic receptor knockout mice. Eur. J. Pharmacol. 554: 212-222, 2007.
Nguyen, T.V., Matsuyama, H., Baell, J., Hunne, B., Fowler, C.J., Smith,
J.E., Nurgali, K. and Furness, J.B.: Effects of compounds that influence
IK (KCNN4) channels on afterhyperpolarizing potentials, and determination
of IK channel sequence, in guinea pig enteric neurons. J. Neurophysiol.
97: 2024-2031, 2007.
Sakamoto, T., Unno, T., Kitazawa, T., Taneike, T., Yamada, M., Wess, J., Nishimura, M. and Komori, S.: Three distinct muscarinic signaling pathways for cationic channel activation in mouse gut smooth muscle cells. J Physiol. 582: 41-61, 2007.
Nurgali, K., Nguyen, T.V., Matsuyama, H., Thacker, M., Robbins, H.L. and
Furness, J.B.: Phenotypic changes of morphologically identified myenteric
neurons following intestinal inflammation. J Physiol. (in press) 2007.
2006年
Sakamoto, T., Unno, T., Matsuyama, H., Uchiyama, M., Hattori, M., Nishimura, M. and Komori, S.: Characterization of muscarinic receptor-mediated cationic currents in longitudinal smooth muscle cells of mouse small intestine. J. Pharmacol. Sci. 100: 215-226, 2006.
Unno, T., Matsuyama, H., Okamoto, H., Sakamoto, T., Yamamoto, M., Tanahashi,
Y., Yan, H.-D. and Komori, S.: Muscarinic cationic current in gastrointestinal
smooth muscles: Signal transduction and role in contraction. Auton. Autacoid
Pharmacol. 26: 203-217, 2006.
→Autonomic & Autacoid Pharmacology誌の“Most Read Articles”第4位にランクされました。
Unno, T., Matsuyama, H., Izumi, Y., Yamada, M., Wess, J. and Komori, S.:
Roles of M2 and M3 muscarinic receptors in cholinergic nerve-induced contractions in mouse ileum studief with receptor knockout mice. Br. J. Pharmacol. 149: 1022-1030, 2006.
Muroi, Y., Ishii, T., Komori, S., Kitamura, N. and Nishimura, M.: Volatile female odors activate the accessory olfactory system of male mice without physical contact. Neurosci. 141:551-558, 2006.
Lang, R.J., Nguyen, D.T., Matsuyama, H., Takewaki, T. and Exintaris, B.:
Characterization of spontaneous depolarizations in smooth muscle cells
of the Guinea pig prostate. J. Urol. 175:370-380, 2006.
2005年
Unno, T., Matsuyama, H., Sakamoto, T, Uchiyama, M., Izumi, Y., Okamoto, H., Yamada, M., Wess, J. and Komori, S.: M2 and M3 muscarinic receptor-mediated contractions in longitudinal smooth muscle of the ileum studied with receptor knockout mice. Br. J. Pharmacol. 146: 98-108, 2005.
Muroi, Y., Ishii, T., Komori, S. and Nishimura, M.: A competitive effect of androgen signaling on male mouse attraction to volatile female mouse odors. Physiol. Behav. 87:199-205, 2005.
El-Mahmoudy, A., Shimizu, Y., Shiina, T., Matsuyama, H., Nikami, H. and
Takewaki, T.: Macrophage-derived cytokine and nitric oxide profiles in
type I and type II diabetes mellitus: effect of thymoquinone. Acta Diabetol.
42:23-30, 2005.
El-Mahmoudy, A., Shimizu, Y., Shiina, T., Matsuyama, H., El-Sayed, M. and
Takewaki, T.: Successful abrogation by thymoquinone against induction of
diabetes mellitus with streptozotocin via nitric oxide inhibitory mechanism.
Int Immunopharmacol. 5:195-207, 2005.
2004年
Okamoto, H., Unno, T., Arima, D., Suzuki, M., Yan, H.-D., Matsuyama, H.
andKomori, S.: Phospholipase C involvement in activation of the muscarinic
receptor-operated cationic current in guinea pig ileal smooth muscle cells.
J. Pharmacol. Sci. 95: 203-213, 2004.
2003年
Unno, T., Kwon, S.-C., Okamoto, H., Irie, Y., Katoh, Y., Matsuyama, H. and Komori, S.: Receptor signaling mechanisms underlying muscarinic agonist-evoked contraction in guinea-pig ileal longitudinal smooth muscle. Br. J. Pharmacol. 139: 337-350, 2003.
Yan, H.-D., Okamoto, H., Unno, T., Tsytsyura, Ya.D., Prestwich, S.A., Komori, S., Zholos, A.V. and Bolton, T.B.: Effects of G-protein-specific antibodies and Gbg subunits on the muscarinic receptor-operated cation current in guinea-pig ileal smooth muscle cells. Br. J. Pharmacol. 139: 605-615, 2003.
Unno, T., Matsuyama, H. and Komori, S.: Interaction between the M2 and M3 receptor subtypes in muscarinic electrical and mechanical responses of
intestinal smooth muscles. Neurophysiol. 35: 290-301, 2003.
Unno, T., Matsuyama, H. and Komori, S.: Muscarinic signal transduction in gastrointestinal smooth muscle. In Recent
Research Development in Physiology Vol. 1 Part II, S.G. Pandalai, S. G.
eds. Research Signpost, India, pp. 577-597, 2003.
Kawai, M., Nguyen, T.V., Stebbing, M.J., Clerc N., Komori, S. and Furness,
J.B.: Comparison of the effects of phorbol dibutyrate and low-frequency
stimulation of synaptic inputs on the excitability of myenteric AH neurons.
Pflugers Arch. 447: 298-304, 2003.
Matsuyama, H., El-Mahmoudy, A., Shimizu, Y. and Takewaki, T. Nitrergic
prejunctional inhibition of purinergic neuromuscular transmission in the
hamster proximal colon. J Neurophysiol. 89:2346-2353, 2003.
El-Mahmoudy, A., Matsuyama, H., Khalifa, M., Shimizu, Y. and Takewaki,
T.: Tachykinins mediate non-adrenergic, non-cholinergic excitatory neurotransmission
to the hamster ileum via NK1 and NK2 receptors. Life Sci. 73:1939-1951,
2003.
Izumi, N., Matsuyama, H., Ko, M., Shimizu, Y. and Takewaki, T.: Role of
intrinsic nitrergic neurones on vagally mediated striated muscle contractions
in the hamster oesophagus. J Physiol. 551:287-294, 2003.
Thapaliya, S., Matsuyama, H., El-Mahmoudy, A., Shimizu, Y. and Takewaki, T.: An endothelium-derived factor modulates purinergic neurotransmission to mesenteric arterial smooth muscle of hamster. Eur J Pharmacol. 461:129-137, 2003.
2002年
Matsuyama, H., Unno, T., El-Mahmoudy, A. M., Komori, S., Kobayashi, H.,
Thapaliya, S. and Takewaki, T.: Peptidergic and nitrergic inhibitory neurotransmissions
in the hamster jejunum: regulation of vasoactive intestinal peptide release
by nitric oxide. Neurosci. 110: 779-788, 2002.
Unno, T., Inaba, Y., Ohashi, H. and Komori, S.: Inhibitory effects of organotin compounds on voltage-dependent, tetrodotoxin-resistant Na+ channel current in guinea pig dorsal root ganglion cells. Toxicol. in
Vitro 16: 141-150, 2002.
Okamoto, H., Prestwich, S. A., Asai, S., Unno, T., Bolton, T. B. and Komori, S.: Muscarinic agonist potencies at three different effector systems linked to the M2 and M3 receptor in longitudinal smooth muscle of guinea-pig small intestine.
Br. J. Pharmacol. 135: 1765-1775, 2002.
Saito, H., Thapaliya, S., Matsuyama, H., Nishimura, M., Unno, T., Komori,
S. and Takewaki, T.: Reversible impairment of endothelium-dependent relaxation
in golden hamster carotid arteries during hibernation. J. Physiol. 540:
285-294, 2002.
海野年弘, 稲葉裕次, 小森成一: 環境における毒物−有機スズ化合物による神経毒性−. Jpn. J. Zoo Wildl. Med. 7: 53-59, 2002.
Izumi, N., Matsuyama, H., Yamamoto, Y., Atoji, Y., Suzuki, Y., Unno, T. and Takewaki, T.: Morphological and morphometrical characteristics of the esophageal intrinsic nervous system in the golden hamster. Eur. J. Morphol. 40: 137-144, 2002.
2001年
Kitoh, K., Oka, A., Kitagawa, H., Unno, T., Komori, S. and Sasaki, Y.:
Relaxing and contracting activities of heartworm extract on isolated canine
abdominal aorta. J. Parastol. 87: 522-526 2001.
2000年
Kawarada, S., Unno, T., Ohash, H. and Komori, S.: Neurotensin-induced Cl- current in guinea-pig dorsal root ganglion cells. Eur. J. Pharmacol. 404:
69-78, 2000.
Iwata, M., Unno, T., Minamoto, N., Ohashi, H. and Komori, S.: Rabies virus infection prevents the modulation by a2-adrenoceptors, but not muscarinic receptors, of Ca2+ channels in NG108-15 cells. Eur. J. Pharmacol. 404: 79-88, 2000.
Unno, T., Inaba, T., Ohashi, H., Takewaki, T. and Komori, S.: Role of Ca2+ mobilization in muscarinic receptor-mediated membrane depolarization in
guinea pig ileal smooth muscle cells. Jpn. J. Pharmacol. 84: 431-437, 2000.
Oda, A., Ohashi, H., Komori, S., Iida, H., Dohi, S.: Characteristics of ropivacaine block of Na+ channels in rat dorsal root ganglion neurons. Anesth Analg. 91:1213-1220,
2000
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