Gifu University Faculty of Applied Biology
Gifu University The United Graduate School of Veterinary Science
Laboratory of Veterinary Physiology
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Research publications



@2012
  • Shiina T., Shima T., Suzuki Y., Worl, J., Shimizu Y.
    Neural regulation of esophageal striated muscle in the house musk shrew (Suncus murinus).
    Auton. Neurosci. in press


  • Nakamori C., Shiina T., Shimizu Y.
    Postnatal changes in vagal control of esophageal muscle contractions in rats.
    Life Sci. in press




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@2011
  • Alkayed F., Shiina T, Takewaki T., Shimizu Y.
    Postnatal development of excitatory innervations in longitudinal smooth muscle of the chicken anterior mesenteric artery.
    Life Sci. 88: 400-405, 2011


  • Iwami M., Mahmoud F.A., Shiina,T., Hirayama H., Shima T., Sugita J., Shimizu Y.
    Extract of grains of paradise and its active principle 6-paradol trigger thermogenesis of brown adipose tissue in rats.
    Auton. Neurosci.
    161: 63-67, 2011.


  • Abe C., Iwata C., Shiina T., Shimizu Y., Morita H.
    Effect of daily linear acceleration training on the hypergravity-induced vomiting response in house musk shrew (Suncus murinus).
    Neurosci Lett. 502:138-142, 2011


  • Iwami M., Shiina T., Hirayama H., Shima T., Takewaki T., Shimizu Y.
    Inhibitory effects of zingerone, a pungent component of Zingiber officinale Roscoe, on colonic motility in rats.
    J. Nat. Med. 65: 89-94, 2011


  • Iwami M., Shiina T., Hirayama H., Shimizu Y.
    Intraluminal administration of zingerol, a non-pungent analogue of zingerone, inhibits colonic motility in rats.
    Biomed. Res. 32: 181-185, 2011



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@2010
  • Hirayama H., Shiina T., Shima T., Kuramoto H., Takewaki T., Furness J.B., Shimizu Y.
    Contrasting effects of ghrelin and des-acyl ghrelin on the lumbo-sacral defecation center and regulation of colorectal motility in rats.
    Neurogastroenterol. Motil. 22: 1124-1131, 2010


  • Shiina T., Shima T., Masuda K., Hirayama H., Iwami M., Takewaki T., Kuramoto H., Shimizu Y.
    Contractile properties of esophageal striated muscle: comparison with cardiac and skeletal muscles in rats.
    J. Biomed. Biotech. vol. 2010, Article ID 459789, 7 pages, 2010


  • Mahmoud M.E., Nikami H., Shiina T., Takewaki T., Shimizu Y.
    Capsaicin inhibits IFN-gamma-induced MHC class II expression by suppressing transcription of class II transactivator gene in murine peritoneal macrophages.
    Int. Immunopharmacol. 10:86-90, 2010


  • Shiina T., Shima T., Hirayama H., Kuramoto H., Takewaki T., Shimizu Y.
    Contractile responses induced by physalaemin, an analogue of substance P, in the rat esophagus.
    Eur. J. Pharmacol. 628: 202-206, 2010


  • Shiina T., Shima T., Worl J., Neuhuber W.L., Shimizu Y.
    The neural regulation of the mammalian esophageal motility and its implication for esophageal diseases. (Review)
    Pathophysiology 17:129-133, 2010


  • Ferens D.M., Yin L., Bron R., Hunne B., Ohashi-Doi K., Kitchener P.D., Sanger G.J., Witherington J., Shimizu Y., Furness,J.B.
    Functional and in situ hybridisation evidence that preganglionic sympathetic vasoconstrictor neurons express ghrelin receptors.
    Neuroscience 166:671-679, 2010


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@2009
  • Alkayed, F., Boudaka, A., Shiina T, Takewaki, T., Shimizu, Y.
    P2X purinoceptors mediate an endothelium-dependent hyperpolarization in longitudinal smooth muscle of anterior mesenteric artery in young chickens.
    Br. J. Phramacol. 158:888-895, 2009


  • Boudaka A, Worl J, Shiina T, Shimizu Y, Takewaki T., Neuhuber WL
    Galanin modulates vagally induced contractions in the mouse esophagus.
    Neurogastroenterol. Motil. 21:180-188, 2009


  • Shafton, A.D., Sanger, G.J., Witherington, J., Brown, J.D., Muir, A., Butler, S., Abberley, L., Shimizu, Y., Furness, J.B.
    Oral administration of a centrally-acting ghrelin receptor agonist to conscious rats triggers defecation.
    Neurogastroenterol. Motil. 21: 71-77, 2009


  • Miyazawa, S., Shiina, T., Takewaki, T., Shimizu, Y.
    Extension of time until cardiac arrest after injection of a lethal dose of pentobarbital in the hibernating Syrian hamster.
    J. Vet. Med. Sci. 71:383-385, 2009


  • Seddek, A.l.S., Mahmoud, M.E., Shiina, T., Hirayama, H., Iwami, M., Miyazawa, S., Nikami, H., Takewaki, T., Shimizu, Y.
    Activation of murine macrophages by the extract from Calotropis procera latex.
    J. Nat. Med. 63:297-303, 2009


  • Hempfling C, Seibold R, Shiina T, Heimler W, Neuhuber WL, Woerl J.
    Enteric co-innervation of esophageal striated muscle fibers: A phylogenetic study.
    Auton. Neurosci.. 151: 135-141, 2009

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    @2008

    • Miyazawa, S., Shimizu, Y., Shiina, T., Hirayama, H., Morita, H., Takewaki, T.
      Central A1-receptor activation associated with onset of torpor protects the heart against low temperature in the Syrian hamster.
      Am. J. Physiol. 295: R991-996, 2008


    • Nikami, H., Mahmoud, M.E., Shimizu, Y., Shiina, T., Hirayama, H., Iwami, M., Dosoky, R.M., Ahmed, M.M., Takewaki, T.
      Capsaicin pretreatment attenuates LPS-induced hypothermia through TRPV1-independent mechanisms in chicken.
      Life Sci. 82: 1191-1195, 2008


    • Shinozaki, K., Shimizu, Y., Shiina, T., Morita, H. and Takewaki, T.
      Relationship between taste-induced physiological reflexes and temperature of sweet taste.
      Physiol. Behav. 93:1000-1004, 2008


    • Shimizu, Y., Matsuyama, H., Shiina, T., Takewaki, T. and Furness, J.B.
      Tachykinins and their functions in the gastrointestinal tract (review).
      Cell. Mol. Life Sci. 65: 295-311, 2008


    • Furness, J.B., Nguyen, T.V., Nurgali, K., Shimizu, Y.
      Chapter 2: The enteric nervous system and its extrinsic connections.
      In Textbook of Gastroenterology 5th edition Yamada, T., Alpers, D., Owyang, C., Powell, D.W., Silverstein, F. eds. JB Lippincott, Philadelphia. 15-39, 2008.



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    @2007

    • Gurung, Y.B., Shimizu, Y., Shiina, T., Saito, S. and Takewaki, T.
      Impairment and restoration of spontaneous contractile activity of longitudinal smooth muscles in the TNBS-inflamed hamster distal colon.
      Biomed. Res. 28: 301-308, 2007


    • Mahmoud, M.E., Shimizu, Y., Shiina, T., Nikami, H., Dosoky, R.M., Ahmed, M.M., Takewaki, T.
      Involvement of a capsaicin-sensitive TRPV1-independent mechanism in lipopolysaccharide-induced fever in chickens.
      Comp. Biochem. Physiol. 148: 578-583, 2007


    • Borghan MA, Mori Y, El-Mahmoudy AB, Ito N, Sugiyama M, Takewaki T, Minamoto N.
      Induction of nitric oxide synthase by rotavirus enterotoxin NSP4: implication for rotavirus pathogenicity.
      J. Gen. Virol. 88: 2064-2072, 2007


    • Tonosaki, K., Hori, Y., Shimizu, Y., Tonosaki, K.
      Relationship between insulin release and taste.
      Biomed. Res. 28: 79-83, 2007


    • Shafton AD, Bogeski G, Kitchener P, Sanger GJ, Furness JB, Shimizu Y.
      Effects of NMDA receptor antagonists on visceromotor reflexes and on intestinal motility, in vivo.
      Neurogastroenterol. Motil. 19: 617-624, 2007


    • Boudaka A, Worl J, Shiina T, Neuhuber WL, Kobayashi H, Shimizu Y, Takewaki T.
      Involvement of TRPV1-dependent and -independent components in the regulation of vagally induced contractions in the mouse esophagus.
      Eur J Pharmacol. 556 :157-165, 2007


    • Boudaka A, Worl J, Shiina T, Saito S, Atoji Y, Kobayashi H, Shimizu Y, Takewaki T.
      Key role of mucosal primary afferents in mediating the inhibitory influence of capsaicin on vagally mediated contractions in the mouse esophagus.
      J Vet Med Sci. 69: 365-372, 2007


    • Shiina T, El-Mahmoudy A, Khalifa M, Draid M, Shimizu Y, Takewaki T.
      Purinergic control of the quail rectum: Modulation of adenosine 5
      '-triphosphate-mediated contraction with acetylcholine
      Res. Vet. Sci. 82:246-251, 2007


    • Shiina, T., Shimizu, Y., Boudaka, A., Worl, J., Neuhuber, W.L., Takewaki, T.
      Local neural regulation of the motility of the striated muscle portion in the mammalian esophagus.
      In Current Topics in Pharmacology Vol. 11 (1), 11-17, Richard, R. ed. Research Trends Ltd, Trivandrum, 2007.


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      @2006
      • Mubarak Hossain M, Suzuki T, Sato N, Sato I, Takewaki T, Suzuki K, Tachikawa E, Kobayashi H.
        Differential effects of pyrethroid insecticides on extracellular dopamine in the striatum of freely moving rats.
        Toxicol Appl Pharmacol. 217:25-34, 2006


      • El-Mahmoudy A, Khalifa M, Draid M, Shiina T, Shimizu Y, El-Sayed M, Takewaki T.
        NANC inhibitory neuromuscular transmission in the hamster distal colon.
        Pharmacol. Res. 54:452-560, 2006


      • Shimizu Y, Chang EC, Shafton AD, Ferens D, Sanger GJ, Witherington J, Furness JB.
        Evidence that stimulation of ghrelin receptors in the spinal cord initiates propulsive activity in the colon of the rat.
        J Physiol. 576: 329-338, 2006


      • Thompson-Vest N, Shimizu Y, Hunne B, Furness JB.
        The distribution of intermediate-conductance, calcium-activated, potassium (IK) channels in epithelial cells.
        J. Anat. 2: 219-229, 2006


      • Lang RJ, Nguyen DT, Matsuyama H, Takewaki T, Exintaris B.
        Characterization of spontaneous depolarizations in smooth muscle cells of the Guinea pig prostate.
        J. Urol. 175: 370-80, 2006



      • Shiina T, Shimizu Y, Boudaka A, Worl J, Takewaki T.
        Tachykinins are involved in local reflex modulation of vagally mediated striated muscle contractions in the rat esophagus via tachykinin NK1 receptors.
        Neuroscience 139: 495-503, 2006




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      @2005
      • Draid M, Shiina T, El-Mahmoudy A, Boudaka A, Shimizu Y, Takewaki T.
        Neurally released ATP mediates endothelium-dependent hyperpolarization in the circular smooth muscle cells of chicken anterior mesenteric artery.
        Br. J. Pharmacol. 146: 983-989, 2005.

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      • Saitoh M, Ishii T, Takewaki T, Nishimura M.
        Preference for Safflower Oil in Rats Exposed to a Cold Environment under Free-Feeding Conditions.
        J. Vet. Med. Sci. 67: 653-658, 2005.


      • Okishio Y, Takeuchi T, Fujita A, Suenaga K, Fujinami K, Munakata S, Takewaki T, Hata F.
        Ascending contraction and descending relaxation in the distal colon of mice lacking interstitial cells of Cajal.
        J. Smooth Muscle Res. 41:163-174, 2005.


      • Shiina T, Shimizu Y, Suzuki Y, Nikami H, Takewaki T.
        Measurement of the propelled liquid by isolated hamster ileum as a parameter to evaluate peristalsis.
        Eur. J. Pharmacol. 517:120-126, 2005.


      • Hossain MM, Suzuki T, Sato I, Takewaki T, Suzuki K, Kobayashi H.
        Neuromechanical effects of pyrethroids, allethrin, cyhalothrin and deltamethrin on the cholinergic processes in rat brain.
        Life Sci. 77:795-807, 2005.


      • Shinozaki K, Shimizu Y, Shiina T, Nishijima K, Atoji Y, Nikami H, Niijima A, Takewaki T.
        A neurophysiological evidence of capsaicin-sensitive nerve components innervating interscapular brown adipose tissue.
        Auton. Neurosci. 119:16-24, 2005.


      • Fararh KM, Shimizu Y, Shiina T, Nikami H, Ghanem MM, Takewaki T.
        Thymoquinone reduces hepatic glucose production in diabetic hamsters.
        Res. Vet. Sci. 79: 219-223, 2005.


      • Waseda K, Takeuchi T, Ohta M, Okishio Y, Fujita A, Hata F, Takewaki T.
        Participation of ATP in nonadrenergic, noncholinergic relaxation of longitudinal muscle of wistar rat jejunum.
        J. Pharmacol. Sci. 97:91-100, 2005.


      • Khalifa M, El-Mahmoudy A, Shiina T, Shimizu Y, Nikami H, El-Sayed M, Kobayashi H, Takewaki T.
        An electrophysiological study of excitatory purinergic neuromuscular transmission in longitudinal smooth muscle of chicken anterior mesenteric artery .
        Br. J. Pharmacol. 144: 830-839, 2005.


      • El-Mahmoudy A, Shimizu Y, Shiina T, Nikami H, Matsuyama H, Takewaki T.
        Macrophage-derived cytokine and nitric oxide profiles in typeI and typeII diabetes mellitus: effect of thymoquinone.
        Acta Diabetologica 42: 23-30, 2005.


      • Shiina T, Shimizu Y, Izumi N, Suzuki Y, Asano M, Atoji Y, Nikami H, Takewaki T.
        A comparative histological study on the distribution of striated and smooth muscles and glands in the esophagus of wild birds and mammals.
        J. Vet. Med. Sci. 67: 115-117, 2005.


      • El-Mahmoudy A, Shimizu Y, Shiina T, Matsuyama H, El-Sayed M, Takewaki T.
        Successful abrogation by thymoquinone against induction of diabetes mellitus with streptozotocin via nitric oxide inhibitory mechanism.
        Int. Immunopharmacol. 5: 195-207, 2005.
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      @2004
      • Fujita A, Okishio Y, Fujinami K, Nakagawa M, Takeuchi T, Takewaki T, Hata F.
        Role of the interstitial cells distributed in the myenteric plexus in neural reflexes in the mouse ileum.
        J. Pharmacol. Sci. 96: 483-92, 2004.


      • Fararh KM, Atoji Y, Shimizu Y, Shiina T, Nikami H, Takewaki T.
        Mechanism of hypoglycaemic and immunopotentiating effect of Nigella sativa L oil in streptozotocin-induced diabetic hamster.
        Res. Vet. Sci. 77:123-129, 2004.


      • Takeuchi T, Yamazaki Y, Negoro T, Fujinami K, Mukai K, Fujita A, Takewaki T, Hata F.
        Changes in mechanism of PACAP-induced relaxation in longitudinal muscle of the distal colon of Wistar rats with age.
        Regul. Pept. 118: 1-9, 2004.


      • Takeuchi T, Fujinami K,Fujita A, Okishio Y, Takewaki T, Hata F.
        Essential role of the interstitial cells of cajal in nitric oxide-mediated relaxation of longitudinal muscle of the mouse ileum.
        J. Pharmacol. Sci. 95:71-80, 2004.


      • Hossain MM, Suzuki T, Sato I, Takewaki T, Suzuki K, Kobayashi H.
        The modulatory effect of pyrethroids on acetylcholie release in the hippocampus of freely moving rats.
        NeuroToxicology 25:825-833, 2004.


      • Shiina T, Konno A, Oonuma T, Kitamura H, Imaoka K, Takeda N, Todokoro K, Morimatsu M.
        Targeted disruption of MAIL, a nuclear IkB protein, leads to severe atopic dermatitis-like disease.
        J. Biol. Chem. 279: 55493-55498, 2004.


      • Ito T, Morimatsu M, Oonuma T, Shiina T, Kitamura H, Syuto B.
        Transcriptional regulation of the MAIL gene in LPS stimulated RAW264 mouse macrophages.
        Gene 342:137-143, 2004.


      • Yamaji D, Kitamura H, Kimura K, Matsushita Y, Okada H, Shiina T, Morimatsu M, Saito M.
        Cloning of bovine MAIL and its mRNA expression in white blood cells of Holstein cows.
        Vet. Immunol. Immunopathol. 98:175-184. 2004.




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      @2003
      • El-Mahmoudy A, Matsuyama H, Khalifa M, Shimizu Y, Takewaki T.
        Tachykinins mediate non-adrenergic, non-cholinergic excitatory neurotransmission to the hamster ileum via NK1 and NK2 receptors.
        Life Sci. 73: 1939-1951, 2003.


      • Izumi N, Matsuyama H, Ko M, Shimizu Y, Takewaki T.
        Role of intrinsic nitrergic neurones on vagally-mediated striated muscle contractions in the hamster oesophagus.
        J. Physiol. 531: 287-294, 2003.


      • Shimizu Y, Yamazaki M, Nakanishi K, Sakurai M, Sanada A, Takewaki T, Tonosaki K.
        Enhanced responses of the chorda tympani nerve to sugars in the ventromedial hypothalamic obese rat.
        J. Neurophysiol. 90:128-133, 2003.


      • Matsuyama H, El-Mahmoudy A, Shimizu Y, Takewaki T.
        Nitrergic prejunctional inhibition of purinergic neuromuscular transmission in the hamster proximal colon.
        J. Neurophysiol. 89:2346-2353, 2003.


      • Thapaliya S, Matsuyama H, El-Mahmoudy A, Shimizu Y, Takewaki T.
        An endothelium-derived factor modulates purinergic neurotransmission to mesenteric arterial smooth muscle of hamster.
        Eur. J. Pharmacol. 461:129-137, 2003


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      @2002
      • Saito H, Thapaliya S, Matsuyama H, Nishimura M, Unno T, Komori S, Takewaki T.
        Reversible impairment of endothelium-dependent relaxation in golden hamster carotid arteries during hibernation.
        J. Physiol. 540:285-594, 2002.


      • Izumi N, Matsuyama H, Yamamoto Y, Atoji Y, Suzuki Y, Unno T, Takewaki T.
        Morphological and morphometrical characteristics of the esophageal intrinsic nervous system in the golden hamster.
        Eur. J. Morphol. 40:137-144. 2002.


      • Matsuyama H, Unno T, El-Mahmoudy AM, Komori S, Kobayashi H, Thapaliya S, Takewaki T.
        Peptidergic and nitrergic inhibitory neurotransmissions in the hamster jejunum: regulation of vasoactive intestinal peptide release by nitric oxide.
        Neuroscience 110:779-788, 2002.


      • Yamaji M, Ohta M, Yamazaki Y, Fujinami K, Fujita A, Takeuchi T, Hata F, Takewaki T.
        A possible role of neurotensin in NANC relaxation of longitudinal muscle of the jejunum and ileum of Wistar rats.
        Br. J. Pharmacol. 137:629-636, 2002.


      • Morita H, Sharada T, Takewaki T, Ito Y, Inoue R.
        Multiple regulation by external ATP of nifedipine-insensitive, high voltage-activated Ca(2+) current in guinea-pig mesenteric terminal arteriole.
        J. Physiol. 539:805-816, 2002.


      • El-Mahmoudy A, Matsuyama H, Borgan MA, Shimizu Y, El-Sayed MG, Minamoto N, Takewaki T.
        Thymoquinone suppresses expression of inducible nitric oxide synthase in rat macrophages.
        Int. Immunopharmacol. 2:1603-1611, 2002.


      • Fararh KM, Atoji Y, Shimizu Y, Takewaki T.
        Isulinotropic properties of Nigella sativa oil in Streptozotocin plus Nicotinamide diabetic hamster.
        Res. Vet. Sci. 73:279-282,.2002.


      • Shimizu Y, Shimazu T.
        Thyroid hormone augments GLUT4 expression and insulin-sensitive glucose transport system in differentiating rat brown adipocytes in culture.
        J. Vet. Med. Sci. 64:677-681, 2002.


      • Kitamura H, Kanehira K, Shiina T, Morimatsu M, Jung BD, Akashi S, Saito M.
        Bacterial lipopolysaccharide induces mRNA expression of an IkappaB MAIL through toll-like receptor 4.
        J. Vet. Med. Sci. 64:419-422, 2002.


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      @2001
      • Saito H, Thapaliya S, Matsuyama H, Nishimura M, Takewaki T.
        Enhancement of ATP release in hindlimb sympathetic perivascular nerve of the golden hamster during hibernation.
        J. Physiol. 531:495-507, 2001.


      • Kamata R, Saito S, Suzuki T, Takewaki T, Kobayashi H.
        Correlation of binding sites for diisopropyl phosphorofluoridate with cholinesterase and neuropathy target esterase in membrane and cytosol preparations from hen.
        NeuroToxicology 22 :203-314, 2001.


      • Kamata R, Saito SY, Suzuki T, Takewaki T, Kofujita H, Ota M, Kobayashi H.
        A comparative study of binding sites for diisopropyl phosphorofluoridate in membrane and cytosol preparations from spinal cord and brain of hens.
        NeuroToxicology 22:191-202, 2001.


      • Shiina T, Morimatsu M, Kitamura H, Ito T, Kidou S, Matsubara K, Matsuda Y, Saito M, Syuto B.
        Genomic organization, chromosomal localization, and promoter analysis of the mouse Mail gene.
        Immunogenetics 53:649-655, 2001.




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      @2000
      • Thapaliya S, Matsuyama H, Takewaki T.
        Bradykinin causes endothelium-independent hyperpolarisation and neuromodulation by prostanoid synthesis in hamster mesenteric artery.
        Eur. J. Pharmacol. 408:313-321, 2000.


      • Unno T, Inaba T, Ohashi H, Takewaki T, Komori S.
        Role of Ca2+ mobilization in muscarinic receptor-mediated membrane depolarization in guinea pig ileal smooth muscle cells.
        Jpn. J. Pharmacol. 84:431-437, 2000


      • Takeuchi T, Negoro T, Yamaji M, Yamazaki Y, Fujita A, Nishio H, Takewaki T, Takatsuji K, Hata F.
        Increase in participation of vasoactive intestinal peptide in relaxation of the distal colon of Wistar rats with age.
        Br. J. Pharmacol. 131:942-948, 2000.


      • Kishi M, Takeuchi T, Katayama H, Yamazaki Y, Nishio H, Hata F, Takewaki T.
        Involvement of cyclic AMP - PKA pathway in VIP-induced, charybdotoxin-sensitive relaxation of longitudinal muscle of the distal colon of Wistar-ST rats.
        Br. J. Pharmacol. 129:140-146, 2000.


      • Ogiso K, Shimizu Y, Watanabe K, Tonosaki K.
        Possible involvement of undissociated acid molecules in the acid response of the chorda tympani nerve of the rat.
        J. Neurophysiol. 83:2776-2779, 2000.


      • Nakayasu C, Kanemura F, Hirano Y, Shimizu Y, Tonosaki K.
        Sensitivity of the olfactory sense declines with the aging in senescence-accelerated mouse (SAM-P1).
        Physiol. Behav. 70:135-139, 2000.


      • Sakurai N, Kanemura F, Watanabe K, Shimizu Y, Tonosaki K.
        Effects of acids on neural activity elicited by other taste stimuli in the rat Chorda tympani.
        Brain Res. 859:369-372, 2000.



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      @1999
      • Thapaliya S, Matsuyama H, Takewaki T.
        ATP released from perivascular nerves hyperpolarizes smooth muscle cells by releasing an endothelium-derived factor in hamster mesenteric arteries.
        J. Physiol. 521:191-199, 1999.


      • Matsuyama H, Thapaliya S, Takewaki T.
        Cyclic GMP-associated apamin-sensitive nitrergic slow inhibitory junction potential in the hamster ileum.
        Br. J. Pharmacol. 128:830-836, 1999



      • Takeuchi T, Kishi M, Hirayama N, Yamaji M, Ishii T, Nishio H, Hata F, Takewaki T.
        Tyrosine kinase involvement in apamin-sensitive inhibitory responses of rat distal colon.
        J. Physiol. 514 :177-188. 1999



      • Shimizu Y, Tonosaki K.
        Low environmental temperature modulates gustatory nerve activity and behavioral responses to NaCl in rats.
        Am. J. Physiol. 277:R368-R373, 1999.



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      @1998
      • Takeuchi T, Niioka S, Kishi M, Ishii T, Nishio H, Hata F, Takewaki T, Takatsuji K.
        Nonadrenergic, noncholinergic relaxation mediated by nitric oxide with concomitant change in Ca2+ level in rectal circular muscle of rats.
        Eur. J. Pharmacol. 353:67-74, 1998


      • Shimizu Y, Satoh S, Yano H, Minokoshi Y, Cushman SW, Shimazu T.
        Effects of noradrenaline on the cell-surface glucose transporters in cultured brown adipocytes: novel mechanism for selective activation of GLUT1 glucose transporter.
        Biochem. J. 330:397-403, 1998


      • Ota M, Shimizu Y, Tonosaki K, Ariyoshi Y.
        Role of hydrophobic amino acids in gurmarin, a sweetness-suppressing polypeptide.
        Biopolymers 45:231-238, 1998


      • Ota M, Shimizu Y, Tonosaki K, Ariyoshi Y.
        Synthesis, characterization, and sweetness-suppressing activities of gurmarin analogues missing one disulfide bond.
        Biopolymers 46: 65-73, 1998



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      @1997
      • Niioka S, Takeuchi T, Kishi M, Ishii T, Nishio H, Takewaki T, Hata F.
        Nonadrenergic, noncholinergic relaxation in longitudinal muscle of rat jejunum.
        Jpn. J. Pharmacol. 73:155-161, 1997
        .


      • Shimizu Y, Tanishita T, Minokoshi Y, Shimazu T.
        Activation of mitogen-activated protein kinase by norepinephrine in brown adipocytes from rats.
        Endocrinology 138:248-253, 1997


      • Tanishita T, Shimizu Y, Minokoshi Y, Shimazu T.
        The
        ƒÀ3-adrenergic agonist BRL37344 increases glucose transport into L6 myocytes through a mechanism different from that of insulin.
        J. Biochem. 122:90-95, 1997

        3:119-124, 1997



      @

      @1996
      • Kishi M, Takeuchi T, Suthamnatpong N, Ishii T, Nishio H, Hata F, Takewaki T.
        VIP- and PACAP-mediated nonadrenergic, noncholinergic inhibition in longitudinal muscle of rat distal colon: involvement of activation of charybdotoxin- and apamin-sensitive K+ channels.
        Br. J. Pharmacol. 119:623-630, 1996


      • Shimizu Y, Kielar D, Minokoshi Y, Shimazu T.
        Noradrenaline increases glucose transport into brown adipocytes in culture by a mechanism different from that of insulin.
        Biochem. J. 314:485-490, 1996


      • Nikami H, Shimizu Y, Sumida M, Minokoshi Y, Yoshida T, Saito M, Shimazu T.
        Expression of
        ƒÀ3-adrenoceptor and stimulation of glucose transport by ƒÀ3-agonist in brown adipocyte primary culture.
        J. Biochem. 119:120-125, 1996


      • Fukuzumi M, Shinomiya H, Shimizu Y, Ohishi K, Utsumi S.
        Endotoxin-induced enhancement of glucose influx into murine macrophages via GLUT1.
        Infect. Immun. 108:108-112, 1996


      • Minokoshi Y, Shimizu Y, Shimazu T.
        Hypothalamic and sympathetic nervous regulation of glucose uptake in certain peripheral tissues.
        Liver Innervation (Shimazu, T. Ed.) John Libbey & Company Ltd., London, 227-236, 1996




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        @1995
        • Tsukazaki K, Nikami H, Shimizu Y, Kawada T, Yoshida T, Saito M.
          Chronic administration of
          ƒÀ-adrenergic agonists can mimic the stimulative effect of cold exposure on protein synthesis in rat brown adipose tissue.
          J. Biochem. 117:96-100, 1995


        • Shimazu T, Shimizu Y, Minokoshi Y.
          Roles of the hypothalamus and sympathetic nerves in the regulation of thermogenesis and glucose transport in brown adipose tissue.
          Body Temperature and Metabolism (Nagasaka T. And Milton, A.S. Eds.) IPEC., Tokyo, pp179-182, 1995



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        @1994
        • Ohashi H, Takewaki T, Unno T, Komori S.
          Mechanical and current responses to neurotensin in the smooth muscle of guinea-pig intestine.
          J. Auton. Pharmacol. 14:239-251, 1994


        • Shimizu Y, Kielar D, Masuno H, Minokoshi Y, Shimazu T.
          Dexamethasone induces GLUT4 glucose transporter, and responses of glucose transport to norepinephrine and insulin in primary culture of brown adipocytes.
          J. Biochem. 115:1069-1074, 1994


        • Shimizu Y, Shimazu T.
          Effects of wortmannin on increased glucose transport by insulin and norepinephrine in primary culture of brown adipocytes.
          Biochem. Biophys. Res. Commun. 202:660-665, 1994


        • Machado UF, Shimizu Y, Saito M.
          Reduced content and preserved translocation of glucose transporter (GLUT4) in white adipose tissue of obese mice.
          Physiol. Behav. 55:621-625, 1994


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        @1993
        • Shimizu, Y., Nikami, H., Tsukazaki, K., Machado, U. F., Yano, H., Seino, Y., Saito, M.
          Increased expression of glucose transporter GLUT-4 in brown adipose tissue of fasted rats after cold exposure.
          Am. J. Physiol. 264: E890-E895, 1993.


        • Machado, U. F., Shimizu, Y., Saito, M.
          Decreased glucose transporter (GLUT4) content in insulin-sensitive tissues of obese aurothioglucose- and monosodium glutamate-treated mice.
          Horm. Metab. Res. 25 : 462-465, 1993.



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        @1992
        • Nikami, H., Shimizu, Y., Endoh, D., Yano, H., Saito, M.
          Cold exposure increases glucose utilization and glucose transporter expression in brown adipose tissue.
          Biochem. Biophys. Res. Commun. 185: 1078-1082, 1992.



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        @1991
        • Shimizu, Y., Saito, M.
          Activation of brown adipose tissue thermogenesis in recovery from anesthetic hypothermia in rats.
          Am. J. Physiol. 261: R301-R304, 1991.


        • Shimizu, Y., Nikami H., Saito, M.
          Sympathetic activation of glucose utilization in brown adipose tissue in rats.
          J. Biochem. 110: 688-692, 1991.


        • Saito, M., Akiyoshi M., Shimizu, Y.
          Possible role of the sympathetic nervous system in responses to interleukin-1.
          Brain Res. Bull. 27: 305-308, 1991.


        • Shimizu, Y., Suzuki, M.
          The relationship between red cell aging and enzyme activities in experimental animals.
          Comp. Biochem. Physiol. 99B: 313-316, 1991.


        • Shimizu, Y., Kawarada, S., Suzuki, M., Tanaka, T.
          Interstrain differences in red cell enzyme activities in mice and rats.
          Comp. Biochem. Physiol. 100B: 687-690, 1991.


        • Saito, M., Shimizu, Y., Minokoshi, Y., Shimazu, T.
          Hypothalamic and sympathetic nerve control of brown adipose tissue metabolism and thermogenesis.
          In "Progress in Obesity Research 1990 " Oomura, Y. et al. eds., John Libbey & Company Ltd., London, pp. 131-134, 1991.

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        @1990
        • Akiyoshi, M., Shimizu, Y., Saito, M.
          Interleukin-1 increases norepinephrine turnover in the spleen and lung in rats.
          Biochem. Biophys. Res. Commun. 173: 1266-1270, 1990.