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I have conducted research on the metabolism abnormality of peroxisomes, one of the intracellular organelles, for many years now. As the only peroxisome disorder diagnosis center in Japan, we have been asked to examine a number of patients, during the course of which we discovered new genetic disorders and temperature-sensitive phenomenon, as well as advocated "Gifu University Classification" in Peroxisome Biogenesis Disorders.
There is still a lot that we do not know about actual in vivo function of peroxisomes. As such, I would like to include so-called "metabdomics", the focusing on GCMS to study the metabolic products of living organisms, in genomics and proteomics research to create an analysis system that would establish a comprehensive research division on peroxisome metabolic disorders to cover everything from single-gene "metabolic syndrome". In the future, I hope disease research will have developed so that we can comprehensively analyze and understand all metabolic disorders.
Peroxisomes exist in a variety of organisms, from yeasts to plants and animals. They share common physiologic functions, and in order to understand them better I would like to plan a large joint research project with many other researchers form both within and outside of Gifu University.
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