最近の研究業績 of 岐阜大学 人獣共通感染症学研究室のホームページ

最近の研究業績

2017年
Nakagawa, K., Kobayashi, Y., Ito, N., Suzuki, Y., Okada, K., Makino, M., Goto, H., Takahashi, T., and Sugiyama, M. Molecular Function Analysis of Rabies Virus RNA Polymerase L Protein by Using an L Gene-Deficient Virus. J. Virol. 2017 (in press).
Yamaoka, S., Okada, K., Ito, N., Okadera, K., Mitake, H., Nakagawa, K., and Sugiyama, M. Defect of rabies virus phosphoprotein in its interferon-antagonist activity negatively affects viral replication in muscle cells. J. Vet. Med. Sci. 2017 (in press).LinkIcon詳細はこちらから
2016年
Ito, N., Moseley, G. W., and Sugiyama, M. The importance of immune evasion in the pathogenesis of rabies virus. J. Vet. Med. Sci. 78:1089-1098, 2016.【総説】LinkIcon詳細はこちらから
Okada, K., Ito, N., Yamaoka, S., Masatani, T., Ebihara, H., Goto, H., Nakagawa, K., Mitake, H., Okadera, K., and Sugiyama, M. Roles of the rabies virus phosphoprotein isoforms in pathogenesis. J. Virol. 90: 8226-8237, 2016.LinkIcon詳細はこちらから
Mitake, H., Fuji, Y., Nagai, M., Ito, N., Okadera, K., Okada, K., Nakagawa, K., Kishimoto, M., Mizutani, T., Okazaki, K., Sakoda, Y., Takada, A., and Sugiyama, M. Isolation of a sp. nov. Ljungan virus from wild birds in Japan. J. Gen. Virol. 97:1818-1822, 2016.LinkIcon詳細はこちらから
Okadera, K., Abe, M., Ito, N., Mitake, H., Okada, K., Nakagawa, K., Une, Y., Tsunemitsu, H., and Sugiyama, M. Isolation and Characterization of a Novel Type of Rotavirus Species A in Sugar Gliders (Petaurus Breviceps). J. Gen. Virol. 97: 1158-1167, 2016.LinkIcon詳細はこちらから
Fujii, Y., Mitake, H., Yamada, D., Nagai, M., Okadera, K., Ito, N., Okada, K., Nagagawa, K., Mizutani, T., and Sugiyama, M. Genome sequences of rotavirus A strains Ty-1 and Ty-3 isolated from turkeys in Ireland in 1979. Genome announcements 4: pii: e01565-15, 2016.LinkIcon詳細はこちらから
2015年
Mitake, H., Ito, N., Okadera, K., Okada, K., Nakagawa, K., Tanaka, T., Katsuragi, K., Kasahara, K., Nihongi, T., Sakurai, S., Tsunemitsu, H., and Sugiyama, M. Persistence of Rotavirus A Genome in Mesenteric Lymph Nodes of Cattle Raised in Farms. J. Gen. Virol. 96: 2708-2713, 2015.LinkIcon詳細はこちらから
Mitake, H., Ito, N., Okadera, K., Okada, K., Nakagawa, K., Tanaka, T., Katsuragi, K., Nihongi, T., Tsunemitsu, H. and Sugiyama, M. Detection of Avian-like Rotavirus A VP4 from a Calf in Japan. J. Vet. Med. Sci., 77, 221-224, 2015.LinkIcon詳細はこちらから
2013年
Yamaoka, S., Ito, N., Ohka, S., Kaneda, S., Nakamura, H., Agari, T., Masatani, T., Nakagawa, K., Okada, K., Okadera, K., Mitake, H., Fujii, T., and Sugiyama, M. Involvement of rabies virus phosphoprotein gene in neuroinvasiveness. J. Virol. 87, 12327-12338, 2013.LinkIcon詳細はこちらから
Okadera, K., Abe, M., Ito, N., Morikawa, S., Yamasaki, A., Masatani, T., Nakagawa, K., Yamaoka, S., Sugiyama, M. Evidence of natural transmission of group A rotavirus between domestic pigs and wild boars (Sus scrofa) in Japan. Infect. Genet. Evol. 20, 54-60, 2013.LinkIcon詳細はこちらから
Masatani, T., Ito, N., Ito, Y., Nakagawa, K., Abe, M., Yamaoka, S., Okadera, K., Sugiyama, M. Importance of rabies virus nucleoprotein in viral evasion of interferon response in the brain. Microbiol. Immunol. 57, 511-517, 2013.LinkIcon詳細はこちらから
2012年
Nakagawa, K., Ito, N., Masatani, T., Abe, M., Yamaoka, S., Ito, Y., Okadera, K., Sugiyama, M. Generation of a live rabies vaccine strain attenuated by multiple mutations and evaluation of its safety and efficacy. Vaccine 30, 3610-3617 2012.LinkIcon詳細はこちらから
2011年
Ito, N., Mita, T., Shimizu, K., Ito, Y., Masatani, T., Nakagawa, K., Yamaoka, S., Abe, M., Minamoto, N., Sugiyama, M. Amino acid substitution at position 95 in rabies virus matrix protein affects viral pathogenicity. J. Vet. Med. Sci. 73, 1363-1366, 2011.LinkIcon詳細はこちらから
Abe, M., Ito, N., Sakai, K., Kaku, Y., Oba, M., Nishimura, M., Kurane, I., Saijo, M., Morikawa, S., Sugiyama, M., Mizutani, T. A novel sapelovirus-like virus isolation from wild boar. Virus Genes, 43, 243-248, 2011.LinkIcon詳細はこちらから
Abe, M., Ito, N., Masatani, T., Nakagawa, K., Yamaoka, S., Kanamaru, Y., Suzuki, H., Shibano, K., Arashi, Y., Sugiyama, M. Whole genome characterization of new bovine rotavirus G21P[29] and G24P[33] strains provides evidence for interspecies transmission. J. Gen. Virol., 92, 952-960, 2011.LinkIcon詳細はこちらから
Masatani, T., Ito, N., Shimizu, K., Ito, Y., Nakagawa, K., Abe, M., Yamaoka, S., Sugiyama, M. Amino acids at positions 273 and 394 in rabies virus nucleoprotein are important for both evasion of host RIG-I-mediated antiviral response and pathogenicity. Virus. Res., 155, 168-174, 2011.LinkIcon詳細はこちらから
2010年
Abe, M., Yamasaki, A., Ito, N., Mizoguchi, T., Asano, M., Okano, T., Sugiyama., M. Molecular characterization of rotaviruses in a Japanese raccoon dog (Nyctereutes procyonoides) and a masked palm civet (Paguma larvata) in Japan, Vet. Microbiol., 146, 253-259, 2010.LinkIcon詳細はこちらから
Ito, N., Moseley, G.W., Blondel, D., Shimizu, K., Rowe, C.L., Ito, Y., Masatani, T., Nakagawa, K., Jans, D.A., Sugiyama, M. The role of interferon-antagonist activity of rabies virus phosphoprotein in viral pathogenicity. J. Virol., 84, 6699-6710, 2010.LinkIcon詳細はこちらから
Masatani, T., Ito, N., Shimizu, K., Ito, Y., Nakagawa, K., Sawaki, Y., Koyama, H., Sugiyama, M. Rabies virus nucleoprotein functions to evade activation of RIG-I-mediated antiviral response. J. Virol. 84, 4002-4012, 2010.LinkIcon詳細はこちらから
Ito, Y., Ito, N., Saito, S., Masatani, T., Nakagawa, K., Atoji, Y., Sugiyama., M. Amino acid substitutions at positions 242, 255 and 268 in rabies virus glycoprotein affect spread of viral infection. Microbiol. Immunol. 54, 89-97, 2010.LinkIcon詳細はこちらから
2009年
Abe, M., Ito, N., Morikawa, S., Takasu, M., Murase, T., Kawashima, T., Kawai, Y., Kohara, J., Sugiyama, M. Molecular epidemiology of rotaviruses among healthy calves in Japan: Isolation of a novel bovine rotavirus bearing new P and G genotypes. Virus Res. 144, 250-257,2009.LinkIcon詳細はこちらから
2008年
Mita, T., Shimizu, K., Ito, N., Yamada, K., Ito, Y., Sugiyama, M., Minamoto, N. Amino acid at position 95 of the matrix protein is a cytopathic determinant of rabies virus. Virus Res. 137: 33-39, 2008.
Susetya, H., Sugiyama, M., Inagaki, A., Ito, N., Mudiarto, G., Minamoto, N. Molecular epidemiology of rabies in Indonesia. Virus Res. 135: 144-149, 2008.
2007年
Borghan, M. A., Mori, Y., El-Mahmoudy, A., Ito, N., Sugiyama, M., Takewaki, T., Minamoto, N. Induction of nitric oxide synthase by rotavirus enterotoxin NSP4: implication for rotavirus pathogenicity. J. Gen. Virol., 88: 2064-2072, 2007.
Shimizu, K., Ito, N., Mita, T., Yamada, K., Hosokawa-Muto, J., Sugiyama, M., Minamoto, N. Involvement of nucleoprotein, phosphoprotein, and matrix protein genes of rabies virus in virulence for adult mice. Virus Res. 123: 154-160, 2007.
Sugiyama, M., Ito, N. Control of rabies: Epidemiology of rabies in Asia and development of new-generation vaccines for rabies. Comp. Immunol. Microbiol. Infect. Dis. 30: 273-286, 2007.【総説】
伊藤直人、杉山誠:狂犬病ウイルスの病原性に関する研究の進展. ウイルス57巻2号: 191-198, 2007.【総説】LinkIconダウンロード・ページ
2006年
Shimizu, K., Ito, N., Sugiyama, M., Minamoto, N. Sensitivity of rabies virus to type I interferon is determined by the phosphoportein gene. Microbiol. Immunol. 50:975-978, 2006.
Hosokawa-Muto, J., Ito, N., Yamada, K., Shimizu, K., Sugiyama, M., Minamoto, N. Characterization of recombinant rabies virus carrying double glycoprotein genes. Microbiol. Immunol. 50: 187-196, 2006.
Yamada, K., Ito, N., Takayama-Ito, M., Sugiyama, M., Minamoto, M. Multigenic relation to the attenuation of rabies virus. Microbiol. Immunol. 50: 25-32, 2006.
Takayama-Ito,M., Ito, N., Yamada, K., Sugiyama, M., Nobuyuki Minamoto. Multiple amino acids in the glycoprotein of rabies virus are responsible for pathogenicity in adult mice. Virus Res. 115: 169-175, 2006.
2005年
Ito, N., Sugiyama, M., Yamada, K., Shimizu, K., Takayama-Ito, M., Hosokawa, J., Minamoto, N. Characterization of M Gene-Deficient Rabies Virus with Advantages of Effective Immunization and Safety as a Vaccine Strain. Microbiol. Immunol. 49: 971-979, 2005.
2004年
Takayama-Ito, M., Ito, N., Yamada, K., Minamoto, N., Sugiyama, M. Region at amino acids 164 to 303 of the rabies virus glycoprotein plays an important role in pathogenicity for adult mice. J. Neurovirol. 10: 131-135, 2004.
Sugiyama, M., Goto, K., Uemukai H., Mori, Y., Ito, N., Minamoto, N. Attachment and infection to MA104 cells of avian rotaviruses require the presence of sialic acid on the cell surface. J. Vet. Med. Sci. 66: 461-463, 2004.
2003年
Mori, Y., Borgan, M. A., Takayama, M., Ito, N., Sugiyama, M., Minamoto, N. Roles of outer capsid proteins as determinants of pathogenicity and host range restriction of avian rotaviruses in a suckling mouse model. Virology 316: 126-134, 2003.
Borgan, M. A., Mori, Y., Ito, N., Sugiyama, M., Minamoto, N. Antigenic analysis of nonstructural protein (NSP) 4 of group A avian rotavirus strain PO-13. Microbiol. Immunol. 47: 661-668, 2003.
Susetya, H., Sugiyama, M., Inagaki, A., Ito, N., Oraveerakul, K., Traiwanatham, N., Minamoto, N. Genetic characterization of rabies field isolates from Thailand. Microbiol. Immunol. 47: 653-659, 2003.
Ito, N., Takayama-Ito, M., Yamada, K., Hosokawa, J., Sugiyama, M., Minamoto, N. Improved recovery of rabies virus from cloned cDNA using a vaccinia virus-free reverse genetics system. Microbiol. Immunol. 47: 613-617, 2003.
Sugiyama, M., Ito, N., Minamoto, N. Isothermal amplification of rabies virus gene. J. Vet. Med. Sci. 65, 1063-1068, 2003.
2002年
Mori, Y., Borgan, M. A., Ito, N., Sugiyama, M., Minamoto, N. Sequential analysis of nonstructural protein NSP4s derived from Group A avian rotaviruses. Virus Res. 89: 145-151, 2002.
Mori, Y., Borgan, M. A., Ito, N., Sugiyama, M., Minamoto, N. Diarrhea-inducing activity of avian rotavirus NSP4 glycoproteins, which differ greatly from mammalian rotavirus NSP4 glycoproteins in deduced amino acid sequence, in suckling mice. J. Virol. 76: 5829-5834, 2002.
Sugiyama, M., Ito, N., Minamoto, N., Tanaka S. Identification of immunodominant neutralizing epitopes on hemagglutinin protein of rinderpest virus. J. Virol. 76:1691-1696, 2002.
2001年
Ito, N., Takayama, M., Yamada, K., Sugiyama, M., Minamoto, N. Rescue of rabies virus from cloned cDNA and identification of the pathogenicity-related gene: Glycoprotein gene is asociated with virulence for adult mice. J. Virol. 75: 9121-9128, 2001.
Ito, N., Kakemizu, M., Ito, K.A., Yamamoto, A., Yoshida, Y., Sugiyama, M., Minamoto, N. A comparison of complete genome sequences of the attenuated RC-HL strain of rabies virus used for production of animal vaccine in Japan, and the parental Nishigahara strain. Microbiol. Immunol. 45: 51-58, 2001.
Mori, Y., Sugiyama, M., Takayama, M., Atoji, Y., Masegi, T., Minamoto, N. Avian-to-mammal transmission of an avian rotavirus: analysis of its pathogenicity in a heterologous mouse model., Virology 288: 63-70, 2001.
2000年
Goto, H., Minamoto, N., Ito, H., Ito, N., Sugiyama, M., Kinjo, T., Kawai A. Mapping of epitopes and structual analysis of antigenic sites in the nucleoprotein of rabies virus. J. Gen. Virol. 81: 119-127, 2000.