Research of Assistant Professor Ishiguro¶

Investigating the physical properties of oligomeric proteins using high-pressure native gel electrophoresis and using high-pressure native gel electrophoresis, FT-IR spectroscopy, and light scattering methods to study the effects of surfactants on lipid bilayers.

../../_images/ishiguro1.jpg — **Investigating the physical properties of oligomeric proteins using high-pressure native gel electrophoresis**¶

Unveiling the secrets of proteins using high pressure!¶

Experiments to unravel the mysteries of proteins¶

In this research, we are using a powerful tool called high pressure to investigate in detail how proteins combine to function.

We employ a method called high-pressure native gel electrophoresis. This method allows us to observe proteins arranged by size, similar to arranging sushi. By applying high pressure, we can change the way proteins assemble and examine this process in detail.

What we can learn from this experiment¶

From this experiment, we can learn in detail about the conditions under which proteins combine, how they combine, and how strong these combinations are, through their volume.

What you can gain from this research¶

You can learn the following:

Chemical thermodynamics: The study of how energy changes during a process.
Kinetics: The study of how fast chemical reactions occur.
Experimental techniques: You can acquire various experimental techniques, such as high-pressure experiments.
Data analysis: Learn how to analyze experimental data using custom software and extract meaning from it.

Summary¶

In this research, we are using the powerful tool of high pressure to unravel the secrets of proteins. Through this research, you may be able to gain a deep thermodynamic understanding of protein function and the causes of disease, and contribute to the development of new drugs in the future.