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最近の論文

平成23年度から現在までに発表した論文の一覧です。
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Satoshi Endo, Shuang Xia, Miho Suyama, Yoshifumi Morikawa, Hiroaki Oguri, Dawei Hu, Yoshinori Ao, Satoyuki Takahara, Yoshikazu Horino, Yoshihiro Hayakawa, Yurie Watanabe, Hiroaki Gouda, Akira Hara, Kazuo Kuwata, Naoki Toyooka, Toshiyuki Matsunaga, and Akira Ikari. Synthesis of Potent and Selective Inhibitors of Aldo-Keto Reductase 1B10 and Their Efficacy against Proliferation, Metastasis, and Cisplatin Resistance of Lung Cancer Cells. Journal of medicinal chemistry. 2017 Oct 13. doi: 10.1021/acs.jmedchem.7b00830.

Amin Tahoun, Hisayoshi Masutani, Hanem El-Sharkawy, Trudi Gillespie, Ryo P. Honda, Kazuo Kuwata, Mizuho Inagaki, Tomio Yabe, Izumi Nomura,and Tohru Suzukicorresponding. Capsular polysaccharide inhibits adhesion of Bifidobacterium longum 105-A to enterocyte-like Caco-2 cells and phagocytosis by macrophages.Gut pathogens. 2017 May 1;9:27. doi: 10.1186/s13099-017-0177-x. eCollection 2017.

Ryo P. Honda & Kazuo Kuwata, The native state of prion protein (PrP) directly inhibits formation of PrP-amyloid fibrils in vitro, Scientific Reports 7, Article number: 562 (2017), doi:10.1038/s41598-017-00710-x

Satoshi Endo, Sayaka Takada, Ryo P. Honda, Kathrin Muller, Jochen H. Weishaupt, Peter M. Andersen, Albert C. Ludolph, Yuji O. Kamatari, Toshiyuki Matsunaga, Kazuo Kuwata, Ossama El-Kabbani, and Akira Ikari: Instability of C154Y variant of aldo-keto reductase 1C3, Chemico-Biological Interactions, 2016 Dec 23. pii: S0009-2797(16)30758-X. doi: 10.1016/j.cbi.2016.12.018. [Epub ahead of print] (2017)

Kabir Aurangazeb, Satoshi Endo, Naoki Toyooka, Mayuko Fukuoka, Kazuo Kuwata, and Yuji O. Kamatari: Evaluation of compound selectivity of aldo-keto reductases using differential scanning fluorimetry.Journal of Biochemistry, 161(2):215-222 (2017)

Kabir Aurangazeb, Ryo P. Honda, Yuji O. Kamatari, Satoshi Endo, Mayuko Fukuoka, and Kazuo Kuwata: Effects of ligand binding on the stability of aldo-keto reductases (AKR), Protein Science, 25(12):2132-41 (2016)

Ferdausi Ali, Keiichi Yamaguchi, Mayuko Fukuoka, Abdelazim Elsayed Elhelely, and Kazuo Kuwata: Logical design of an anti-cancer agent targeting the Plant Homeodomain (PHD) in Pygopus2, Cancer Science, 107(9):1321-8 (2016)

Nongluk Sriwilaijaroen, Sadagopan Magesh, Akihiro Imamura, Hiromune Ando, Hideharu Ishida, Miho Sakai, Erika Ishitsubo, Takanori Hori, Setsuko Moriya, Takeshi Ishikawa, Kazuo Kuwata, Takato Odagiri, Masato Tashiro, Hiroaki Hiramatsu, Kenji Tsukamoto, Taeko Miyagi, Hiroaki Tokiwa, Makoto Kiso, and Yasuo Suzuki: A Novel Potent and Highly Specific Inhibitor against Influenza Viral N1 N9 Neuraminidases: Insight into Neuraminidase Inhibitor Interactions, Journal of medicinal chemistry, 59(10):4563-77 (2016)

Ma Biao, Yamaguchi Keiichi, Fukuoka Mayuko, and Kuwata Kazuo: Logical design of anti-prion agents using NAGARA. Biochem Biophys Res Commun, 469(4):930-5 (2016)

Tomotaka Oroguchi, Yuki Sekiguchi1, Amane Kobayash, Yu Masaki, Asahi Fukuda, Saki Hashimoto, Masayoshi Nakasako, Yuichi Ichikawa, Hitoshi Kurumizaka, Mitsuhiro Shimizu, Yayoi Inui, Sachihiro Matsunaga, Takayuki Kato, Keiichi Namba, Keiichi Yamaguchi, Kazuo Kuwata, Hiroshi Kameda, Naoya Fukui, Yasushi Kawata, Takashi Kameshima, Yuki Takayama, Koji Yonekura and Masaki Yamamoto: Cryogenic coherent X-ray diffraction imaging biological non-crystalline particles using the KOTOBUKI-1 diffraction apparatus at SACLA. Journal of Physics B, 48(18) (2015)

Ryo P. Honda, Ming Xu, Kei-ichi Yamaguchi, Heinrich Roder and Kazuo Kuwata: A Native-like Intermediate Serves as a Branching Point between the Folding and Aggregation Pathways of the Mouse Prion Protein. Structure, 1;23(9):1735-1742 (2015)

Junji Hosokawa-Muto, Kei-ichi Yamaguchi, Yuji O. Kamatari and Kazuo Kuwata: Synthesis of double-fluorescent labeled prion protein for FRET analysis. Bioscience, biotechnology, and biochemistry, 79(11):1802-9 (2015)

Ryo P. Honda, Kei-ichi Yamaguchi and Kazuo Kuwata: Acid-induced Molten Globule State of a Prion Protein: Crucial Role of Strand 1-Helix 1-Strand 2 Segment. The Journal of biological chemistry, 289(44):30355-63 (2014)

Takehiro Nakagaki, Katsuya Satoh, Daisuke Ishibashi, Takayuki Fuse, Kazunori Sano, Yuji O. Kamatari, Kazuo Kuwata, Kazuto Shigematsu, Yoshifumi Iwamaru, Takato Takenouchi, Hiroshi Kitani, Noriyuki Nishida, and Ryouichiro Atarashi: FK506 reduces abnormal prion protein through the activation of autolysosomal degradation and prolongs survival in prion-infected mice. Autophagy, 9(9) 1386-94 (2013)

Kuwata Kazuo: Logical design of medical chaperone for prion diseases. Current topics in medicinal chemistry, 13(19) 2432-40 (2013)

Keiichi Yamaguchi, Yuji O. Kamatari, Mayuko Fukuoka, Reiji Miyaji, and Kazuo Kuwata: Nearly reversible conformational change of amyloid fibrils as revealed by pH-jump experiments. Biochemistry, 52(39) 6797-806 (2013)

Tsutomu Kimura, Takeo Sako, Siqin, Junji Hosokawa-Muto, Yi Long Cui, Yasuhiro Wada, Yosky Kataoka, Hisashi Doi, Suehiro Sakaguchi, Masaaki Suzuki, Yasuyoshi Watanabe,and Kazuo Kuwata: Synthesis of an 11C-Labeled Antiprion GN8 Derivative and Evaluation of Its Brain Uptake by Positron Emission Tomography. ChemMedChem, 8(7) 1035-1039 (2013)

Satoshi Endo, Dawei HU, Miho Suyama, Toshiyuki Matsunaga, Kenji Sugimoto, Yuji Matsuya, Ossama El-Kabbani, Kazuo Kuwata, Akira Hara, Yukio Kitade, and Naoki Toyooka: Synthesis and structure-activity relationship of 2-phenyliminochromene derivatives as inhibitors for AKR1B10. Bioorganic & Medicinal Chemistry, 21(21) 6378-84 (2013)

Le Chang, Takeshi Ishikawa, Kazuo Kuwata, and Shoji Takada: Protein-specific force derived from the fragment molecular orbital method can improve protein-ligand binding interactive. Journal of Computational Chemistry, 34(14) 1251-1257 (2013)

Takeshi Ishikawa, Raghunadha Reddy Burri, Yuji O. Kamatari, Shun Sakuraba, Nobuyuki Matubayasi, Akio Kitao and Kazuo Kuwata: A theoretical study of the two binding modes between lysozyme and tri-NAG with an explicit solvent model based on the fragment molecular orbital method. Physical chemistry chemical physics, 15 3646-3654 (2013)

Kazuhiro Takemura, Raghunadha Reddy Burri, Takeshi Ishikawa, Takakazu Ishikura, Shun Sakuraba, Nobuyuki Matubayasi, Kazuo Kuwata, and Akio Kitao: Free-energy analysis of lysozyme-triNAG binding modes with all-atom molecular dynamics simulation combined with the solution theory in the energy representation. Chemical physics letters, 559 94-98 (2013)

Mashima Tsukasa, Nishikawa Fumiko, Kamatari Yuji, Fujiwara Hiromichi, Saimura Masayuki, Nagata Takashi, Kodaki Tsutomu, Nishiwaka Satoshi, Kuwata Kazuo, and Katahira Masato: Anti-prion activity of an RNA aptamer and its structural basis. Nucleic Acids Research, 41(2) 1355-1362 (2013)

Takuya Okamoto, Takeshi Ishikawa, Yoshiyuki Koyano, Norifumi Yamamoto, Kazuo Kuwata, Masataka Nagaoka: A minimal implementation of the AMBER-PAICS interface for Ab initio FMO-QM/MM-MD simulation. Bulletin of the Chemical Society of Japan, 86(2) 210-222 (2013)

Yuji Kamatari, Yosuke Hayano, Kei-ichi Yamaguchi, Junji Hosokawa-Muto, Kazuo Kuwata: Characterizing antiprion compounds based on their binding properties to prion proteins: Implications as medical chaperones. Protein Science, 22(1) 22-34 (2012)

Ishikawa Takeshi, Kuwata Kazuo: RI-MP2 Gradient Calculation of Large Molecules Using the Fragment Molecular Orbital Method.  Journal of Physical Chemistry Letters, 3(3) 375-379 (2012)

Kazunori Yamada, Hiroko Koyama, Kyoji Hagiwara, Atsushi Ueda, Yutaka Sasaki, Shin-nosuke Kanesashi, Ryuki Ueno, Hironori K. Nakamura, Kazuo Kuwata, Kazufumi Shimizu, Masaaki Suzuki, and Yoko Aida: Identification of a novel compound with antiviral activity against influenza A virus depending on PA subunit of viral RNA polymerase. Microbes and Infection, 14(9) 740-747 (2012)

Kazuo Kuwata: Non-commutative Geometrical Drug Discovery - The Principle of Geometrical Regulation. YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 132(8) 873-879 (2012)

Mayuko Fukuoka, Moeko Minakuchi, Atsushi Kawaguchi, Kyosuke Nagata, Yuji O. Kamatari, and Kazuo Kuwata: Structure based discovery of anti-influenza virus A compounds among medicines. Biochimica et Biophysica Acta (BBA) - General Subjects, 1820(2) 90-95 (2011)

Tomoaki Takemura, Tomohiko Urushisaki, Mayuko Fukuoka, Junji Hosokawa-Muto, Taketoshi Hata, Yumiko Okuda, Sachie Hori, Shigemi Tazawa, Yoko Araki, and Kazuo Kuwata: 3,4-Dicaffeoylquinic Acid, a Major Constituent of Brazilian Propolis, Increases TRAIL Expression and Extends the Lifetimes of Mice Infected with the Influenza A Virus. Evidence-Based Complementary and Alternative Medicine, Vol.2012 Article ID 946867, 7 pages (2012)

Keiichi Yamaguchi, Tomoharu Matsumoto, and Kazuo Kuwata: Proper calibration of ultrasonic power enabled the quantitative analysis of the ultrasonication-induced amyloid formation process. Protein Science, 21(1) 38-49 (2012)

Junji Hosokawa-Muto, Tsutomu Kimura, and Kazuo Kuwata: Respiratory and cardiovascular toxicity studies of a novel anti-prion compound, GN8, in rats and dogs. Drug and Chemical Toxicology, 35(3) 264-271 (2012)

Takeshi Ishikawa, Kazuo Kuwata: RI-MP2 Gradient Calculation of Large Molecules Using the Fragment Molecular Orbital Method, The Journal of Physical Chemistry Letters, 3(3) 375-379 (2012)

Tsutomu Kimura, Junji Hosokawa-Muto, Kenji Asami, Toshiaki Murai, and Kazuo Kuwata: Synthesis of 9-substituted 2,3,4,9- tetrahydro-1H-carbazole derivatives and evaluation of their anti-prion activity in TSE-infected cells. European Journal of Medicinal Chemistry, 46 5675-5679 (2011)

Narinder Sanghera, Bruno E.F.S. Correia, Joana R.S. Correia, Christian Ludwig, Sonya Agarwal, Hironori K. Nakamura, Kazuo Kuwata, Eric Samain, Andrew C. Gill, Boyan B. Bonev, and Teresa J.T. Pinheiro: Deciphering the Molecular Details for the Binding of the Prion Protein to Main Ganglioside GM1 of Neuronal Membranes. Chemistry & biology, 18 1422-31 (2011)

Tomohiko Urushisaki, Tomoaki Takemura, Shigemi Tazawa, Mayuko Fukuoka, Junji Hosokawa-Muto, Yoko Araki, and Kazuo Kuwata: Caffeoylquinic Acids Are Major Constituents with Potent Anti-Influenza Effects in Brazilian Green Propolis Water Extract. Evidence-Based Complementary and Alternative Medicine, Vol.2011,Article ID254914, 7Pages (2011)

Tsutomu Kimura, Junji Hosokawa-Muto, Yuji O.Kamatari, and Kazuo Kuwata: Synthesis of GN8 derivatives and evaluation of their antiprion activity in TSE-infected cells. Bioorganic & Medicinal Chemistry Letters, 21 1502-1507 (2011)

岐阜大学大学院連合創薬医療情報研究科医療情報学専攻

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