＜原著論文＞

1. Nordihydroguaiaretic acid (NDGA) blocks the differentiation of C2C12 myoblast cells, H. Ito, H. Ueda, I. Iwamoto, Y. Inaguma, T. Takizawa, T. Asano and K. Kato, J. Cell. Physiol., 202, 874-879 (2005)

2. Gi2 Signaling Enhances Proliferation of Neural Progenitor Cells in the Developing Brain, H. Shinohara, J. Udagawa, R. Morishita, H. Ueda, H. Otani, R. Semba, K. Kato, and T. Asano, J. Biol. Chem (2004)

3. G/11 Signaling Induces Apoptosis through Two Pathways Involving Reduction of Akt Phosphorylation and Activation of RhoA in HeLa Cells, H. Ueda, R. Morishita, S. Narumiya, K. Kato, and T. Asano, Exp. Cell Res., 298, 207-217 (2004)

4. Riluzole enhances expression of brain-derived neurotrophic factor with consequent proliferation of granule precursor cells in the rat hippocampus, R. Katoh-Semba, T. Asano, H. Ueda, R. Morishita, I. K. Takeuchi, Y. Inaguma and K. Kato, FASEB J., 16, 1328-1330 (2002) (Online# 10.1096/fj.02-0143fje).

5.  Goniodomin A, an antifungal polyether macrolide, exhibits antiangiogenic activities via inhibition of actin reorganization in endothelial cells, M. Abe, D. Inoue, K. Matsunaga, Y. Ohizumi, H. Ueda, T. Asano, M. Murakami and Y. Sato, J. Cell. Physiol., 190, 109-116 (2002).

6. Beef tallow, but not perilla or corn oil, promotion of rat prostate and intestinal carcinogenesis by 3,2'-dimethyl-4-aminobiphenyl, T. Mori, K. Imaida, S. Tamano, M. Sano, S. Takahashi, M. Asamoto, M. Takeshita, H. Ueda and T. Shirai, Jpn. J. Cancer Res., 92, 1026-1033 (2001).

7. Selective localization of G protein γ5 subunit in the subventricular zone of the lateral ventricle and rostral migratory stream of the adult rat brain, T. Asano, H. Shinohara, R. Morishita, H. Ueda, N. Kawamura, R. Katoh-Semba, M. Kishikawa and K. Kato, J. Neurochem., 79, 1129-1135 (2001).

8. Gα11 induces caspase-mediated proteolytic activation of Rho-associated kinase, ROCK-I, in HeLa Cells, H. Ueda, R. Morishita, H. Itoh, S. Narumiya, K. Mikoshiba, K. Kato and T. Asano, J. Biol. Chem., 276, 42527-42533 (2001).

9.  Regulation of Rac and Cdc42 pathways by Gi during lysophosphatidic acid-induced cell spreading, H. Ueda, R. Morishita, J. Yamauchi, H. Itoh, K. Kato and T. Asano, J. Biol. Chem., 276, 6846-6852 (2001).

10.  G protein βγ subunits induce stress fiber formation and focal adhesion assembly in a Rho-dependent manner in HeLa cells, H. Ueda, H. Itoh, J. Yamauchi, R. Morishita, Y. Kaziro, K. Kato and T. Asano, J. Biol. Chem., 275, 2098-2102 (2000).

11. A new analytical method for the detection of anti-tumor promoters using flow cytometry, Y. Zaizen, H. Tokuda, H. Ueda, H. Nishino, C. Ishikawa and M. Takeshita, Anticancer Res., 19, 5207-5209 (1999).

12. High expression of the γ5 isoform of G protein in neuroepithelial cells and its replacement of the g2 isoform during neuronal differentiation in the rat brain, R. Morishita, H. Shinohara, H. Ueda, K. Kato and T. Asano, J. Neurochem., 73, 2369-2374 (1999).

13.  Selective association of G protein β4 with γ5 and γ12 subunits in bovine tissues, T. Asano, R. Morishita, H. Ueda and K. Kato, J. Biol. Chem., 274, 21425-21429 (1999).

14. Phosphorylation of F-actin-associating G protein γ12 subunit enhances fibroblast motility, H. Ueda, J. Yamauchi, H. Itoh, R. Morishita, Y. Kaziro, K. Kato and T. Asano, J. Biol. Chem., 274, 12124-12128 (1999).

15. G protein γ subunits coimmunoprecipitated with antibodies against α subunits: Identification of major isoforms in cultured cells by silver stain and immunoblotting with conventional transfer procedure, H. Ueda, R. Morishita, R. Katoh-Semba, K. Kato and T. Asano, J. Biochem., 124, 1033-1037 (1998).

16. Specific isoprenyl group linked to transducin γ-subunit is a determinant of its unique signaling properties among G-proteins, T. Matsuda, Y. Hashimoto, H. Ueda, T. Asano, Y. Matsuura, T. Doi, T. Takao, Y. Shimonishi and Y. Fukada, Biochemistry, 37, 9843-9850 (1998).

17.  Identification of two forms of the γ subunit of G protein, γ10 and γ11, in bovine lung and their tissue distribution in the rat, R. Morishita, H. Ueda, K. Kato and T. Asano, FEBS Lett., 428, 85-88 (1998).

18. GTP-binding protein γ12 subunit phosphorylation by protein kinase C: Identification of the phosphorylation site and factors involved in cultured cells and rat tissues in vivo, T. Asano, R. Morishita, H. Ueda, M. Asano and K. Kato, Eur. J. Biochem., 251, 314-319 (1998).

19. Association of the γ12 subunit of G proteins with actin filaments, H. Ueda, S. Saga, H. Shinohara, R. Morishita, K. Kato and T. Asano, J. Cell Sci., 110, 1503-1511 (1997).

20. Lack of promotion of colon carcinogenesis by high-oleic safflower oil, M. Takeshita, H. Ueda, K. Shirabe, Y. Higuchi and S. Yoshida, Cancer, 79, 1487-1493 (1997).

21. Two different activities of phospholipase A₂ in porcine aortic cytosol, L. Y. Hao, H. Ueda, T. Yubisui and M. Takeshita, Life Sci., 59, 1443-1454 (1996).

22. Lysophosphoinositide-specific phospholipase C in rat brain synaptic plasma membranes, T. Tsutsumi, T. Kobayashi, H. Ueda, E. Yamauchi, S. Watanabe and H. Okuyama, Neurochem. Res., 19, 399-406 (1994).

23. A possible pathway of phosphoinositide metabolism through EDTA-insensitive phospholipase A₁ followed by lysophosphoinositide-specific phopholipase C in rat brain, H. Ueda, T. Kobayashi,  M. Kishimoto, T. Tsutsumi and H. Okuyama, J. Neurochem., 61, 1874-1881 (1993).

24. The presence of Ca²⁺-independent phospholipase A₁ highly specific for phosphatidylinositol in bovine brain, H. Ueda, T. Kobayashi, M. Kishimoto, T. Tsutsumi, S. Watanabe and H. Okuyama, Biochem. Biophys. Res. Commun., 95, 1277-1279 (1993).

25. EDTA-insensitive deacylation of phosphatidylinositol in porcine platelet membranes, H. Ueda, T. Kobayashi, M. Kishimoto, T. Tsutsumi, S. Watanabe and H. Okuyama,  Life Sci., 53, 629-634 (1993).

＜総説＞

1. ホスホリパーゼ，上田浩，奥山治美，The Lipid，2，55-62 (1991).

2. 三量体Ｇ蛋白質によるRhoファミリー低分子量Ｇ蛋白質を介する細胞骨格制御，上田浩，浅野富子，生化学，73，568-571 (2001).