＜論文＞

●原著●
(1) S. Minatoguchi, H. Ito, K. Ishimura, H. Watanabe, Y. Imai, M. Koshiji, K. Asano, S. Hirakawa, H. Fujiwara
Modulation of noradrenaline release through presynaptic α2-adrenoceptors in congestive heart failure
Am Heart J 1995, 130(3):516-521

(2) R. Yokota, H. Fujiwara, M. Miyamae, M. Tanaka, K. Yamasaki, S. Itoh, K. Koga, Y. Yabuuchi, S. Sasayama
Transient adenosine infusion before ischemia and reperfusion protects against metabolic damage in pig hearts
Am. J. Physiol 1995, 268(Heart Circ. Physiol. 37):H1149-H1157

(3) S. Minatoguchi, H. Ito, M. Kakami, K. Asano, M. Koshiji, Y. Uno, H. Yokoyama, H. Fujiwara
Behavior of plasma free and conjugated noradrenaline -a comparison of patients with mild heart failure and patients with chronic hemodialysis
Biogenic Amines 1995, 11(4):355-361

(4) S. Minatoguchi, H. Ito, K. Ishimura, T. Suzuki, N. Tonai, M. Mori, S. Hirakawa, H. Fujiwara
Plasma adrenaline modulates a1-adrenoceptor mediated pressor responses and the baroreflex control in patients with borderline hypertension
Blood Pressure 1995, 4:105-112

(5) H. Fujiwara, K. Nishigaki
Small coronary artery disease in cardiomyopathy: hypertrophic cardiomyopathy resembling dilated cardiomyopathy
Coronary Artery Disease 1995, 6:213-219

(6) G. Takemura, Y. Takatsu, K. Ono, T. Miyatake, M. Ono, T. Izumi, H. Fujiwara
Usefulness of electron microscopy for the diagnosis of cardiac sarcoidosis: a case report
Heart & Vessels 1995, 10:275-278

(7) G. Takemura, H. Fujiwara, Y. Takatsu, T. Fujiwara, K. Nakao
Ventricular Expression of atrial and brain natriuretic peptides in patients with myocarditis
Int J Cardiol 1995, 52:213-222

(8) S. Hirakawa, T. Suzuki, K. Gotoh, H. Ito, T. Tanaka, Y. Ohsumi, Y. Yagi, Y. Terasima, H. Fujiwara, K. Nagasima, T. Sawa, T. Tsukamoto
Human pulmonary vascular and venous compliances are reduced before and during left-sided heart failure
J Appl Physiol 1995, 78(1):323-333

(9) A. Kano, K. Kambara, F. Ando, K. Nishigaki, H. Fujiwara
Effects of ventilation and pleural effusion on measurements of airway thermal volume and blood flow in dog lungs
J Appl Physiol 1995, 79(4):1320-1329

(10) H. Takatsu, H. Fujiwara
Sympathetic tone assessed by washout of iodine 125-labeled metaiodobenzylguanidine from the murine left ventricle -influence of immobilization stress and inhibition of the renin-angiotensin system
J Nucl Cardiol 1995, 2:507-512

(11) H. Takatsu, Y. Uno, H. Fujiwara
Modulation of Left Ventricular Iodine-125-MIBG Accumulation in Cardiomyopathic Syrian Hamsters Using the Renin-Angiotensin System
J Nucl Med 1995, 36:1055-1061

(12) H. Suzuki, M. Tanaka, H. Yoshifusa, Y. Nakamura, Y. Shibata
Antithrombotic effect of ticlopidine on occlusive thrombi of small coronary arteries in(NZWxBXSB)F1 male mice with myocardial infarction and systemic lupus erythematosus
Journal of Cardiovascular pharmacology 1995, 25:9-13

(13) S.Minatoguchi, H. Ito, T. Suzuki, M. Koshiji, M. Kakami, Y. Uno, K. Asano, K. Yamashita, S. Hirakawa, H. Fujiwara
Conversion of plasma noradrenaline from conjugated from into free from in the heart and its physiological significance in patients with cardiac disease -a comparison between at rest and during exercise-
Biogenic Amines 1995, 11(5):417-432

(14) 富田政明、苅谷達也、白木　尚、荒川迪生、藤原久義
肥大型閉塞性心筋症における左室流出路圧較差出現の機序　ー心房細動例における検討ー
呼吸と循環　1995, 43:385-390

(15) 野村万寿美、後藤紘司、八木安生、飯田真美、出口富美子、長島賢司、澤　祥幸、安田憲生、藤原久義
体位性誘発ラ音(PIC)の出現"時相"に関する検討
Ther Res 1995, 16:79-82

(16) 浅野喜代治、伊藤裕康、後藤紘司、藤原久義、森　矩尉、岩砂和雄、加藤俊彦、渡辺郁雄、杉下総吉、堀江和子、上村博之、大角幸男、大平敏樹、小田　寛、茜部　寛、今井直幸、皆川太郎、森田則彦、佐橋照親、西尾　斉、土屋邦彦、篠田徳郎
抗不整脈薬Ic剤ピルジカイニドの心室性期外収縮に対する効果　ーPQ間隔延長と効果の関連ー
Ther Res 1995, 16:174-177

(17) 井奈波良一、岩田弘敏、越路正敏、藤原久義、杉浦春雄
漢方外来受診者の東洋医学、温泉医学に関する意識調査
日本医事新報　1995, 10.7 3728:46-50

(18) 木下道広、松本圭司、市川桂二、鷹津良樹、尾野　亘、竹村元三、藤原久義
Guillain-Barre症候群を合併した急性劇型心筋炎の一例
日本内科学会雑誌　1995, 84:284-286

(19) 佐井篤儀、小木曽仁、藤沢　攻、加川憲作、富田政明、藤原久義
MR画像からの局所的心機能の定量評価
Medical Imaging and Information Sciences 1995, 12:74-81

(20) 平岡実子、浅野喜代治、湊口信也、今井洋子、越路正敏、宇野嘉弘、各務雅夫、横山仁美、藤原久義、伊藤裕康
腎機能障害を有する左心疾患患者に対するCa++拮抗剤(Barnidipine)の血行動態・腎機能への急性効果
臨床薬理　1995, 26:255-256

●著書・総説など●
(1) X. Jiang, K. Kambara, A. Kano, K. Nishigaki, N. Gotoh, H. Fujiwara
Efect of high-dose beraprost sodium on ischemia-reperfusion pulmonary capillary injury in rabbit
Pulmonary Circulation Research 1995, in press

(2) 井形昭弘、大澤仲弘、柏木征三郎、藤原久義
長寿科学と漢方　ー分化から総合への漢方的アプローチー
漢方医学　1995, 19(1):1-

(3) 藤原久義
成人期川崎病の諸問題
岐阜県心臓病児物者の会（特集号） 1995, 179:5ｰ6

(4) 西垣和彦、藤原久義
Up Date循環調節ペプチド研究の新展開　ーナトリウム利尿ペプチドファミリーと心肥大ー
現代医療　1995, 27:111-115

(5) 藤原久義
漢方外来診療
治療　1995, 77(7):118ｰ119

(6) 神原健治郎、加納亜紀、藤原久義
ARDSの臨床　ー肺水分量測定と輸液療法ー
臨床医　1995, 21(7):46-49

(7) 野田俊之、藤原久義
冠動脈疾患　ー心不全への対策ー
臨床医　1995, 21(8):74-77

<国際学会発表>

XVIIth International Symposium on Cerebral Blood Flow and Metabolism,BRAIN95 (Cologe,Germany) 1995, 7.2-6
(1) M. Iida, H. Iida, T. Ishiyama, Y. Watanabe, S. Dohi
Acte effects of cigarette smoking on pial vessels

The 11th ASIAN-PACIFIC CONGRESS OF CARDIOLOGY (Bali,Indonesia) 1995, 9.19
(2) K. Asano, H. Ito, S. Minatoguchi, M. Koshiji, Y. Uno, M. Kakami, H. Yokoyama, J. Hiraoka, H. Fujiwara
Plasma conjugated noradrenaline increases during congestive heart failure - role of renal excretion-

12th Meeting of Japanese Section of International Society for Heart Research (Osaka, Japan) 1995, 12.1
(3) S. Minatoguchi, T. Kariya, Y. Uno, H. Fujiwara, M. Koshiji, T. Fujiwara
Preconditioning elevates tissuenoradrenalinee levels in inner layer of myocardium in the area at risk

(4) T. Kariya, S. Minatoguchi, T. Ohno, Y. Uno, M. Arai, M. Koshiji, T. Fujiwara
Selective α1-antagonist bunazosin can dose-dependently block infarct size limiting effect of ischemic preconditioning in rabbits

The 68th American Heart Association Scientific Sessions (Anaheim, USA) 1995, 11.13-16
(5) K. Nishigaki, S. Minatoguchi, S. Watanabe, H. Fujiwara
Remarkable expression of brain natriuretic peptide is a special feature of hypertrophic obstructive cardiomyopathy

The Fifth Antwerp-La Jolla-Kyoto Research Conference on Cardiac Function (Kyoto, Japan) 1995, 12.13-15
(6) K. Nishigakai, M. Tomita, K. Kagawa, T. Noda, S. Minatoguchi, S. Watanabe, N. Morita, H. Fujiwara
Marked expression of plasma brain natriuretic peptide in hypertrophic obstructive cardiomyopathy

＜受賞項目＞

湊口信也
(1) 第9回中日合同循環器会議発表奨励賞（西安、中国）1997, 9-10
Effect of captopril and losartan on noradrenaline release and vascular reactivity to noradrenaline in the pithed rats -role of bradykinin B2 receptor- mediated production of nitric oxide

野田俊之
(1) 車両競技公益資金記念財団よりの研究事業助成　1995-1998
心臓病の基礎的研究事業「特発性心筋症に関する研究」
閉塞性肥大型心筋症の成因に対するBNPの関与

竹村元三
(1) 第12回冠動脈疾患・心不全研究会優秀研究賞　1997, 10.18
心筋梗塞のいわゆるapoptotic myocytesはoncotic myocytes with DNA fragmentationの可能性がある　ー電顕レベルでのTUNEL法による検討ー

西垣和彦
(1) 日本循環器学会 第14回 YOUNG INVESTIGATOR'S AWARD (YIA)優秀賞（第61回日本循環器学会学術集会、東京国際フォーラム）1997, 4.1
Plasma Fas Ligand, an Inducer of Apoptosis, and Plasma Soluble Fas, an Inhibitor of Apoptosis, in Patients with Chronic Congestive Heart Failure

大野道也
(1) 外山基金による国際交流助成（名古屋）1997, 10.18
So-called Apoptotic Myocytes in the Infarct Area May Be Oncotic Myocytes with DNA
Fragmentation in Rabbit Hearts-Analysis by Electron Microscopic TUNEL

早川幸博
(1) 外山基金による国際交流助成（名古屋）1997, 10.18
Overexpression of Bax Protein and Bax mRNA, an Inducer of Apoptosis, in Human
Arteriosclerosis